Chapter 20Cancers

Sitas F, Parkin M, Chirenje Z, et al.

Cancer has received low priority for health care services in Sub-Saharan Africa. The reason is undoubtedly the overwhelming burden of communicable diseases, as illustrated by the proportions of deaths by major categories. Table 20.1 shows estimates, for Africa and for the whole world, made by the World Health Organization (WHO) of the percentages of deaths due to different causes in the year 2002 (WHO 2004).

Table 20.1. Estimated Percentages of Deaths, by Cause, 2002.

Table 20.1

Estimated Percentages of Deaths, by Cause, 2002.

From a purely objective point of view, therefore, concentration on health problems in Africa that have been largely solved in the developed world (infant and child mortality, maternal mortality, infectious diseases) appears eminently reasonable. Unfortunately, these "old" diseases coexist in Africa with the emergence of new ones, most prominently the acquired immune deficiency syndrome (AIDS), but also some of the noncommunicable diseases, such as hypertension, diabetes, accidents and violence (Motala 2002; Reza, Mercy, and Krug 2001; Seedat 2000; Walker et al. 2000), and cancer. Cancer is not a rare disease in Africa. Even ignoring the huge load of AIDS-related Kaposi's sarcoma, the probability that a woman living in present-day Kampala or Harare will develop a cancer by the age of 65 years is only about 20 percent lower than that of her sisters in Western Europe (table 20.2). Yet the facilities for providing treatment for cancer cases in most of Africa are minimal, as illustrated by the sparse distribution of radiation therapy services in Africa (figure 20.1) (Levin, El-Gueddari, and Meghzifene 1999).

Table 20.2. Cumulative Incidence of Cancer in Women up to 64 Years of Age, 1993–97.

Table 20.2

Cumulative Incidence of Cancer in Women up to 64 Years of Age, 1993–97.

Figure 20.1

Figure 20.1

Distribution of Radiation Therapy Services in Africa Source: Levin, El-Gueddari, and Meghzifene 1999.

The noncommunicable diseases, such as cancers, are emerging health problems that need to be dealt with appropriately to sustain public health advances that have already been achieved. Increases in the prevalence of tobacco consumption and immunosuppression induced by the human immunodeficiency virus (HIV), coupled with such existing risk factors for cancer as alcohol; the high prevalence of cancer-associated infectious agents like human papillomaviruses (HPV), hepatitis B viruses (HBV), and human herpesvirus-8 (HHV8); and environmental exposure to toxins, such as aflatoxins, will have an important impact on future cancer patterns and incidence. Even despite declining overall life expectancy as a result of the HIV epidemic, Africans will continue to age, which will contribute to cancer's becoming an increased burden on health services, both in relative and absolute terms.

Until quite recently, knowledge of cancer patterns was based primarily on clinical and pathological case series from the 1950s and 1960s, which were the subject of several reviews that drew together information on the relative frequency of different types of cancer in different areas in order to piece together an overall picture (Clifford, Linsell, and Timms 1968; Cook and Burkitt 1971; Oettlé 1964). Statistics on disease mortality are particularly sparse. Only about 0.25 percent of the population of Sub-Saharan Africa is covered by accurate death registration systems. The countries that have reasonably accurate death registration include islands like Mauritius and the Seychelles, which are unlikely to be representative of the region, and no country on the mainland of Sub-Saharan Africa has data of sufficient quality for the estimation of national mortality rates (Mathers et al. 2005). Hence, reliance has to be placed on indirect measures of mortality and on the few cancer registries that do exist across Africa, now covering roughly 8 percent (Parkin et al. 2003) of this population. An exception to this has been South Africa, which until 1990 had almost complete death notification for whites, mixed race "coloureds," and Asian Indians, comprising about 20 percent of the population. Population group identifiers on death notification forms were removed in 1991 but reintroduced in 1998. National coverage of deaths in South Africa across all populations has now increased to over 90 percent (Dorrington et al. 2001).

Since the 1990s there has been a resurgence of interest in cancer incidence in Africa, and data from cancer registries from Sub-Saharan Africa have been published from West Africa in The Gambia (Bah et al. 2001), Mali (Bayo et al. 1990), Guinea (Koulibaly et al. 1997), and Côte d'Ivoire (Echimane et al. 2000). Data from East Africa are available from cancer registries in Kampala, Uganda (Wabinga et al. 2000), and from southern Africa from the Zimbabwe Cancer Registry in Harare (Chokunonga et al. 2000), and the Malawi Cancer Registry in Blantyre (Banda et al. 2001).

Cancer registration in economically underdeveloped populations, such as all the countries of Sub-Saharan Africa, is a difficult undertaking for a variety of reasons (Parkin et al. 2003). The major challenge is to ensure that all new cases of cancer are identified. Cases can be found only when they come into contact with health services: hospitals, health centers, clinics, and laboratories. When resources are restricted, the proportion of the population with access to such institutions may be limited, and the statistics generated will thus not truly reflect the pattern of cancer. The ease with which the cases can be identified also depends on the extent of medical facilities available and the quality of statistical and record systems already in place (for example, pathology request forms, hospital discharge abstracts, treatment records, and so forth). It is impossible to know, without an extensive population survey, what proportion of those with cancer never come into contact with modern diagnostic or treatment services, instead making use only of traditional healers or receiving no care at all.

In the past, studies have suggested that some sections of the population may have been underrepresented in hospital statistics, particularly older women and young men, both of whom were more likely to return to their rural homes to seek care (Flegg Mitchell 1966). However, currently, this underrepresentation is probably rather rare in contemporary urban Africa. Most cancer patients will, eventually, seek medical assistance, although often at an advanced stage of disease. The situation in rural areas may be quite different, but almost all the present-day cancer registries are located in urban centers. From an epidemiological point of view, one must guess at how well the cancer profile from the urban areas reflects that in the country as a whole, given what is known of urban–rural differences in cancer patterns in other areas of the world.

The International Agency for Research on Cancer (IARC) has published the available data on cancer incidence and other cancer data from a variety of sources (Parkin et al. 2003). Such data have also been used to prepare a set of estimates of incidence and mortality at the national level for the year 2002 (Ferlay et al. 2005). These sources are extensively used in this chapter. We also draw upon the few available series from which it is possible to make some inferences about temporal trends in cancer incidence: the two cancer registries with data available in the 1960s—Kampala (Uganda) and Ibadan (Nigeria)—and the mortality data sets from South Africa referred to earlier.

According to the 2002 estimates of cancer incidence for the Sub-Saharan Africa region, about half a million (530,000) new cases of cancer occurred annually, 251,000 in males and 279,000 in females. Table 20.3 shows the leading cancer types by region (including the northern Africa region) and by sex. Figure 20.2 shows the major cancer types in Sub-Saharan Africa; overall, world-standardized cancer rates were estimated to be 133 per 100,000 females and 136 per 100,000 males.

Table 20.3. Estimated Number of New Cases and Age-Standardized (World) Incidence Rates for the Leading Cancers in Males and Females, 2002 (per 100,000 people).

Table 20.3

Estimated Number of New Cases and Age-Standardized (World) Incidence Rates for the Leading Cancers in Males and Females, 2002 (per 100,000 people).

Figure 20.2

Figure 20.2

Major Cancer Types in Sub-Saharan Africa, Both Sexes, All Ages Source: Adapted from Ferlay et al. 2004.

The top six cancers in males were the following:

  • Kaposi's sarcoma (15.9 percent)
  • liver (13.3 percent)
  • prostate (10.7 percent)
  • esophagus (6.0 percent)
  • non-Hodgkin's lymphoma (5.8 percent)
  • stomach (4.5 percent).

In females, the following were the leading cancers:

  • cervix (25.4 percent)
  • breast (17.4 percent)
  • Kaposi's sarcoma (6.2 percent)
  • liver (5.5 percent)
  • stomach (3.8 percent)
  • non-Hodgkin's lymphoma (3.8 percent).

Each of these cancers is briefly discussed in this chapter. In addition, tobacco-related cancers (especially lung cancer, which currently ranks seventh in males) and HIV-related cancers (cancers aside from Kaposi's sarcoma) are discussed, as these are likely to increase over time as both these epidemics mature.

Cervical Cancer

Cancer of the cervix is the leading cancer in women in Sub-Saharan Africa with an estimated 70,700 new cases occurring in 2002 (the total in the whole continent was 78,900 cases). Estimated rates for eastern and southern Africa of 30 to 60 per 100,000 are higher than those found in the rest of Sub-Saharan Africa (20 to 35 per 100,000), but the reasons for this difference are unclear. In many developed countries, such as the United Kingdom and Sweden, mortality from cancer of the cervix declined between the early 1900s and the 1960s and then declined further as a result of the introduction of national screening programs (Bergstrom, Sparen, and Adami 1999). However, in Bulawayo between 1963 and 1977 and in Kampala in the 1960s, 1970s, and 1990s, cancer of the cervix has appeared to increase in incidence over time (Skinner et al. 1993; Wabinga et al. 2000). No increases over time were observed in Nigeria and South Africa (Parkin et al. 2003).

It was noted early that cervical cancer has quite marked differences in incidence according to classical demographic variables (social class, marital status, ethnicity, religion). Later, epidemiological studies (mainly case-control studies) showed a consistent association between risk and early age at initiation of sexual activity, increasing number of sexual partners of females or of their sexual partners, and other indicators of sexual behavior. These findings were strongly suggestive of a causative role for a sexually transmitted agent. It is now recognized that certain sexually transmitted oncogenic human papillomaviruses constitute the necessary cause of cervical cancer. However, additional independent risk factors include increasing number of pregnancies, exposure to oral contraceptives, smoking, and specific dietary patterns.

