Figure 9.8. Peptide Hydrolysis by Chymotrypsin.

Figure 9.8Peptide Hydrolysis by Chymotrypsin

The mechanism of peptide hydrolysis illustrates the principles of covalent and acid-base catalysis. The dashed green lines indicate favorable interactions between the negatively charged aspartate residue and the positively charged histidine residue, which make the histidine residue a more powerful base.

From: Section 9.1, Proteases: Facilitating a Difficult Reaction

Cover of Biochemistry
Biochemistry. 5th edition.
Berg JM, Tymoczko JL, Stryer L.
New York: W H Freeman; 2002.
Copyright © 2002, W. H. Freeman and Company.

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