Figure 15-49. Seven subfamilies of receptor tyrosine kinases.

Figure 15-49Seven subfamilies of receptor tyrosine kinases

Only one or two members of each subfamily are indicated. Note that the tyrosine kinase domain is interrupted by a “kinase insert region” in some of the subfamilies. The functional roles of most of the cysteine-rich, immunoglobulin-like, and fibronectin-type III-like domains are not known. Some of the ligands and responses for the receptors shown are listed in Table 15-4.

From: Signaling through Enzyme-Linked Cell-Surface Receptors

Cover of Molecular Biology of the Cell
Molecular Biology of the Cell. 4th edition.
Alberts B, Johnson A, Lewis J, et al.
New York: Garland Science; 2002.
Copyright © 2002, Bruce Alberts, Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts, and Peter Walter; Copyright © 1983, 1989, 1994, Bruce Alberts, Dennis Bray, Julian Lewis, Martin Raff, Keith Roberts, and James D. Watson .

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