At the onset of the AIDS epidemic, cancer of the cervix was classified as an AIDS-defining cancer by the U.S. Centers for Disease Control and Prevention (CDC 1993). But it is far from clear that HIV infection really increases the risk of invasive cervical cancer. No change in cervical cancer incidence has been demonstrated in some centers like Harare, where HIV/AIDS has been endemic for some time (Chokunonga et al. 1999). In Kampala the increase in cervical cancer incidence began before the advent of AIDS (Wabinga et al. 2000). With respect to cervical intraepithelial neoplasia (CIN), most studies failed to adjust for the fact that, for obvious reasons, women infected by HIV were very often also infected by HPV (with a consequently high risk of CIN). Careful adjustment for such confounding suggests that HIV has an independent effect on risk of CIN but that it is small; there is an interaction between the effects of HIV and HPV, as might be expected, if the role of HIV is indirect, through creation of immune suppression and dysfunction (Mandelblatt et al. 1999).

Case-control and descriptive studies on cancer of the cervix in Africa have shown associations of the disease similar to those observed in Western countries with respect to number of partners, level of education, high parity, and steroid contraceptives; however, genital hygiene, vaginal discharge, alcohol, and male circumcision were also found in certain studies to be important (Parkin et al. 2003). HIV was found to be associated with cervical cancer in case-control and cohort studies in South Africa and Uganda (Mbulaiteye et al., forthcoming; Newton et al. 2001; Sitas et al. 2000) with odds ratios between 1.6 and 2.4; however, such a weak association could easily be due to confounding by sexual activity, and other studies have shown no association (Newton et al. 1995; Sitas et al. 1997; ter Meulen et al. 1992). With regard to HPV, subtypes 16, 18, and 31 appear to be the leading ones, but other sexually transmitted infections causing chronic cervico-vaginal inflammation may increase the risk of cervical cancer.

Before the introduction of screening programs in the 1960s and 1970s, the incidence in most of Europe, North America, and Australia and New Zealand was much as we see it in Africa today: it was 38 per 100,000 in the Second National Cancer Survey of the United States, for example (Dorn and Cutler 1959). National screening programs have been responsible for the further decline in the incidence of cancer of the cervix. Pap test screening, with coverage of over 80 percent of the female population over 35 years of age appears to be the most effective method in reducing the incidence of cervical cancer. For example, if women were offered screening three times in their lifetime (at about ages 35, 45, and 55) the incidence of cancer of the cervix would be halved (Miller 1992).

Given the complex organization of screening programs, no organized national cervical cancer screening program exists in Africa. Reasons for this include lack of good quality cytology services, difficulty of long-term follow-up in many communities, lack of education, and lack of postal facilities and infrastructure. But many countries in Sub-Saharan Africa do not have the ability to diagnose or treat CIN. In other countries some attention has been given to the value of screening by visual inspection after acetic acid impregnation of the cervix (University of Zimbabwe/JHPIEGO Cervical Cancer Project 1999). The high negative predictive value of this approach suggests that few significant lesions will be missed. If appropriately and safely treated by effective, affordable methods like cryotherapy (Chirenje et al. 2001), then this method may provide a useful alternative to the conventional Pap test, not least in that treatment is provided during the same visit as the screening test, thus dispensing with the requirement to recall women for diagnosis and therapy.

Vaccines against the leading HPV serotypes have now been developed, and programs may be implemented for women before they become sexually active. However, it is unclear how long the protection will last and whether the vaccine will also be effective in reducing the incidence of cancer of the cervix among women who are infected. The ongoing trials are expected to clarify such issues. As men are also carriers of HPV, future studies ought to measure any added effectiveness of vaccination in this group.

Breast Cancer

Breast cancer is the second most common cancer among women in Sub-Saharan Africa, accounting for 16.8 percent of all female cancers. Central, West, and East Africa appear to have lower incidence rates than southern Africa, the latter estimated at 33.4 per 100,000. An estimated total of 48,600 cases occurred in Sub-Saharan Africa in 2002.

Worldwide, risk factors for female breast cancer include menstrual and reproductive factors, high body mass index (BMI), family history of breast cancer, and certain genetic mutations, including BRCA1/2. Other suggested risk factors include, to a much lesser extent, high alcohol consumption, contraceptive use, and the use of certain postmenopausal hormone replacement therapies. Reproductive and hormonal factors appear to be the most important, with risk being increased by early menarche, late menopause, late age at first birth, and low parity (Henderson, Ross, and Bernstein 1988).

Studies in Sub-Saharan Africa have also found reproductive and hormonal factors to be important, reporting increased risk with advanced age at first pregnancy and delivery, low parity, and late age at menarche (Adebamowo and Adekunle 1999; Coogan et al. 1996; Shapiro et al. 2000; Ssali, Gakwaya, and Katangole-Mbidde 1995).

In Sub-Saharan Africa, higher incidence rates and relative frequencies of breast cancer have been reported in association with urban than with rural residence (Oettlé and Higginson 1966; Schonland and Bradshaw 1968), but data are sparse. The incidence of breast cancer is much higher among white women in Africa than among black African women; for example, in Harare between 1993 and 1995, the incidence was 127.7 per 100,000 in whites and 20.4 in blacks (Chokunonga et al. 2000). These differences may be a reflection of the distribution of lifestyle factors thought to be important in the development of breast cancer, for example, low parity and high body mass.

Breast cancer risk has been associated with socioeconomic status, with women of higher social class (as measured by education, income, housing, and so forth) having a higher risk (Kogevinas et al. 1997). Once again, such differences are most likely a reflection of different prevalences of risk factors among social classes (for example, parity, age at menstruation and menopause, height, weight, alcohol consumption).

The effect of oral contraceptive hormones on the risk of breast cancer has been the subject of much research. There appears to be a small but detectable risk in women currently using oral contraceptives, but this diminishes when contraception ceases, and after 10 years, none of the excess risk remains (Reeves 1996). A case-control study in South Africa found that combined oral contraceptives may result in a small increase in risk, confined to women below the age of 25 years, but that injectable progesterone contraceptives did not increase risk (Shapiro et al. 2000).

Dietary fat appears to be correlated with the risk of breast cancer in interpopulation studies (Prentice and Sheppard 1990), but the association has been difficult to confirm in studies of individuals (Hunter et al. 1996). However, obesity in postmenopausal women has been identified as a risk factor in Europe (Bergstrom et al. 2001) as well as in Sub-Saharan Africa (Adebamowo and Adekunle 1999; Walker et al. 1989). Although traditional diets in Africa are typically low in animal products, especially fat, and high in fiber (Labadarios et al. 1996; Manning et al. 1971), this pattern is being modified by urbanization and Westernization of lifestyles, which may lead to an increase in breast cancer incidence in African populations. A case-control study in Cape Town did not find a protective effect of breastfeeding on breast cancer (Coogan et al. 1999). However, in a meta-analysis of 47 studies from 30 countries breastfeeding appears to be protective; based on a reanalysis of about 50,302 cases and 96,973 controls, two-thirds of the difference in rates between developed and developing countries were estimated to be attributed to breastfeeding (International Collaboration on HIV and Cancer 2002).

At least part of the familial risk of breast cancer is mediated through the major susceptibility genes BRCA1 and BRCA2 (about 2 percent of breast cancer cases in Europe). Very little is known of the prevalence of these mutations in African populations, although family history of breast cancer is also a risk factor in this setting (Rosenberg et al. 2002).

About 1 percent of all breast cancer cases occur in men, with the male-to-female ratio being higher in black and African populations than among white populations (Parkin et al. 2003; Sasco, Lowels, and Pasker de Jong 1993).

A review of the literature indicates a deficit of studies on breast cancer risk in Sub-Saharan Africa, and further research could be beneficial. As certain groups become more Westernized and urbanized, with associated changes in diet, later childbirth, and reduced parity and periods of breast-feeding, breast cancer incidence may increase. Public health campaigns should encourage breastfeeding unless there are good reasons not to (for example, HIV-infected mothers where milk powder and sterile water are freely available). There is no organized mammography screening program in Sub-Saharan Africa.

Kaposi's Sarcoma

Prior to the HIV/AIDS era, Kaposi's sarcoma was a rare cancer in Western countries, seen mainly among immigrants from the Mediterranean littoral and African regions and in immunosuppressed transplant recipients. Meanwhile, in Africa, the incidence of Kaposi's sarcoma varied 100-fold, being most common in central and eastern Africa and rare in northern and southern Africa (IARC 1996; Oettlé 1962); in certain parts of central and eastern Africa, Kaposi's sarcoma was as common as cancer of the colon was in the West (Cook-Mozaffari et al. 1998). There appears to be some geographical association with the prevalence of human herpes virus-8, now regarded as a necessary cause for the development of Kaposi's sarcoma (Dukers and Rezza 2003). The incidence of Kaposi's sarcoma has increased over 1,000-fold in populations at high risk of HIV in some Western countries (Biggar et al. 1984; Rabkin, Biggar, and Horm 1991), but in the rest of the population the tumor still remains relatively rare (Grulich, Beral, and Swerdlow 1992; Rabkin, Biggar, and Horm 1991). In Africa, since the 1980s, areas like Malawi, Swaziland, Uganda, and Zimbabwe, where Kaposi's sarcoma was relatively common before the era of AIDS, the incidence of Kaposi's sarcoma has increased about 20-fold, such that it is now the leading cancer in men and the second leading cancer in women. In these cancer registries, overall age-standardized rates have increased by about 15 percent, mainly as a result of HIV-associated Kaposi's sarcoma (for example, Bassett et al. 1995; Wabinga et al. 1993; Wabinga et al. 2000).

