Figure 22.19. Formation of Ketone Bodies.

Figure 22.19Formation of Ketone Bodies

The Ketone bodies-acetoacetate, d-3-hydroxybutyrate, and acetone from acetyl CoA—are formed primarily in the liver. Enzymes catalyzing these reactions are (1) 3-ketothiolase, (2) hydroxymethylglutaryl CoA synthase, (3) hydroxymethylglutaryl CoA cleavage enzyme, and (4) d-3-hydroxybutyrate dehydrogenase. Acetoacetate spontaneously decarboxylates to form acetone.

From: Section 22.3, Certain Fatty Acids Require Additional Steps for Degradation

Cover of Biochemistry
Biochemistry. 5th edition.
Berg JM, Tymoczko JL, Stryer L.
New York: W H Freeman; 2002.
Copyright © 2002, W. H. Freeman and Company.

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