Figure 2

Figure 2

. Space-filling model of the predicted urease crystal structure. The primary amino acid sequence of H. pylori urease was overlaid onto the solved crystal structure of Klebsiella aerogenes urease (49, 50). The front (A) and back (B) views of the two subunits, UreA (dark) and UreB (light) are shown. Note the two nickel atoms inserted into the enzyme active site (panel B). The holoenzyme is composed of six copies of the heterodimer displayed in the figure; the crystal structure of the H. pylori urease has not been determined directly (figure designed by Ron Guiles and Nereus Gunther, University of Maryland).

From: Chapter 16, Urease

Cover of Helicobacter pylori
Helicobacter pylori: Physiology and Genetics.
Mobley HLT, Mendz GL, Hazell SL, editors.
Washington (DC): ASM Press; 2001.
Copyright © 2001, ASM Press.

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