According to the most recent estimates, 40,000 cases of Kaposi's sarcoma in males and 17,200 cases in females were estimated for 2002 for Sub-Saharan Africa; only 200 male and 65 female cases were estimated to occur in northern Africa. The region most affected is central Africa (age-standardized rates in males of 30 per 100,000) followed by eastern, southern, and lastly western Africa, in line with the background prevalence of HIV in each of these regions. With regard to the effect of HIV infection, three case-control studies from Africa showed increased risks of 30 to 50 in association with HIV, and these risks rise to 1,600 in HIV-positive individuals with high HHV8 antibody titers (Newton et al. 2002; Sitas et al. 1997; Sitas et al. 1999; Sitas et al. 2000). HHV8 in adults is associated with increasing age, low educational standard, and increasing numbers of sexual partners (Sitas et al. 1999). Antiretroviral therapy for treating HIV in adults has caused a decline in the incidence of Kaposi's sarcoma in Western countries (International Collaboration on HIV and Cancer 2000). HHV8 in children appears to be associated with infected mothers (Bourboulia et al. 1998). In countries with a high prevalence of HIV, Kaposi's sarcoma is now the leading cancer in children, causing almost a doubling in the childhood cancer incidence (Chokunonga et al. 1999; Wabinga et al. 1993). Antiretroviral drugs have now become more available in Botswana and recently in South Africa. If their use becomes widespread, then a decline in the incidence of Kaposi's sarcoma would be expected; however, it is unclear whether antiretrovirals (for example, zidovudine [AZT] or nevirapine) issued to mothers during delivery, which proved effective in reducing mother-child transmission of HIV, would cause a decline in Kaposi's sarcoma in children.

Stomach Cancer

A total of 13,800 cases of stomach cancer in males and 10,700 in females was estimated in Sub-Saharan Africa in 2002. Age-standardized incidence rates in males varied, per 100,000, from 3.4 in western Africa to 7.4 in eastern, 8.2 in southern, and 13.4 in central Africa. In western Africa, where the incidence of stomach cancer is the lowest, the male-to-female ratio is 0.9 to 1; however, there is a male predominance in all other areas (table 20.3). Despite the generally low incidence rate in Africa, some populations have a particularly high incidence rate. Clusters of high incidence exist among the South African mixed race, or coloured, population of 98 per 100,000. A high incidence rate is also reported in the Great Lakes region that includes Burundi, Kivu Province of the Democratic Republic of Congo, Rwanda, northwestern Tanzania, and southwestern Uganda. In Rwanda the age-standard incidence rate was found to be 13 per 100,000 males and 15 per 100,000 females (Newton et al. 1996). In western Uganda, stomach cancer was the second most common cancer, accounting for 12 percent of all male cancers and 6 percent of all female cancers (Wabinga et al. 2000). Bamako in Mali was another area with a high incidence rate: 18.5 per 100,000 males and 15 per 100,000 females (Bayo et al. 1990).

There is evidence of a slight but not significant increase in the incidence of stomach cancer over time in Kampala (Wabinga et al. 2000). In Kivu Province of the Democratic Republic of Congo, the incidence rates of stomach cancer among males and females were 9 and 15 per 100,000, respectively, in 1956–60, but this dropped to 6 and 4.5 per 100,000 in 1983–86 (Bourdeaux et al. 1988; Clemmensen, Maisin, and Gigase 1962). However, in rural Kenya reported incidence increased as a result of an endoscope acquired by the main hospital there (McFarlane et al. 2001). Trend data from the rest of Africa are incomplete or inconsistent; however, in South Africa, between 1948 and 1964 no real change in the relative frequency of stomach cancer was observed over time in one of the country's largest hospitals serving the predominantly black population of Soweto, Johannesburg (Robertson 1969), nor was a change observed in pathology-based cancer national registrations between 1986 and 1995 (Sitas, Madhoo, and Wessie 1998).

Helicobacter pylori infection is now recognized as an important risk factor for cancer of the stomach (IARC 1994); however, smoking and diets low in fruit and vegetables and vitamin C, and high in salts appear to play an important role. Many studies have shown the prevalence of H. pylori in Africa to be about 80 percent and that infection is acquired at a younger age than in Western countries (for example, Sathar et al. 1994). Chronic atrophic gastritis and intestinal metaplasia of the stomach are two key lesions in the natural history of stomach cancer. Very few studies in Sub-Saharan Africa have measured the association between gastric mucosal pathology and H. pylori. In summary, even in a continent where the prevalence of H. pylori is high, differences exist in the prevalence of H. pylori between those with a normal mucosa (0–33 percent) and those with gastritis of any kind. Needless to say, the prevalence of gastritis (mild or moderate) is high, but the prevalence of severe or chronic atrophic gastritis or intestinal metaplasia is low (Parkin et al. 2003). Two case-control studies from Africa show an association between H. pylori and stomach cancer, but the relative risks are low, probably because the mucosa of patients with gastric cancer is unfavorable to the survival of H. pylori (Jaskiewicz et al. 1989; Louw et al. 2001). CagA positive strains, usually associated with more severe gastric pathology and outcomes, are the predominant strains in Africa (Ally et al. 1998), but their role in gastric carcinogenesis is unclear. Certain vacA genotypes appear to be more common in patients with gastric cancer (Kidd et al. 1999) and seem to be independent risk factors for the disease; however, no studies have been done in Sub-Saharan Africa on the relation between stomach cancer, host susceptibility (in relation to inflammatory cytokines), and the other risk factors known to be associated with stomach cancer (for example, diet, salt, smoking, and pickled foods) (see, for example, Coggon et al. 1989). There are many places in Africa where food is salted or pickled to aid preservation, but the relative importance of these risk factors in local settings is unknown.

Liver Cancer

Early observations in Africa have always noted the high occurrence of liver cancer (for example, Oettlé 1964), and it is still one of the leading cancer types in men and women, although the relative frequency has been reduced in consequence of the large increase in the number of cases of Kaposi's sarcoma resulting from the epidemic of HIV/AIDS. Liver cancer is now the second leading cancer in men in Sub-Saharan Africa and the fourth leading cancer in women (table 20.3). There were an estimated total of 33,500 cases in males and 15,500 cases in females in 2002. Areas of high liver cancer incidence (mainly hepatocellular cancers) include countries like The Gambia, Guinea, and Senegal in West Africa, where liver cancers comprise a quarter or more of all cancer cases, with incidence rates ranging from 30 to 50 per 100,000 in men and 12 to 20 per 100,000 in women. Similarly, in central Africa, liver cancer is the leading cancer in Rwanda and in the Republic of Congo (Brazzaville); the estimated rate is 15.4 per 100,000 for men and 8.9 per 100,000 for women. Mozambique is reported to have high incidence rates, although the only data are old (Prates and Torres 1965).

Few places in Sub-Saharan Africa have information on cancer trends over time. In Ibadan, Nigeria, between 1960–69 and 1998–99, there appears to be no change in incidence, whereas in Kampala, Uganda, between the 1960s and the 1990s there appears to be a decline of liver cancer in men but not in women. However, a decline was noted in liver cancer incidence between the 1970s and the 1980s among Mozambican miners working in South Africa (Harington, Bradshaw, and McGlashan 1983).

Chronic carriage of HBV or hepatitis C (HCV), causing cirrhosis, or chronic hepatitis is the leading risk factor for liver cancer. The prevalence of HCV in Sub-Saharan Africa varies between 6.9 percent in central Africa to 0.1 percent in southern Africa (table 20.4). HCV transmission is probably via blood transfusion, unsterile medical and dental procedures, and traditional practices, such as scarification; sexual transmission is thought to be rare (Madhava, Burgess, and Drucker 2002).

Table 20.4. Prevalence of Hepatitis C Virus IgG Antibodies in Sub-Saharan Africa, 2000.

Table 20.4

Prevalence of Hepatitis C Virus IgG Antibodies in Sub-Saharan Africa, 2000.

Persistence of the HBV surface antigen (HbsAg) in blood is an indicator of chronic carriage of HBV infection. The risk of liver cancer in persons with chronic HBV infection, as indicated by the detection of HbsAg in serum, ranges from 6- to 20-fold in different studies, and it is estimated that about two-thirds of liver cancer in Africa is attributed to HBV (Pisani et al. 1997). Prevalence rates in Africa are over 10 percent in central, western, and eastern Africa and between 5 and 10 percent in southern Africa (Parkin et al. 2003).

There are relatively few African studies on the risk of HCV infection on the development of liver cancer. Those that have been conducted give relative risks ranging from 1.1 to 62 (Parkin et al. 2003). One study (Kirk et al. 2004) observed that, as has been found elsewhere, the risk of chronic infection by HCV and HBV is additive, suggesting common mechanisms of carcinogenesis.

Aflatoxin B1 (AFB1) is produced by molds of Aspergillus sp. that are common contaminants of poorly stored grains. AFB1 is a known liver carcinogen of animals and humans (IARC 1993, 2002). In Sub-Saharan Africa, high levels of AFB1 contamination are found in groundnuts and, to a lesser extent, corn. Contamination of groundnuts by AFB1 is quite widespread and frequently exceeds thresholds permitted in exports to most developed countries. Several geographical studies have demonstrated correlations between AFB1 levels and the incidence of hepatocellular cancer (see Parkin et al. 2003).

Iron overload, derived from food and drink preparation in iron vessels, is a common condition in rural Africa, and there have been several observations that elevated serum ferritin levels are associated with liver cancer. In one small case-control study in South Africa (Mandishona et al. 1998), liver cancer cases had higher iron overload levels than controls, corresponding to an odds ratio of 10.6 to 4.1 (depending on the control group used).

Smoking, oral contraception, and alcohol consumption (IARC 2004, 1999, and 1988, respectively) were also found to be important risk factors for liver cancer. This association, however, has not been extensively examined in Africa.

Early vaccine trials against HBV suggest that 70 to 75 percent of chronic infections could be prevented. A randomized trial to measure the effectiveness of HBV vaccination in the prevention of liver cancer is under way in The Gambia, but it will take many years before results are available. In Taiwan, however, children born after the introduction of mass vaccination had a fourfold lower incidence than those born before its introduction (Chang et al. 1997). According to the WHO Web site, by 2002, about a dozen countries in Sub-Saharan Africa had introduced hepatitis B vaccine into their infant immunization system (http://www.who. int/vaccines-surveillance/graphics/htmls/HepBvaccine UseMar02.htm).

