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Figure 16-43. Loss of filamin causes abnormal cell motility.

Figure 16-43Loss of filamin causes abnormal cell motility

(A) A group of melanoma cells that have an abnormally low level of filamin. These cells are not able to make normal lamellipodia and instead are covered with membrane “blebs.” As a result, they crawl poorly and tend not to metastasize. (B) The same melanoma cells in which filamin expression has been artificially restored. The cells now make normal lamellipodia and are highly metastatic. This example is one of many demonstrating the profound effect that the presence or absence of a single structural protein can have on cell morphology and motility. (From C. Cunningham et al., J. Cell Biol. 136:845–857, 1997. © The Rockefeller University Press.)

From: How Cells Regulate Their Cytoskeletal Filaments

Cover of Molecular Biology of the Cell
Molecular Biology of the Cell. 4th edition.
Alberts B, Johnson A, Lewis J, et al.
New York: Garland Science; 2002.
Copyright © 2002, Bruce Alberts, Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts, and Peter Walter; Copyright © 1983, 1989, 1994, Bruce Alberts, Dennis Bray, Julian Lewis, Martin Raff, Keith Roberts, and James D. Watson .

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