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FIGURE 19.12. Pressure ejection of 70 mM KCl (black arrowheads) causes release of L-glutamate in the striatum of a C57BL/6 mouse.

FIGURE 19.12

Pressure ejection of 70 mM KCl (black arrowheads) causes release of L-glutamate in the striatum of a C57BL/6 mouse. Non-Faradaic current decreases the signal-to-noise ratio making it difficult to distinguish between current fluctuations and low L-glutamate responses. The noise occurs on both the L-glutamate oxidase coated sites and the sentinel recordings sites. When the raw current from the sentinel recording site is subtracted from the raw current on the L-glutamate oxidase coated sites, the noise is removed creating a higher signal-to-noise ratio for L-glutamate measurements.

From: Chapter 19, Second-by-Second Measures of L-Glutamate and Other Neurotransmitters Using Enzyme-Based Microelectrode Arrays

Cover of Electrochemical Methods for Neuroscience
Electrochemical Methods for Neuroscience.
Michael AC, Borland LM, editors.
Boca Raton (FL): CRC Press; 2007.
Copyright © 2007, Taylor & Francis Group, LLC.

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