Table 3Transmembrane cell surface mammalian and yeast proteins that are subject to ubiquitination

Transmembrane proteinCharacteristics (see below)References
TCRb,d,i(Cenciarelli et al 1992, 1996, Hou et al 1994)
FcεRIb,j(Paolini & Kinet 1993)
PDGFRβb,d(Mori et al 1992, 1993)
c-kitb,d,i(Miyazawa et al 1994, AM Weissman unpublished data)
GHRb,f(Strous et al 1996, 1997)
EGFRb,d(Galcheva-Gargova et al 1995)
c-Metb,g(Jeffers et al 1997)
Fibroblast growth factor receptorb(Mori et al 1995a)
Colony stimulating factor 1 receptorb(Mori et al 1995a)
Insulin receptora,g,k(Sepp-Lorenzino et al 1995)
Insulin-like growth factor receptora,g,k(Sepp-Lorenzino et al 1995)
p185c-erbB-2g,k(Mimnaugh et al 1996)
Mel-14l(Siegelman et al 1986, St. John et al 1986)
ErbB-4m(Vecchi & Carpenter 1997)
Ste2pb,e,f,h(Hicke & Riezman 1996, Hicke et al 1998, Terrell et al 1998)
Ste6pf(Kolling & Hollenberg 1994, Kolling & Losko 1997)
Pdr5pf(Egner & Kuchler 1996)
Fur4pc,f,h(Galan & Haguenauer-Tsapis 1997, Galan et al 1996, Hein et al 1995, Marchal et al 1998)
Ste3pb,f(Roth & Davis 1996)
Gap1pf,h(Hein et al 1995, Springael & André 1998)
a

Ubiquitination not directly demonstrated;

b

ligand-dependent ubiquitination;

c

ubiquitin linkage analyzed;

d

associated with tyrosine phosphorylation;

e

associated with serine/threonine phosphorylation;

f

ubiquitination associated with endocytosis;

g

ubiquitination associated with proteasomal degradation;

h

Rsp5 implicated;

i

degraded primarily in lysosomes; ubiquitination not directly implicated;

j

reversible ubiquitination;

k

in response to benzoquinone ansamycins (herbimycin A, geldenamycin);

l

luminal ubiquitination, significance unclear;

m

ubiquitin-proteasome-mediated degradation of an intracellular cleavage product.

From: Ubiquitin and the Control of Protein Fate in the Secretory and Endocytic Pathways

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