Aflatoxin consumption could be reduced by improved education of individuals and farmers by, for example, agricultural extension officers. A trial in western Africa has shown that improved post-harvest storage of groundnuts can significantly reduce aflatoxin exposure in rural populations (Turner et al. 2005). The public could be educated to avoid contaminated peanuts sold by vendors (Wild and Hall 2000). Companies manufacturing peanut butter could be better controlled by accepting peanuts only from certified farmers and by the testing of their products by independent regulatory authorities.

Prostate Cancer

For the year 2002, a total of 26,800 cases of prostate cancer were estimated, comprising 10.6 percent of cancers of men in Sub-Saharan Africa (Ferlay et al. 2005). The relatively high incidence (and mortality) recorded in African populations is reflected in populations of African descent elsewhere. Thus, within the United States, the black population has the highest incidence (and mortality) rates, some 72 percent higher than whites. Southern Africa appears to have the highest rates (40.5 per 100,000). Rates of histologically diagnosed prostate cancer in South Africa are 40.1 per 100,000 in whites versus 14 per 100,000 in blacks, although for blacks, access to diagnostic facilities has been limited (Parkin et al. 2003). In Zimbabwe (defined as being part of eastern Africa), rates for whites and blacks were 70 versus 25 per 100,000 (Parkin et al. 2003). Central Africa follows with rates of 24.5 per 100,000. Surprisingly, in West Africa, where the majority of African-American men originated, the incidence rate of prostate cancer was estimated as 19.3 per 100,000 in 2002, compared with about 125 per 100,000 in the United States (Ferlay et al. 2005). High rates are observed in other places with populations that are descended from West Africa (for example, the Bahamas, Barbados, Trinidad).

Histology of the prostate in elderly men often reveals latent malignant cells, and clearly, advances in diagnostic and screening methods can cause artificial increases in reporting. This is illustrated by a fourfold increase in the incidence of histologically verified prostate cancer among whites in South Africa (most whites were covered by private health insurance) compared with no change in incidence in blacks between 1986 and 1995 (Sitas, Madhoo, and Wessie 1998). Notably, in Cape Town in the 1950s prostate cancer appeared to be more common in blacks than in whites (Muir-Grieve 1960). Increases over time have also been noted in Kampala and in Ibadan, but it is unclear how much of these increases represents a greater risk and how much can be attributed to increased awareness or a greater readiness to perform prostatectomy for urinary symptoms in elderly men (Parkin et al. 2003).

The consumption of fat and red meat has been implicated as a risk factor for prostate cancer in studies in developed countries, even though adjustment for total caloric intake was not always done. Associations with vegetable consumption have been inconclusive. Associations with anthropometric measures or a link with obesity have been inconclusive, and so have associations with numbers of sexual partners and history of sexually transmitted diseases, or STDs (Hayes et al. 2000; Key 1995; Kolonel 1996). In one case-control study from South Africa, prostate cancer was associated with high intake of fat, meat, and eggs; eating out of the house; and a low consumption of vegetables (Walker et al. 1992).

Sex hormones, modulated by polymorphisms on the long arm of chromosome X, play an important role in the development of prostate cancer (for example, Ross et al. 1998; Shibata and Whittemore 1997). Polymorphisms on the androgen receptor gene may vary by ethnic group and may provide some explanation for the geographic variation observed. However, no studies have been done on interethnic variations in androgen receptor polymorphisms in Africa.

Non-Hodgkin's Lymphoma

The non-Hodgkin's lymphomas are composed of an extremely heterogeneous group of lymphoproliferative malignancies displaying distinct behavioral, prognostic, and epidemiological characteristics. Advances in molecular biology, genetics, and immunology have resulted in extensive changes in the classification of lymphoid tumors in the last few decades. The WHO classifies tumors according to cell lineage defined by immunophenotype (Jaffe et al. 2001). Three broad categories are now recognized: B-cell neoplasms, T/NK-cell neoplasms, and Hodgkin's lymphoma. Lymphocytic leukemias fall within the B-cell neoplasm group.

A total of 14,500 cases in males (5.8 percent of all cancers) and 10,600 cases in females (3.8 percent of all female cancers) were estimated for 2002 in Sub-Saharan Africa. In most African populations non-Hodgkin's lymphoma is relatively rare, but the relative frequency is above the world average in North and Sub-Saharan Africa because of the high incidence of Burkitt's lymphoma in children in the tropical zone of Africa. As in Western countries, most non-Hodgkin's lymphomas in Africa are of B-cell type. In adults, clinical series show an excess of high-grade lymphomas and a deficit of nodular lymphomas.

Human T-cell lymphotrophic viruses (for example, HTLV-I) are common in tropical Africa (IARC 1996) and are a cause of T-cell lymphomas; however, the incidence of these in Africa is low. Although Epstein-Barr virus DNA may be found in a small proportion of lymphomas, its role in causing non-Hodgkin's lymphomas is unclear (IARC 1997). HCV infection has been implicated in B-cell non-Hodgkin's lymphomas in some studies; the postulated mechanism being through the stimulation of polyclonal proliferation of B cells (reviewed by Parkin et al. 2003). HIV infection has been associated with 60-fold increased risks of developing non-Hodgkin's lymphomas in Western countries (for example, Beral et al. 1991); approximately 5 to 10 percent of HIV-infected persons will develop a lymphoma, and non-Hodgkin's lymphoma is the AIDS-defining illness in about 3 percent of HIV-infected patients (Remick 1995). In Africa, however, the association between HIV and non-Hodgkin's lymphoma has been in the region of 2.3 to 12.3 (Mbulaiteye et al., forthcoming; Newton et al. 2001; Parkin et al. 2003; Sitas et al. 1997; Sitas et al. 2000). The reason for the discrepancy in the association between HIV and non-Hodgkin's lymphoma between developed countries and Africa is unclear. Non-Hodgkin's lymphomas were increasing in incidence in Western populations before the advent of HIV but have increased dramatically in high-risk groups affected by HIV (see, for example, Schultz, Boshoff, and Weiss 1996). In Harare, Zimbabwe (Chokunonga et al. 1999), and in Kampala, Uganda, there is now evidence of an increase in incidence between earlier cancer registration periods and periods in the 1990s (Parkin et al. 1999; Parkin et al. 2003).

Burkitt's lymphoma affects mainly children between the ages of five and nine. The jaw is affected 50 to 60 percent of the time. Burkitt's lymphoma shows a peculiar geographic distribution and has been reviewed by others (for example, Burkitt 1969; Williams et al. 1978; Wright 1973). It accounts for about a quarter to a half of childhood cancers in the eastern and central parts of Africa and in tropical West Africa, and less frequently in other places. Burkitt identified a striking distribution 15 degrees north and south of the equator, with a southern tail into Mozambique. But even within this area Burkitt's lymphoma was rarer in higher altitudes. The areas where it was most common were typified by rainfalls over 50 centimeters per year and an average of the coolest month of greater than 15.6°C, which seem associated with the distribution of malaria endemicity (Burkitt 1969; O'Conor 1970). Low socioeconomic status, family clustering, and proximity to the plant species Euphorbia tirucalli have been suggested as important factors in the etiology of Burkitt's lymphoma; however, the leading agent has been infection with Epstein-Barr virus (IARC 1997).

In a follow-up study of 42,000 children, those who developed Burkitt's lymphoma had higher titers of antiviral capsid antigen than in matched controls (de Thé et al. 1978; Geser et al. 1982). The link with malaria appears to be a result of the loss of cytotoxic T-cell control due to dysfunction of a subset of CD4 cells responsible for the induction of suppressor-cytotoxic CD8 cells. This may result in uncontrolled proliferation of B cells containing the Epstein-Barr virus and resultant malignant transformation (for example, Pagano et al. 1992; Whittle et al. 1990). In a five-year period of malaria suppression (when chloroquine was issued to children under 10), Burkitt's lymphoma appeared to decline in incidence. Incidence returned to the original level after the five-year program was completed (Geser, Brubaker, and Draper 1989). Burkitt's lymphoma is much rarer in adults, although Burkitt-like (or high-grade Burkitt-like) lymphomas appear to be occurring with increased frequency as a result of HIV (Sitas et al. 2000).

A prevention program for non-Hodgkin's lymphomas can be carried out only after the taxonomy and causes are further elucidated. It appears that antimalarial programs may have a significant impact on Burkitt's lymphoma in children, and as in Western countries, widespread antiretroviral therapy of HIV-positive individuals would cause a decline in the incidence of non-Hodgkin's lymphoma.

Cancer of the Esophagus

In 2002 a total of 15,150 cases of cancer of the esophagus were estimated to occur in males in Sub-Saharan Africa and 7,200 cases in females. Cancer of the esophagus shows a remarkable geographic distribution, being one of the leading cancers in southern and East Africa (average incidence in males about 19 per 100,000) but rare in West Africa (1 to 2 cases per 100,000). Certain areas of high risk have been reported from Kenya and the former Transkei homeland in the Eastern Cape Province of South Africa, where incidence rates as high as 76.6 per 100,000 in males and 36.5 per 100,000 in females were reported between 1991 and 1995 (Somdyala et al. 2003). Several studies between the 1950s and the 1990s in South Africa, Uganda, and Zimbabwe have demonstrated that cancer of the esophagus has increased in incidence. But the latest available data from cancer registries in these countries show a declining trend in esophageal cancer incidence, particularly in males after 1990 (Parkin et al. 2003; Somdyala et al. 2003).

