Figure 23.31. Structure of One Subunit of Phenylalanine Hydroxylase.

Figure 23.31Structure of One Subunit of Phenylalanine Hydroxylase

Mutations in the genes encoding this enzyme cause phenylketonuria. More than 200 point mutations have been identified in these genes. The positions of five mutations affecting the active site (blue), the biopterin-binding site (red), and other regions of the protein (purple) are indicated as colored spheres.

From: Section 23.5, Carbon Atoms of Degraded Amino Acids Emerge as Major Metabolic Intermediates

Cover of Biochemistry
Biochemistry. 5th edition.
Berg JM, Tymoczko JL, Stryer L.
New York: W H Freeman; 2002.
Copyright © 2002, W. H. Freeman and Company.

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