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Alberts B, Johnson A, Lewis J, et al. Molecular Biology of the Cell. 4th edition. New York: Garland Science; 2002.

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Molecular Biology of the Cell. 4th edition.

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Figure 19-39. The linkage between a GAG chain and its core protein in a proteoglycan molecule.

Figure 19-39The linkage between a GAG chain and its core protein in a proteoglycan molecule

A specific link tetrasaccharide is first assembled on a serine side chain. In most cases, it is unclear how the particular serine is selected, but it seems that a specific local conformation of the polypeptide chain, rather than a specific linear sequence of amino acids, is recognized. The rest of the GAG chain, consisting mainly of a repeating disaccharide unit, is then synthesized, with one sugar being added at a time. In chondroitin sulfate, the disaccharide is composed of D-glucuronic acid and N-acetyl-D-galactosamine; in heparan sulfate, it is D-glucosamine (or L-iduronic acid) and N-acetyl-D-glucosamine; in keratan sulfate, it is D-galactose and N-acetyl-D-glucosamine.

From: The Extracellular Matrix of Animals

Copyright © 2002, Bruce Alberts, Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts, and Peter Walter; Copyright © 1983, 1989, 1994, Bruce Alberts, Dennis Bray, Julian Lewis, Martin Raff, Keith Roberts, and James D. Watson .

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