Figure 16-17. Alkylation-induced specific mispairing.

Figure 16-17

Alkylation-induced specific mispairing. The alkylation (in this case, EMS-generated ethylation) of the O-6 position of guanine and the O-4 position of thymine can lead to direct mispairing with thymine and guanine, respectively, as shown here. In bacteria, where mutations have been analyzed in great detail, the principal mutations detected are GC → AT transitions, indicating that the O-6 alkylation of guanine is most relevant to mutagenesis.

From: Induced mutations

Cover of An Introduction to Genetic Analysis
An Introduction to Genetic Analysis. 7th edition.
Griffiths AJF, Miller JH, Suzuki DT, et al.
New York: W. H. Freeman; 2000.
Copyright © 2000, W. H. Freeman and Company.

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