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Cover of An Introduction to Genetic Analysis

An Introduction to Genetic Analysis, 7th edition

, , , , and .

Author Information

,1 ,2 ,1 ,3 and 3.

1 University of British Columbia
2 University of California, Los Angeles
3 Harvard University
New York: W. H. Freeman; .
ISBN-10: 0-7167-3520-2

Excerpt

True to its title, the theme of this book is genetic analysis. This theme emphasizes our belief that the best way to understand genetics is by learning how genetic inference is made. On almost every page, we recreate the landmark experiments in genetics and have the students analyze the data and draw conclusions as if they had done the research themselves. This proactive process teaches students how to think like scientists. The modes of inference and the techniques of analysis are the keys to future exploration.

Similarly, quantitative analysis is central to the book because many of the new ideas in genetics, from the original conception of the gene to such modern techniques as SSLP mapping, are based on quantitative analysis. The problems at the end of each chapter provide students with the opportunity to test their understanding in quantitative analyses that effectively simulate the act of doing genetics.

Contents

  • Preface
  • Chapter 1. Genetics and the Organism
    • Introduction
    • Genes as determinants of the inherent properties of species
    • Genetic variation
    • Methodologies used in genetics
    • Genes, the environment, and the organism
    • Summary
    • Concept Map
    • Problems
  • Chapter 2. Patterns of Inheritance
    • Introduction
    • Mendel’s experiments
    • Using genetic ratios
    • Sex chromosomes and sex-linked inheritance
    • Human genetics
    • Summary
    • Concept Map
    • Chapter Integration Problem
    • Solved Problems
    • Problems
  • Chapter 3. Chromosomal Basis of Heredity
    • Introduction
    • Historical development of the chromosome theory
    • Mendelian genetics in eukaryotic life cycles
    • Topography of the chromosome set
    • Three-dimensional structure of chromosomes
    • Sequence organization
    • Summary
    • Concept Map
    • Chapter Integration Problem
    • Solved Problems
    • Problems
  • Chapter 4. Gene Interaction
    • Introduction
    • From genes to phenotypes
    • A diagnostic test for alleles
    • Interactions between the alleles of one gene
    • Gene interaction and modified dihybrid ratios
    • Gene interaction in petal color of foxgloves
    • Gene interaction in coat color of mammals
    • Penetrance and expressivity
    • Chi-square test
    • Summary
    • Concept Map
    • Chapter Integration Problem
    • Solved Problems
    • Problems
  • Chapter 5. Basic Eukaryotic Chromosome Mapping
    • Introduction
    • The discovery of linkage
    • Recombination
    • Linkage symbolism
    • Linkage of genes on the X chromosome
    • Linkage maps
    • Three-point testcross
    • Interference
    • Calculating recombinant frequencies from selfed dihybrids
    • Examples of linkage maps
    • Chi-square test for linkage
    • Mapping with molecular markers
    • Linkage mapping by recombination in humans
    • Nature of crossing-over
    • Summary
    • Concept Map
    • Chapter Integration Problem
    • Solved Problems
    • Problems
  • Chapter 6. Specialized Eukaryotic Chromosome Mapping Techniques
    • Introduction
    • Accurate calculation of large map distances
    • Analysis of single meioses
    • Mapping genes by mitotic segregation and recombination
    • Mapping by in situ hybridization
    • Mapping human genes by using human–rodent somatic cell hybrids
    • Summary
    • Concept Map
    • Chapter Integration Problem
    • Solved Problems
    • Problems
  • Chapter 7. Gene Transfer in Bacteria and Their Viruses
    • Introduction
    • Working with microorganisms
    • Bacterial conjugation
    • Bacterial transformation
    • Bacteriophage genetics
    • Transduction
    • Chromosome mapping
    • Bacterial gene transfer in review
    • Summary
    • Concept Map
    • Chapter Integration Problem
    • Solved Problems
    • Problems
  • Chapter 8. The Structure and Replication of DNA
    • Introduction
    • DNA: The genetic material
    • Structure of DNA
    • Replication of DNA
    • Mechanism of DNA replication
    • Summary
    • Concept Map
    • Chapter Integration Problem
    • Solved Problems
    • Problems
  • Chapter 9. Genetics of DNA Function
    • Introduction
    • How genes work
    • Gene-protein relations
    • Genetic fine structure
    • Mutational sites
    • Complementation
    • Summary
    • Concept Map
    • Chapter Integration Problem
    • Solved Problems
    • Problems
  • Chapter 10. Molecular Biology of Gene Function
    • Introduction
    • Properties of RNA
    • Transcription
    • Transcription and RNA polymerase
    • Eukaryotic RNA
    • Translation
    • Genetic code
