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Figure 13.6. The amount (units in ng) of MAb IIB4 required to impose 50% neutralization (VN50) of influenza grown in cell culture.

Figure 13.6

The amount (units in ng) of MAb IIB4 required to impose 50% neutralization (VN50) of influenza grown in cell culture. Each observation (open circle) shows the neutralization of a different influenza strain with variant amino acids at the antibody binding site. The amino acid variants cause different equilibrium binding affinities (Ka) with the antibody (units in l/mol). The percent occupancy describes the fraction of HA spikes occupied by antibody under equilibrium conditions at 50% neutralization. Redrawn from Kostolanský et al. (2000), with permission from the Society for General Microbiology.

From: Chapter 13, Experimental Evolution: Influenza

Cover of Immunology and Evolution of Infectious Disease
Immunology and Evolution of Infectious Disease.
Frank SA.
Princeton (NJ): Princeton University Press; 2002.
Copyright © 2002, Steven A Frank.

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