Figure 4. b.

Figure 4

b. Schematic of the PI3P-binding site of the FYVE domain. The phosphoinositide is intentionally drawn as an oversimplified achiral molecule to emphasize the pseudo-twofold relationship between PI3P and PI5P. Equivalent residues from the Vps27p (black) and EEA1 (gray) FYVE domains are shown. Trp170/1348 does not bind PI3P, but helps to buttress His191/1372 and the ligand-binding site.

From: Signaling and Subcellular Targeting by Membrane-Binding Domains

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