Copyright © 2005, National Academy of Sciences.
NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.
Bookshelf ID: NBK25462PMID: 20669460
Catalyzing Inquiry at the Interface of Computing and Biology
Edited by John C Wooley and Herbert S Lin. National Research Council (US) Committee on Frontiers at the Interface of Computing and Biology.
Washington (DC): National Academies Press (US); 2005.
ISBN-10: 0-309-09612-X
Excerpt
This report by the Committee on Frontiers at the Interface of Computing and Biology seeks to establish the intellectual legitimacy of a fundamentally cross-disciplinary collaboration between biologists and computer scientists. That is, while some universities are increasingly favorable to research at the intersection, life science researchers at other universities are strongly impeded in their efforts to collaborate. This report addresses these impediments and describes some strategies for overcoming them.
Contents
- The National Academies
- Committee on Frontiers at the Interface of Computing and Biology
- Computer Science and Telecommunications Board
- Preface
- Acknowledgment of Reviewers
- Executive Summary
- 1. Introduction
- 2. 21st Century Biology
- 3. On the Nature of Biological Data
- 4. Computational Tools
- 5. Computational Modeling and Simulation as Enablers for Biological Discovery
- 6. A Computational and Engineering View of Biology
- 7. Cyberinfrastructure and Data Acquisition
- 8. Biological Inspiration for Computing
- 9. Illustrative Problem Domains at the Interface of Computing and Biology
- 9.1 WHY PROBLEM-FOCUSED RESEARCH?
- 9.2 CELLULAR AND ORGANISMAL MODELING
- 9.3 A SYNTHETIC CELL WITH PHYSICAL FORM
- 9.4 NEURAL INFORMATION PROCESSING AND NEURAL PROSTHETICS
- 9.5 EVOLUTIONARY BIOLOGY
- 9.6 COMPUTATIONAL ECOLOGY
- 9.7 GENOME-ENABLED INDIVIDUALIZED MEDICINE
- 9.8 A DIGITAL HUMAN ON WHICH A SURGEON CAN OPERATE VIRTUALLY
- 9.9 COMPUTATIONAL THEORIES OF SELF-ASSEMBLY AND SELF-MODIFICATION
- 9.10 A THEORY OF BIOLOGICAL INFORMATION AND COMPLEXITY
- 10. Culture and Research Infrastructure
- 11. Conclusions and Recommendations
- Appendixes
- What Is CSTB?
Support for this project was provided by the Defense Advanced Research Projects Agency under Contract No. MDA972-00-1-0005, the National Science Foundation under Contract No. DBI-0094528, the Department of Health and Human Services/National Institutes of Health (including the National Institute of General Medical Sciences and the National Center for Research Resources) under Contract No. N01-OD-4-2139, the Department of Energy under Contract No. DE-FG02-02ER63336, the Department of Energy’s Office of Science (BER) under Interagency Agreement No. DE-FG02-04ER63934, and National Research Council funds. Any opinions, findings, conclusions, or recommendations expressed in this publication are those of the author(s) and do not necessarily reflect the views of the organizations or agencies that provided support for the project.
NOTICE: The project that is the subject of this report was approved by the Governing Board of the National Research Council, whose members are drawn from the councils of the National Academy of Sciences, the National Academy of Engineering, and the Institute of Medicine. The members of the committee responsible for the report were chosen for their special competences and with regard for appropriate balance.
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