Tobacco and alcohol consumption, known risk factors for the development of esophageal cancer in many countries, have also been documented as important in Africa in studies conducted from the 1980s onward; earlier studies found no such association, probably because of the low alcohol concentration of noncommercial drinks. The net effect of increasing commercial alcohol consumption, combined with increases in some places of tobacco consumption, on esophageal cancer trends is to date unclear. There is no consistent evidence of an effect of homemade brews and esophageal cancer risk in Africa.

Esophageal cancer also appears to occur in areas of extreme poverty and poor nutritional status. The high incidence of esophageal cancer in the Transkei region of the Eastern Cape Province has been associated with the monotonous consumption of corn, which contains low levels of niacin, riboflavin, vitamin C, zinc, calcium, and magnesium (Van Rensburg 1981) and is sometimes contaminated with fungal toxins produced by Fusarium spp. Certain studies in this region have shown a geographical association with the presence of Fusarium moliniforme, a common fungal contaminant of poorly stored corn. Other risk factors reported in the Transkei include infections with Candida albicans and the consumption of a green, leafy plant weed, Solanum nigrum (Sammon 1992).

Other HIV-associated Cancers

Aside from Kaposi's sarcomas and non-Hodgkin's lymphomas, other cancers that appear to be associated with HIV immune suppression are cancer of the conjunctiva and possibly cancers of the cervix, vulva or vagina, anus, and liver (IARC 1996). However, except for conjunctival cancers, the data, at least from Sub-Saharan Africa, are not yet conclusive (IARC 1996; Parkin et al. 2003). Conjunctival cancers are increasing in incidence in Malawi (Banda et al. 2001);Uganda (Newton et al. 2001; Parkin et al. 1999), and Zimbabwe (Chokunonga et al. 2000); these countries have some of the most prolonged and highest levels of HIV prevalence in Africa, and it is anticipated that these cancers will increase in time in other places in Africa that are affected by HIV.

Tobacco-related Cancers

Tobacco smoking is by far the most important cause of lung cancer. The evidence has been reviewed many times (IARC 1986, 2004). In 1985 it was estimated that about 76 percent of all lung cancer worldwide (84 percent of cases in men and 46 percent in women) could be attributed to tobacco smoking (Parkin et al. 1994). However, in Africa, because smoking is a relatively recent habit in most areas, the proportion of tobacco-attributed lung cancers is low.

Only where the smoking habit has been established in a significant percentage of the population for a prolonged period of time is the proportion of tobacco-attributable cancers also significant—85 percent of cases in males in certain southern African populations and 68 percent in northern Africa, for example (Parkin and Sasco 1993).

Because of the lower incidence of lung cancer in Africa (and the low prevalence of tobacco consumption in most places in Africa) there is a widespread misconception that the hazards of tobacco are only relevant in developed countries. However, it appears that tobacco consumption, particularly of manufactured cigarettes, is increasing in Africa. Figure 20.3 shows the distribution of per capita consumption of cigarettes in Africa in countries where data exist. It is notable that aside from southern and northern Africa, consumption is low. Typical per capita consumption in the United States, for example, is 2,255 cigarettes, and in China, 1,791, per year. In a WHO survey it was found that between two decades, 1970–72 and 1990–92, 15 countries in Africa increased their consumption of cigarettes, 6 decreased, and 5 remained unchanged (WHO 1997). Data were unavailable for the rest of Africa. Adult smoking rates also vary significantly; prevalence in Africa among men varies from 10 to 50 percent, and among women from 1 to 10 percent (WHO 1997). An exception may be the mixed-race population of South Africa, where there has been a high prevalence (currently 40 to 50 percent) of smoking among women, and, indeed, lung cancer rates (and rates for other tobacco-associated cancers such as oral and esophageal cancers) are higher in southern Africa than the rest of Africa.

Figure 20.3

Figure 20.3

Number of Cigarettes Consumed per Adult Source:

Evidence of the recent effect of the tobacco epidemic in Africa comes from the Northern Province (mainly rural) of South Africa (Mzileni et al. 1999) and Soweto (urban South Africa) (Pacella-Norman et al. 2002). In the Northern Province, the relative risk that males would develop lung cancer if they smoked 15 cigarettes or more per day was 13, but in Soweto the relative risk for smoking the same number of cigarettes was 20.7. The latter relative risk is comparable to that observed in some developed countries.

In a study from South Africa, which uses the death registration system to ask the next of kin about the smoking status of the deceased, 61 percent of male and 48 percent of female deaths due to lung cancer were found to be attributed to smoking (compared with 80 to 90 percent in men and 30 to 70 percent in women in Western countries (Parkin and Sasco 1993). It was estimated that in all about 22,000 adult deaths (8 percent of total deaths compared with 15 percent of deaths in Western countries; Peto et al. 2004) were attributed to tobacco (Sitas et al. 2004). Surprisingly, more deaths from chronic obstructive pulmonary disease and tuberculosis would be expected from tobacco than deaths from lung cancer. The reason for the lower proportions of lung cancers attributed to smoking is that some of such cancers can be attributed to occupational exposures, environmental tobacco smoke, air pollution, and radon gas exposure (Parkin and Sasco 1993). Other tobacco-attributed cancers studied in Africa include those of the bladder, cervix, larynx, and esophagus and oral cancers (summarized in chapters in Parkin et al. 2003).


Over the past century, until about the 1980s (prior to the advent of HIV/AIDS), the average age of most populations in Sub-Saharan Africa has increased because of improvements in the rates of both infant and adult mortality (Timaeus 1999). Since cancer risk is strongly related to age, the aging population has experienced an increase in the numbers of cancers and in crude incidence. Cancer has therefore been an emerging public health problem. The HIV epidemic has arguably caused the biggest change in cancer patterns, with Kaposi's sarcoma now being the leading cancer type in men and the third most common cancer in women. But also, certain cancer types, such as cancer of the lung, breast, prostate, and esophagus, have increased significantly as a result of changing lifestyles and changes in exposures to common carcinogens.

Although the relative importance of many important carcinogens has been described for many cancers in most Western countries, little is known about the distribution of these and the relative importance of the major causes of cancer in Africa. Even in places with existing cancer registries, or well-resourced countries like South Africa, very few cancers or common carcinogenic exposures are being researched in a systematic fashion, and there is therefore wide uncertainty about their relative importance and their evolution over time. The relative importance of cancers and related exposures to them needs to be carefully assessed in order to formulate appropriate health promotion strategies. Given the tremendous variation in the genetics, lifestyle characteristics, and cancer patterns throughout Africa, it may be misleading to extrapolate cancer patterns from one area to the next, so better data from population-based cancer registries and from mortality statistics are needed to provide data of local relevance.

There have, however, been some positive developments. Compared with 1978–82, when no data from population-based cancer registries in Sub-Saharan Africa existed (Muir et al. 1987), the information derived from cancer registries in Sub-Saharan Africa now covers 8 percent of the population. Despite this great achievement most of these registries are staffed by a part-time director and one or two clerks, who do not know whether sufficient support will be forthcoming from their Departments of Health or other potential stakeholders. Given the short time that these registries have existed in Africa the impact of these on cancer incidence is still difficult to quantify. Yet long-term surveillance is necessary to quantify the impact of the epidemics of tobacco and AIDS and to evaluate the efficacy of cancer control measures.

Still, despite the dramatic reduction in life expectancy in many populations in Sub-Saharan Africa, age-standardized cancer incidence in these registries has remained the same, and in places where HIV prevalence is high, the overall incidence of cancer seems to have increased by up to 15 percent. This is counterintuitive to the common belief that a reduction in life expectancy due to HIV would cause a decline in chronic disease.


The authors are grateful to Ruth Lawrence for preparing the manuscript.


