Figure 16-34. Mismatch repair in humans.

Figure 16-34

Mismatch repair in humans. (1) Mispairs and misaligned bases arise in the course of replication. (2) The GT-binding protein (GTBP) and the human MutS homolog (hMSH2) recognize the incorrect matches. (3) Two additional proteins, hPMS2 and hMLH1, are recruited and form a larger repair complex. (4) The mismatch is repaired after removal, DNA synthesis, and ligation. (From P. Karran, Science 268, 1995, 1857.)

From: Biological repair mechanisms

Cover of An Introduction to Genetic Analysis
An Introduction to Genetic Analysis. 7th edition.
Griffiths AJF, Miller JH, Suzuki DT, et al.
New York: W. H. Freeman; 2000.
Copyright © 2000, W. H. Freeman and Company.

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