Figure 16-31. The GO system.

Figure 16-31

The GO system. (a) 8-OxodG lesions are removed by the MutM protein, leaving an AP site that is repaired by endonucleases and repair synthesis. (b) However, when replicating polymerases are allowed to operate across from the lesion, they usually add an A residue. This mispair would result in the GC → TA change, but the MutY protein removes the A, allowing repair of the resulting AP site. (c) When repair polymerases operate across from the 8-oxodG lesion, they preferentially restore a C across from the lesion, allowing the MutM protein another opportunity to remove the lesion.

From: Biological repair mechanisms

Cover of An Introduction to Genetic Analysis
An Introduction to Genetic Analysis. 7th edition.
Griffiths AJF, Miller JH, Suzuki DT, et al.
New York: W. H. Freeman; 2000.
Copyright © 2000, W. H. Freeman and Company.

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