  1. Adebamowo C. A., Adekunle O. O. Case-Controlled Study of the Epidemiological Risk Factors for Breast Cancer in Nigeria. British Journal of Surgery. 1999;86(5):665–68. [PubMed: 10361191]
  2. Ally R., Hale M., Hadjinicolaou C., Sonnendecker H. E. M., Bardhan K. D. et al. Helicobacter Pylori in Soweto South Africa. CagA Status and Histopathology in Children. Abstract. Gastroenterology. 1998;114:A54.
  3. Bah E., Parkin D. M., Hall A. J., Jack A. D., Whittle H. Cancer in The Gambia: 1988–1997. British Journal of Cancer. 2001;84:1707–24.
  4. Banda L. T., Parkin D. M., Dzamalala C. P., Liomba N. G. Cancer Incidence in Blantyre, Malawi 1994–1998. Tropical Medicine and International Health. 2001;6(4):296–304. [PubMed: 11348520]
  5. Bassett M. T., Chokunonga E., Mauchaza B., Levy L., Ferlay J., Parkin D. M. Cancer in the African Population of Harare, Zimbabwe in 1990–92. International Journal of Cancer. 1995;63:29–36. [PubMed: 7558448]
  6. Bayo S., Parkin D. M., Koumare A. K., Diallo A. N., Ba T., Soumare S., Sangare S. Cancer in Mali, 1987–1988. International Journal of Cancer. 1990;45(4):679–84. [PubMed: 2323845]
  7. Beral V., Peterman T., Berkelman R., Jaffe E. S. AIDS-Associated Non-Hodgkin Lymphoma. Lancet. 1991;337:805–9. [PubMed: 1672911]
  8. Bergstrom A., Pisani P., Tenet V., Wolk A., Adami H. O. Overweight as an Avoidable Cause of Cancer in Europe. International Journal of Cancer. 2001;91(3):421–30. [PubMed: 11169969]
  9. Bergstrom R., Sparen P., Adami H. O. Trends in Cancer of the Cervix Uteri in Sweden Following Cytological Screening. British Journal of Cancer. 1999;81(1):159–66. [PMC free article: PMC2374360] [PubMed: 10487628]
  10. Biggar R. J., Horm J., Fraumeni J. F., Greene M. H., Goedert J. J. Incidence of Kaposi Sarcoma and Mycosis Fungoides in the United States Including Puerto Rico, 1973–1981. Journal of the National Cancer Institute. 1984;73:89–94. [PubMed: 6588239]
  11. Bourboulia D., Whitby D., Boshoff C., Newton R., Beral V., Carrara H., Lane A., Sitas F. Serologic Evidence for Mother to Child Transmission of Kaposi Sarcoma Associated Herpes Virus Infection. Journal of the American Medical Association. 1998;280(1):31–32. [PubMed: 9660357]
  12. Bourdeaux L., Renard F., Gigase P. L., Mukolo-Ndjolo, Maldague P., De Muynck A. L'incidence des cancers à l'hôpital de Katana, Kivu, Est Zaire, de 1983 à 1986. Ann. Soc. Belg. Med Trop. 1988;68:141–56. [PubMed: 3240009]
  13. Burkitt D. P. Etiology of Burkitt's Lymphoma—An Alternative Hypothesis to a Vectored Virus. Journal of the National Cancer Institute. 1969;42:19–28. [PubMed: 4303830]
  14. Centers for Disease Control Prevention (CDC) Revised Classification System for HIV Infection and Expanded Surveillance Case Definition for AIDS among Adolescents and Adults. Journal of the American Medical Association. 1993;269:729–30. [PubMed: 8093740]
  15. Chang M. H., Chen C. J., Lai M. S., Hsu H. M., Wu T. C., Kong M. S., Liang D. C., Shau W. Y., Chen D. S. Universal Hepatitis B Vaccination in Taiwan and the Incidence of Hepatocellular Carcinoma in Children. Taiwan Childhood Hepatoma Study Group. New England Journal of Medicine. 1997;336:1855–59. [PubMed: 9197213]
  16. Chirenje M., Rusakaniko V., Akino M., Mlingo Z. A Randomised Clinical Trial of Loop Electrosurgical Excision Procedure (LEEP) versus Cryotherapy in the Treatment of Cervical Intraepithelial Neoplasia. Journal of Obstetrics and Gynecology. 2001;21(6):617–21. [PubMed: 12521783]
  17. Chokunonga E., Levy L., Bassett M., Borok M. Z., Mauchazo B. G., Chirenje M. Z., Parkin D. M. AIDS and Cancer in Africa. The Evolving Epidemic in Zimbabwe. AIDS. 1999;13:2583–88. [PubMed: 10630528]
  18. Chokunonga E., Levy L. M., Bassett M. T., Mauchaza B. G., Thomas D. B., Parkin D. M. Cancer Incidence in the African Population of Harare, Zimbabwe: Second Results from the Cancer Registry 1993–1995. International Journal of Cancer. 2000;85(1):54–59. [PubMed: 10585583]
  19. Clemmensen, J., J. Maisin, and P. Gigase. 1962. "Preliminary Report on Cancer in Kivu and Rwanda-Urundi." University of Louvain, Institut de Cancer, Louvain.
  20. Clifford, P., C. A. Linsell, and G. L. Timms, eds. 1968. Cancer in Africa. Nairobi: East African Publishing House.
  21. Coggon D., Barker D. J., Cole R. B., Nelson M. Stomach Cancer and Food Storage. Journal of the National Cancer Institute. 1989;81(15):1178–82. [PubMed: 2746670]
  22. Coogan P. F., Clapp R. W., Newcomb P. A., Mittendorf R., Bogdan G., Baron J. A., Longnecker M. P. Variation in Female Breast Cancer Risk by Occupation. American Journal of Industrial Medicine. 1996;30(4):430–37. [PubMed: 8892548]
  23. Coogan P. F., Rosenburg L., Shapiro S., Hoffmann M. Lactation and Breast Carcinoma in a South African Population. Cancer. 1999;86:982–89. [PubMed: 10491524]
  24. Cook P. J., Burkitt D. P. Cancer in Africa. British Medical Bulletin. 1971;27:14–20. [PubMed: 5100946]
  25. Cook-Mozaffari P., Newton R., Beral V., Burkitt D. P. The Geographical Distribution of Kaposi Sarcoma and of Lymphomas in Africa before the AIDS Epidemic. British Journal of Cancer. 1998;78:1521–28. [PMC free article: PMC2063225] [PubMed: 9836488]
  26. de Thé G., Geser A., Day N. E., Tukei P. M., Williams E. H., Beri D. P., Smith P. G. et al. Epidemiological Evidence for Causal Relationship between Epstein Barr Virus and Burkitt's Lymphoma from Ugandan Prospective Study. Nature. 1978;274:756–61. [PubMed: 210392]
  27. Dorn, H. F., and S. J. Cutler. 1959. Morbidity from Cancer in the United States: Parts I and II. Public Health Monograph 56. Washington, DC: U.S. Department of Health, Education and Welfare.
  28. Dorrington, R., D. Bourne, D. Bradshaw, R. Laubscher, and I. M. Timaeus. 2001. The Impact of HIV/Aids on Adult Mortality. MRC Technical Report. Cape Town: MRC. http://www​
  29. Dukers N. H., Rezza G. Human Herpesvirus 8 Epidemiology: What We Do and Do Not Know. AIDS. 2003;17:1717–30. [PubMed: 12891058]
  30. Echimane A. K., Ahnoux A. A., Adoubi I., Hien S., M'Bra K., D'Horpock A., Diomande M., Anongba D., Mensah-Adoh I., Parkin D. M. Cancer Incidence in Abidjan, Ivory Coast: First Results from the Cancer Registry, 1995–1997. Cancer. 2000;89(3):653–63. [PubMed: 10931466]
  31. Ferlay, J., F. Bray, P. Pisani, and D. M. Parkin. 2004. "GLOBOCAN 2002: Cancer Incidence, Mortality and Prevalence Worldwide." Version 2.0, IARC CancerBase 5. Lyons: IARC Press.
  32. Flegg Mitchell H. Sociological Aspects of Cancer Rate Surveys in Africa. Journal of the National Cancer Institute Monographs. 1966;25:151–70. [PubMed: 6033050]
  33. Geser A., Brubaker G., Draper C. C. Effect of a Malaria Suppression Program on the Incidence of African Burkitt's Lymphoma. American Journal of Epidemiology. 1989;129:740–52. [PubMed: 2923122]
  34. Geser A., de Thé G., Lenoir G., Day N. E., Williams E. H. Final Case Reporting from the Ugandan Prospective Study of the Relationship between EBV and Burkitt's Lymphoma. International Journal of Cancer. 1982;29:397–400. [PubMed: 6282763]
  35. Grulich A. E., Beral V., Swerdlow A. J. Kaposi Sarcoma in England and Wales before the AIDS Epidemic. British Journal of Cancer. 1992;66:1135–37. [PMC free article: PMC1978016] [PubMed: 1457354]
  36. Harington J. S., Bradshaw E. M., McGlashan N. D. Changes in Primary Liver and Oesophageal Cancer Rates among Black Goldminers, 1964–1981. South African Medical Journal. 1983;64:650. [PubMed: 6623262]
  37. Hayes R. B., Pottern L. M., Strickler H., Rabkin C., Pope V., Swanson G. M., Greenberg R. S. et al. Sexual Behaviour, STDs and Risks for Prostate Cancer. British Journal of Cancer. 2000;82(3):718–25. [PMC free article: PMC2363322] [PubMed: 10682688]
  38. Henderson B. E., Ross R., Bernstein L. Estrogens as a Cause of Human Cancer: The Richard and Hinda Rosenthal Foundation Award Lecture. Cancer Research. 1988;48:246–53. [PubMed: 2825969]
  39. Hunter D. J., Spiegelman D., Adami H.-O., Beeson L., van den Brandt P. A., Folsom A. R., Fraser G. E. et al. Cohort Studies of Fat Intake and the Risk of Breast Cancer—A Pooled Analysis. New England Journal of Medicine. 1996;334:356–61. [PubMed: 8538706]
  40. IARC (International Agency for Research on Cancer). 1986. Tobacco Smoking. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, vol. 38. Lyons: IARC Press.
  41. ———. 1988. Alcohol Drinking. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, vol. 44. Lyons: IARC Press. [PubMed: 3236394]
  42. ———. 1993. Some Naturally Occurring Substances: Food Items and Constituents, Heterocyclic Aromatic Amines and Mycotoxins. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, vol. 56. Lyons: IARC Press.
  43. ———. 1994. Schistosomes, Liver Flukes and Helicobacter pylori. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, vol. 61. Lyons: IARC Press. [PubMed: 7715068]
