Figure 156.2. Patterns of abnormality.

Figure 156.2

Patterns of abnormality. (A) Marrow hypoplasia. There is a reduced number of reticulocytes. The percentage of young reticulocytes with enough RNA to cause polychromatophilia is normal. (B) Chronic hemolytic anemia. The number of reticulocytes is increased. Also, as a "shift" response to anemia the reticulocytes are released earlier from the bone marrow. Earlier release means higher RNA content on release, longer persistence of RNA, and a higher proportion of visibly polychromatophilic cells. (C) Acute marrow response. The reticulocyte percentage is higher, but their distribution of maturation is similar to normal, so relatively few are polychromatophilic. The pattern is typical of marrow recovery from nutritional deficiency, marrow suppression, or blood loss. (D) Marrow infiltration. There is a normal number of reticulocytes, but an increased percentage of prematurely released polychromatophilic cells.

From: Chapter 156, Reticulocytes

Cover of Clinical Methods
Clinical Methods: The History, Physical, and Laboratory Examinations. 3rd edition.
Walker HK, Hall WD, Hurst JW, editors.
Boston: Butterworths; 1990.
Copyright © 1990, Butterworth Publishers, a division of Reed Publishing.

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