Table 150.1Causes of Splenomegaly

Vascular congestion
 Cirrhosis
 Splenic vein thrombosis
 Portal vein thrombosis
Reticuloendothelial hyperplasia
 Acute infections (e.g., typhoid fever, cytomegalovirus, Epstein-Barr virus infection)
 Subacute or chronic infections (e.g., bacterial endocarditis, brucellosis, tuberculosis, histoplasmosis, malaria)
 Collagen-vascular diseases and abnormal immune responses (e.g., systemic lupus erythematosus, serum sickness, sarcoidosis)
Work hypertrophy
 Hemolytic anemias (e.g., spherocytosis)
Infiltrative or replacement processes
 Nonmalignant hematologic disorders (e.g., polycythemia vera, myelofibrosis)
 Leukemias
 Lymphomas
 Metastatic solid tumors
 Storage diseases (e.g., Gaucher's disease)
 Amyloidosis
 Benign tumor and cysts
 Abscess
 Subcapsular hemorrhage

From: Chapter 150, Spleen

Cover of Clinical Methods
Clinical Methods: The History, Physical, and Laboratory Examinations. 3rd edition.
Walker HK, Hall WD, Hurst JW, editors.
Boston: Butterworths; 1990.
Copyright © 1990, Butterworth Publishers, a division of Reed Publishing.

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