  44. ———. 1996. Human Immunodeficiency Viruses and Human T-Cell Lymphotrophic Viruses. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, vol. 67. Lyons: IARC Press. [PubMed: 9190379]
  45. ———. 1997. Epstein-Barr Virus and Kaposi Sarcoma Herpesvirus/Human Herpesvirus 8. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, vol. 70. Lyons: IARC Press. [PubMed: 9705682]
  46. ———. 1999. Hormonal Contraception and Post-menopausal Hormonal Therapy. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, vol. 72. Lyons: IARC Press.
  47. ———. 2002. Some Traditional Herbal Medicines, Some Mycotoxins, Naphthalene and Styrene. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, vol. 82. Lyons: IARC Press. [PubMed: 12687954]
  48. ———. 2004. Tobacco Smoke and Involuntary Smoking. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, vol. 83. Lyons: IARC Press. [PubMed: 15285078]
  49. International Collaboration on HIV Cancer. Review: Breastfeeding Is Associated with Reduced Risk of Breast Cancer. Lancet. 2002;20:187–95.
  50. Jaffe, E. S., N. L. Harris, H. Stein, and J. W. Vardiman, eds. 2001. WHO Classification of Tumours: Pathology and Genetics of Tumours of the Haematopoietic and Lymphoid Tissues. Lyons: IARC Press.
  51. Jaskiewicz K., Lowrens H. D., Woodroof C. W., van Wyk M. J., Price S. K. The Association of Campylobacter pylori with Mucosal Pathological Changes in a Population at Risk of Gastric Cancer. South African Medical Journal. 1989;75:417–19. [PubMed: 2470157]
  52. Key, T. 1995. "Risk Factors for Prostate Cancer." In Preventing Prostate Cancer. Screening versus Chemoprevention, ed. R. T. D. Oliver, A. Belldegrun, and P. F. M. Wrigley. Cancer Surveys, vol. 23. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press.
  53. Kidd M., Lastovica A. J., Atherton J. C., Louw J. A. Heterogeneity in the Helicobacter Pylori VacA and CagA Genes: Association with Gastroduodenal Disease in South Africa? Gut. 1999;45:499–502. [PMC free article: PMC1727692] [PubMed: 10486355]
  54. Kirk G. D., Lesi O. A., Mendy M., Akano A. O., Sam O., Goedert J. J., Hainaut P., Hall A., Whittle H., Montesano R. The Gambia Liver Cancer Study. Infection with Hepatitis B and C: The Risk of Hepatocellular Carcinoma in West Africa. Hepatology. 2004;39:211–19. [PubMed: 14752840]
  55. Kogevinas, M., N. Pearce, M. Susser, and P. Boffetta, eds. 1997. Social Inequalities and Cancer. IARC Scientific Publications 138. Lyons: IARC Press.
  56. Kolonel L. N. Nutrition and Prostate Cancer. Cancer Causes and Control. 1996;7:83–94. [PubMed: 8850437]
  57. Koulibaly M., Kabba I. S., Cisse A., Diallo S. B., Diallo M. B., Keita N., Camara N. D., Diallo M. S., Sylla B. S., Parkin D. M. Cancer Incidence in Conakry, Guinea: First Results from the Cancer Registry 1992–1995. International Journal of Cancer. 1997;70(1):39–45. [PubMed: 8985088]
  58. Labadarios D., Walker A. R., Blaauw R., Walker B. F. Traditional Diets and Meal Patterns in South Africa. World Review of Nutrition and Diet. 1996;79:70–108. [PubMed: 9111811]
  59. Levin C. V., El-Gueddari B., Meghzifene A. Radiation Therapy in Africa: Distribution and Equipment. Radiotherapy Oncology. 1999;52(1):79–84. [PubMed: 10577690]
  60. Louw J. A., Kidd M. S. G., Kummer A. F., Taylor K., Kotze U., Hanslo D. The Relationship between Helicobacter pylori Infection, the Virulence Genotypes of the Infecting Strain and Gastric Cancer in the African Setting. Helicobacter. 2001;6:268–73. [PubMed: 11843958]
  61. Madhava V., Burgess C., Drucker E. Epidemiology of Chronic Hepatitis C Virus Infection in Sub-Saharan Africa. Lancet Infectious Disease. 2002;2:293–302. [PubMed: 12062995]
  62. Mandelblatt J., Kanetsky P., Eggert L., Gold K. Is HIV Infection a Cofactor for Cervical Squamous Cell Neoplasia? Cancer Epidemiology Biomarkers and Prevention. 1999;8:97–106. [PubMed: 9950246]
  63. Mandishona E., MacPhail A. P., Gordeuk V. R., Kedda M. A., Paterson A. C., Rouault T. A., Kew M. C. Dietary Iron Overload as a Risk Factor for Hepatocellular Carcinoma in Black Africans. Hepatology. 1998;27:1563–66. [PubMed: 9620327]
  64. Manning E. B., Mann J. I., Sophangisa E., Truswell A. S. Dietary Patterns in Urbanised Blacks. South African Medical Journal. 1971;48:488–98. [PubMed: 4821952]
  65. Mathers C. D., Fat D. M., Inoue M., Rao C., Lopez A. D. Counting the Dead and What They Died From: An Assessment of the Global Status of Cause of Death Data. Bulletin of the World Health Organization. 2005;83:171–77. [PMC free article: PMC2624200] [PubMed: 15798840]
  66. Mbulaiteye S. M., Katabira E. T., Wabinga H., Parkin D. M., Virgo P., Ochai R., Workneh M., Coutinho A., Engels E. A. Spectrum of Cancers among HIV-Infected Persons in Africa: The Uganda AIDS-Cancer Registry Match Study. International Journal of Cancer. Forthcoming. [PubMed: 16106415]
  67. McFarlane G., Forman D., Sitas F., Lachlan G. A Minimum Estimate for the Incidence of Gastric Cancer in Eastern Kenya. British Journal of Cancer. 2001;85(9):1322–25. [PMC free article: PMC2375245] [PubMed: 11720468]
  68. Miller, A. B. 1992. Cervical Cancer Screening Programmes. Managerial Guidelines. Geneva: WHO.
  69. Motala A. A. Diabetes Trends in Africa. Diabetes Metabolism Research Reviews. 2002;18(Suppl. 3):S14–20. [PubMed: 12324980]
  70. Muir, C., J. Waterhouse, T. Mack, J. Powell, S. Whelan, M. Smans, and F. Casset. 1987. Cancer Incidence in Five Continents. Vol. 5. IARC Scientific Publication 88. Lyons: IARC Press.
  71. Muir-Grieve, J. "South Africa, Cape Province." 1960. In Cancer Incidence in Five Continents, vol. 2, ed. R. Doll, C. Muir, and J. Waterhouse, 98–109. Berlin: Springer Verlag.
  72. Mzileni O., Sitas F., Steyn K., Carrara H., Bekker P. Lung Cancer, Tobacco and Environmental Factors in the African Population of the Northern Province, South Africa. Tobacco Control. 1999;8:398–401. [PMC free article: PMC1759754] [PubMed: 10629246]
  73. Newton R., Grulich A., Beral V., Sindikubwabo B., Ngilimana P.-J., Nganyira A., Parkin D. M. Cancer and HIV Infection in Rwanda. Lancet. 1995;345(8961):1378–79. [PubMed: 7752795]
  74. Newton R., Ngilimana P.-J., Grulich A., Beral V., Sindikubwabo B., Nganyira A., Parkin D. M. Cancer in Rwanda. International Journal of Cancer. 1996;66:75–81. [PubMed: 8608971]
  75. Newton, R., F. Sitas, M. Dedicoat, and J. L. Ziegler. 2002. "HIV Infection and Cancer." In AIDS in Africa, 2nd ed., ed. M. Essex, S. Mboup, P. J. Kanki, R. G. Marlink, and S. D. Tlou. New York: Kluwer Academic.
  76. Newton R., Ziegler J., Beral V. the Uganda Kaposi Sarcoma Study Group. A Case-Control Study of Human Immunodeficiency Virus Infection and Cancer in Adults and Children Residing in Kampala, Uganda. International Journal of Cancer. 2001;92:622–27. [PubMed: 11340563]
  77. O'Conor G. T. Persistent Immunologic Stimulation as a Factor in Oncogenesis with Special Reference to Burkitt's Tumour. Annual Journal of Medicine. 1970;48:279–85. [PubMed: 4190958]
  78. Oettlé A. G. Geographical and Racial Differences in the Frequency of Kaposi Sarcoma as Evidence of Environmental or Genetic Causes. Acta Unio Internationalis Contra Cancrum. 1962;18:330–63. [PubMed: 14481196]
  79. ———1964. Cancer in Africa Especially in Region South of the Sahara Journal of the National Cancer Institute 33383–439. [PubMed: 14207854]
  80. Oettlé A. G., Higginson J. Age Specific Cancer Incidence Rates in the South African Bantu: Johannesburg 1953–1955. South African Journal of Medical Science. 1966;31:21–41. [PubMed: 5953936]
  81. Pacella-Norman R., Urban M. I., Sitas F., Carrara H., Sur R., Hale M., Ruff P. et al. Risk Factors for Oesophageal, Lung, Oral and Laryngeal Cancers in Black South Africans. British Journal of Cancer. 2002;86(11):1751–56. [PMC free article: PMC2375408] [PubMed: 12087462]
  82. Pagano J. S., Jimenez G., Sung N. S., Raab-Traub N., Lin J. C. Epstein-Barr Viral Latency and Cell Immortalization as Targets for Antisense Oligomers. Annals of the New York Academy of Sciences. 1992;660:107–16. [PubMed: 1340114]
  83. Parkin, D. M., J. Ferlay, M. Hamdi-Cherif, F. Sitas, J. O. Thomas, H. Wabinga, and S. L. Whelan. 2003. Cancer in Africa—Epidemiology and Prevention. IARC Scientific Publications 153. Lyons: IARC Press.
  84. Parkin D. M., Pisani P., Lopez A. D., Masuyer E. At Least One in Seven Cases of Cancer Is Caused by Smoking. Global Estimates for 1985. International Journal of Cancer. 1994;59:494–504. [PubMed: 7960219]
  85. Parkin D. M., Sasco A. J. Lung Cancer: Worldwide Variation in Occurrence and Proportion Attributable to Tobacco Use. Lung Cancer. 1993;9:1–16.
  86. Parkin D. M., Wabinga H. R., Nambooze S., Wabwire-Mangen F. AIDS Related Cancers in Africa. Maturation of the Epidemic in Uganda. AIDS. 1999;13:2563–70. [PubMed: 10630526]
