Table 1The principal pathogenic Helicobacter spp., their hosts, and the diseases causeda

Helicobacter sp.Phylogenetic relatednessbNatural host(s)Experimental host(s)Tissue site(s)Disease(s)
H. pyloriHumans, rhesus monkeys, catscMice, piglets, monkeys, cats, gerbils, guinea pigsStomachGastritis ± ulcer
H. acinonychis97.4%CheetahsMiceStomachGastritis
H. felis95.5%Cats, dogsMice, dogs, ratsStomachGastritis
H. heilmannii95%dSwine, cats, dogs, ferrets,c monkeys, humanscMiceStomachGastritis ± ulcer
H. mustelae93.9%FerretsFerretsStomachGastritis ± ulcer
H. pullorum94.9%Chickens, humansceIntestine (liver)Hepatitis
H. canis93.9%Dogs, catseIntestine (liver)fGastroenteritis, hepatitis
H. bilis93.4%Mice, ratsMiceIntestine (liver)fHepatitis
H. hepaticus93.4%MiceMiceIntestine (liver)fHepatitis, hepatocarcinoma
"H. rappini"93.1%Sheep, dogs,c mice,c humanscGuinea pigsIntestine (stomach)fAbortion, hepatic necrosis
H. fennelliae93.1%HumansMacaque monkeysIntestineProctitis, colitis
H. cinaedi92.8%Humans, hamstersMacaque monkeysIntestine (blood)fProctitis, colitis
a

See also reference 69.

b

Based on 16S rRNA sequence comparisons; expressed as % similarity with H. pylori 16srRNA gene (reference 94).

c

Less frequently found in these animals.

d

Average of similarity values for H. heilmannii-like bacteria isolated from different animal hosts.

e

Experimental infection model not described.

f

Secondary sites of infection.

From: Chapter 45, In Vivo Modeling of Helicobacter-associated Gastrointestinal Diseases

Cover of Helicobacter pylori
Helicobacter pylori: Physiology and Genetics.
Mobley HLT, Mendz GL, Hazell SL, editors.
Washington (DC): ASM Press; 2001.
Copyright © 2001, ASM Press.

NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.