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Figure 13.28. Inactivation of the Potassium Channel.

Figure 13.28Inactivation of the Potassium Channel

The amino-terminal region of the potassium chain is critical for inactivation. (A) The wild-type Shaker potassium channel displays rapid inactivation after opening. (B) A mutant channel lacking residues 6 through 46 does not inactivate. (C) Inactivation can be restored by adding a peptide consisting of residues 1 through 20 at a concentration of 100 μM. [After W. N. Zagotta, T. Hoshi, and R. W. Aldrich. Science 250(1990):568.]

From: Section 13.5, Specific Channels Can Rapidly Transport Ions Across Membranes

Cover of Biochemistry
Biochemistry. 5th edition.
Berg JM, Tymoczko JL, Stryer L.
New York: W H Freeman; 2002.
Copyright © 2002, W. H. Freeman and Company.

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