  87. Peto, R., A. D. Lopez, J. Boreham, M. Thun, and C. Heath. 2004. Mortality from Smoking in Developed Countries 1950–2000. Oxford: Oxford University Press.
  88. Pisani P., Parkin D. M., Munoz N., Ferlay J. Cancer and Infection: Estimates of the Attributable Fraction in 1990. Cancer Epidemiology, Biomarkers Prevention. 1997;6:387–400. [PubMed: 9184771]
  89. Prates M. D., Torres F. O. A Cancer Survey in Lorenco Marques, Portuguese East Africa. Journal of the National Cancer Institute. 1965;35:729–57. [PubMed: 5892211]
  90. Prentice R. L., Sheppard L. Dietary Fat and Cancer: Consistency of Epidemiologic Data and Disease Prevention that May Follow from a Practical Reduction in Fat Consumption. Cancer Causes and Control. 1990;1:81–97. [PubMed: 2102280]
  91. Rabkin C. S., Biggar R. J., Horm J. W. Increasing Incidence of Cancers Associated with the Human Immunodeficiency Virus Epidemic. International Journal of Cancer. 1991;47:692–96. [PubMed: 2004849]
  92. Reeves G. Breast Cancer and Oral Contraceptives—The Evidence So Far. Cancer Causes and Control. 1996;7:495–96. [PubMed: 8877045]
  93. Remick S. C. Acquired Immunodeficiency Syndrome-Related Non-Hodgkin Lymphoma. Cancer Control. 1995;2:97–103. [PubMed: 10887018]
  94. Reza A., Mercy J. A., Krug E. Epidemiology of Violent Deaths in the World. Injury and Prevention. 2001;7:104–11. [PMC free article: PMC1730718] [PubMed: 11428556]
  95. Robertson M. A. Clinical Observations on Cancer Patterns at the Non-White Hospital Baragwanath, Johannesburg, 1948–1964. South African Medical Journal. 1969;26:915–31. [PubMed: 4309403]
  96. Rosenberg L., Kelly J. P., Shapiro S., Hoffman M., Cooper D. Risk Factors for Breast Cancer in South African Women. South African Medical Journal. 2002;92:447–48. [PubMed: 12146129]
  97. Ross R. K., Pike M. C., Coetzee G. A., Reichardt J. K., Yu M. C., Feigelson H., Stanczyk F. Z., Kolonel L. N., Henderson B. E. Androgen Metabolism and Prostate Cancer: Establishing a Model of Genetic Susceptibility. Cancer Research. 1998;58:4497–4504. [PubMed: 9788589]
  98. Sammon A. M. A Case-Control Study of Diet and Social Factors in Cancer of the Oesophagus in Transkei. Cancer. 1992;69:860–65. [PubMed: 1735077]
  99. Sasco A., Lowels A. B., Pasker de Jong P. Epidemiology of Male Breast Cancer. A Meta-Analysis of Published Cases-Control Studies and Discussion of Selected Etiological Factors. International Journal of Cancer. 1993;53:538–49. [PubMed: 8436428]
  100. Sathar M. A., Simjee A. E., Wittenberg D. F., Mayat A. M. Seroprevalence of Helicobacter pylori Infection in Natal/KwaZulu, South Africa. European Journal of Gastroenterology and Hepatology. 1994;6:37–41.
  101. Schonland M., Bradshaw E. Cancer in the Natal African and Indian, 1964–1966. International Journal of Cancer. 1968;3:304–16. [PubMed: 5649163]
  102. Schultz T. F., Boshoff C. H., Weiss R. A. HIV Infection and Neoplasia. Lancet. 1996;348:587–91. [PubMed: 8774574]
  103. Seedat Y. K. Hypertension in Developing Nations in Sub-Saharan Africa. Journal of Human Hypertension. 2000;14:739–47. [PubMed: 11095164]
  104. Shapiro S., Rosenberg L., Hoffman M., Truter H., Cooper D., Rao S., Dent D. et al. Risk of Breast Cancer in Relation to the Use of Injectable Progestogen Contraceptives and Combined Estrogen/Progestogen Contraceptives. American Journal of Epidemiology. 2000;151:396–403. Erratum in American Journal of Epidemiology 151: 1134. [PubMed: 10695598]
  105. Shibata A., Whittemore A. S. Genetic Predisposition to Prostate Cancer: Possible Explanations for Ethnic Differences in Risk. Prostate. 1997;32:65–72. [PubMed: 9207959]
  106. Sitas F., Bezwoda W. R., Levin V., Ruff P., Kew M. C., Hale M. J., Carrara H. et al. Association between Human Immunodeficiency Virus Type 1 Infection and Cancer in the Black Population of Johannesburg and Soweto, South Africa. British Journal of Cancer. 1997;75:1704–7. [PMC free article: PMC2223539] [PubMed: 9184191]
  107. Sitas F., Carrara H., Beral V., Newton R., Reeves G., Bull D., Jentsch U. et al. The Seroepidemiology of HHV-8/KSHV in a Large Population of Black Cancer Patients in South Africa. New England Journal of Medicine. 1999;340:1863–71. [PubMed: 10369849]
  108. Sitas, F., J. Madhoo, and J. Wessie. 1998. "Incidence of Histologically Diagnosed Cancer in South Africa 1993–1995." National Cancer Registry, South African Institute for Medical Research, Johannesburg.
  109. Sitas F., Pacella-Norman R., Carrara H., Patel M., Ruff P., Sur R., Jentsch U. et al. The Spectrum of HIV-1 Related Cancers in South Africa. International Journal of Cancer. 2000;88:489–92. [PubMed: 11054682]
  110. Sitas F., Urban M., Bradshaw D., Kielkowski D., Bah S., Peto R. Tobacco Attributable Deaths in South Africa. Tobacco Control. 2004;13:396–99. [PMC free article: PMC1747967] [PubMed: 15564624]
  111. Skinner, M. E. G., D. M. Parkin, A. P. Vizcaino, and A. Ndhlovu. 1993. Cancer in the African Population of Bulawayo, Zimbabwe, 1963–1977. IARC Technical Report 15. Lyons: IARC Press.
  112. Somdyala N. I., Marasas W. F., Venter F. S., Vismer H. F., Gelderblom W. C., Swanevelder S. A. Cancer Patterns in Four Districts of the Transkei Region—1991–1995. South African Medical Journal. 2003;93(2):144–48. [PubMed: 12640888]
  113. Ssali J. C., Gakwaya A., Katangole-Mbidde E. Risk Factors for Breast Cancer in Ugandan Women: A Case Control Study. Eastern and Central African Journal of Surgery. 1995;1:9–13.
  114. ter Meulen J., Eberhardt H. C., Luande J., Mgaya H. N., Chang-Claude J., Mtiro H., Mhina M. et al. Human Papillomavirus (HPV) Infection, HIV Infection and Cervical Cancer in Tanzania, East Africa. International Journal of Cancer. 1992;51:515–21. [PubMed: 1318265]
  115. Timaeus, I. M. 1999. "Mortality in Sub-Saharan Africa." In Health and Mortality: Issues of Global Concern, ed. J. Chamie and R. L. Cliquet, 108–31. New York: United Nations Population Division.
  116. Turner P. C., Sylla A., Gong Y. Y., Diallo M. S., Sutcliffe A. E., Hall A. J., Wild C. P. Reduction in Exposure to Carcinogenic Aflatoxins by Postharvest Intervention Measures in West Africa: A Community-Based Intervention Study. Lancet. 2005;365:1950–56. [PubMed: 15936422]
  117. University of Zimbabwe/JHPIEGO Cervical Cancer Project. Visual Inspection with Acetic Acid for Cervical Cancer Screening: Test Qualities in a Primary-Care Setting. Lancet. 1999;353(9156):869–73. [PubMed: 10093978]
  118. Van Rensburg S. J. Epidemiologic and Dietary Evidence for a Specific Nutritional Predisposition to Esophageal Cancer. Journal of the National Cancer Institute. 1981;67:243–51. [PubMed: 6943364]
  119. Wabinga H. R., Parkin D. M., Wabwire-Mangen F., Mugerwa J. W. Cancer in Kampala, Uganda, in 1989–91: Changes in Incidence in the Era of AIDS. International Journal of Cancer. 1993;54:26–36. [PubMed: 8478145]
  120. Wabinga H. R., Parkin D. M., Wabwire-Mangen F., Nambooze S. Trends in Cancer Incidence in Kyadondo County, Uganda, 1960–1997. British Journal of Cancer. 2000;82:1585–92. [PMC free article: PMC2363394] [PubMed: 10789729]
  121. Walker A. R. P., Walker B. F., Funani S., Walker A. J. Characteristics of Black Women with Breast Cancer in Soweto, South Africa. Cancer Journal. 1989;2:316–19.
  122. Walker A. R. P., Walker B. F., Tsotetsi N. G., Sebitso C., Siwedi D., Walker A. J. Case-Control Study of Prostate Cancer in Black Patients in Soweto, South Africa. British Journal of Cancer. 1992;65:438–41. [PMC free article: PMC1977613] [PubMed: 1558801]
  123. Walker R. W., McLarty D. G., Kitange H. M., Whiting D., Masuki G., Mtasiwa D. M., Machibya H., Unwin N., Alberti K. G. Stroke Mortality in Urban and Rural Tanzania. Adult Morbidity and Mortality Project. Lancet. 2000;355:1684–87. [PubMed: 10905244]
  124. Whittle H. C., Brown J., Marsh K., Blackman M., Jobe O., Shenton F. The Effects of Plasmodium falciparum Malaria on Immune Control of B Lymphocytes in Gambian Children. Clinical and Experimental Immunology. 1990;80:213–18. [PMC free article: PMC1535277] [PubMed: 1972671]
  125. WHO (World Health Organization). 1997. Tobacco or Health: A Global Status Report. Geneva: WHO.
  126. ———. 2004. The World Health Report 2004—Changing History. Geneva: WHO.
  127. Wild C. P., Hall A. J. Primary Prevention of Hepatocellular Carcinoma in Developing Countries. Mutation Research. 2000;462:381–93. [PubMed: 10767647]
  128. Williams E. H., Smith P. G., Day N. E., Geser A., Ellis J., Tukei P. Space-Time Clustering of Burkitt's Lymphoma in West Nile District of Uganda: 1961–1975. British Journal of Cancer. 1978;37:805–9.
  129. Wright D. H. Lympho-Reticular Neoplasms. Recent Results in Cancer Research. 1973;41:270–91. [PubMed: 4612655]