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Figure 31.27. Estrogen Receptor-Tamoxifen Complex.

Figure 31.27Estrogen Receptor-Tamoxifen Complex

Figure 31.27. Estrogen Receptor-Tamoxifen Complex. Tamoxifen binds in the pocket normally occupied by estrogen. However, part of the tamoxifen structure extends from this pocket, and so helix 12 cannot pack in its usual position. Instead, this helix blocks the coactivator-binding site.

From: Section 31.3, Transcriptional Activation and Repression Are Mediated by Protein-Protein Interactions

Cover of Biochemistry
Biochemistry. 5th edition.
Berg JM, Tymoczko JL, Stryer L.
New York: W H Freeman; 2002.
Copyright © 2002, W. H. Freeman and Company.

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