    • Protein synthesis
    • Universality of genetic information transfer
    • Functional division of labor in the gene set
    • Summary
    • Concept Map
    • Chapter Integration Problem
    • Solved Problems
    • Problems
  • Chapter 11. Regulation of Gene Transcription
    • Introduction
    • Basic control circuits
    • Discovery of the lac system: negative control
    • Catabolite repression of the lac operon: positive control
    • Positive and negative control
    • Dual positive and negative control: the arabinose operon
    • Metabolic pathways
    • Additional examples of control: attenuation
    • Lambda phage: a complex of operons
    • Transcription: an overview of gene regulation in eukaryotes
    • Regulation of transcription factors
    • Epigenetic inheritance
    • Summary
    • Concept Map
    • Chapter Integration Problem
    • Solved Problems
    • Problems
  • Chapter 12. Recombinant DNA Technology
    • Introduction
    • Making recombinant DNA
    • Cloning a specific gene
    • Using cloned DNA
    • Summary
    • Concept Map
    • Chapter Integration Problem
    • Solved Problem
    • Problems
  • Chapter 13. Applications of Recombinant DNA Technology
    • Introduction
    • In vitro mutagenesis
    • RFLP mapping
    • Reverse genetics
    • Expressing eukaryotic genes in bacteria
    • Recombinant DNA technology in eukaryotes
    • Gene therapy
    • Using recombinant DNA to detect disease alleles directly
    • Summary
    • Concept Map
    • Chapter Integration Problem
    • Solved Problems
    • Problems
  • Chapter 14. Genomics
    • Introduction
    • Genomics: an overview
    • Genome projects: practical considerations
    • Structural genomics
    • Functional genomics
    • Summary
    • Concept Map
    • Chapter Integration Problem
    • Solved Problems
    • Problems
  • Chapter 15. Gene Mutation
    • Introduction
    • How DNA changes affect phenotype
    • Somatic versus germinal mutation
    • Mutant types
    • Occurrence of mutations
    • Selective systems
    • Mutation induction
    • Mutation and cancer
    • Mutagens in genetic dissection
    • Mutation breeding
    • Summary
    • Concept Map
    • Chapter Integration Problem
    • Solved Problems
    • Problems
  • Chapter 16. Mechanisms of Gene Mutation
    • Introduction
    • Molecular basis of gene mutations
    • Spontaneous mutations
    • Induced mutations
    • Reversion analysis
    • Relation between mutagens and carcinogens
    • Biological repair mechanisms
    • Repair defects and human diseases
    • Summary
    • Concept Map
    • Chapter Integration Problem
    • Solved Problem
    • Problems
  • Chapter 17. Chromosome Mutation I: Changes in Chromosome Structure
    • Introduction
    • Origin of changes in chromosome structure
    • Deletions
    • Duplications
    • Inversions
    • Translocations
    • Diagnosis of rearrangements by tetrad analysis
    • Summary
    • Concept Map
    • Chapter Integration Problem
    • Solved Problems
    • Problems
  • Chapter 18. Chromosome Mutation II: Changes in Chromosome Number
    • Introduction
    • Aberrant euploidy
    • Aneuploidy
    • Mechanisms of gene imbalance
    • Chromosome mechanics in plant breeding
    • Summary
    • Concept Map
    • Chapter Integration Problem
    • Solved Problems
    • Problems
  • Chapter 19. Mechanisms of Recombination
    • Introduction
    • Breakage and reunion of DNA molecules
    • Chiasmata: the crossover points
    • Genetic results leading to recombination models
    • Holliday model
    • Enzymatic mechanism of recombination
    • Summary
    • Concept Map
    • Chapter Integration Problem
    • Solved Problems
    • Problems
  • Chapter 20. Transposable Genetic Elements
    • Introduction
    • Controlling elements in maize
    • Bacterial insertion sequences
    • Prokaryotic transposons
    • Mechanism of transposition in prokaryotes
    • Review of transposable elements in prokaryotes
    • Molecular nature of transposable elements in eukaryotes
    • Review of transposable elements in eukaryotes
    • Summary
    • Concept Map
    • Chapter Integration Problem
    • Solved Problem
    • Problems
  • Chapter 21. Extranuclear Genes
    • Introduction
    • Origin of extranuclear genes
    • Structure of organelle chromosomes
    • Organelle mutations
    • Inheritance of organelle genes and mutations
    • Recombination of extranuclear DNA
    • Cytoplasmic male sterility
    • Mitochondria and aging
    • Summary
    • Chapter Integration Problem
    • Solved Problems
    • Problems
  • Chapter 22. Cancer as a Genetic Disease
    • Introduction
    • Cancer and the control of cell number: an overview
    • Cell proliferation machinery
    • Machinery for programmed cell death
    • Controlling the cell-proliferation and death machinery
    • Cancer: the genetics of aberrant cell control
    • Cancer research in the genomic analysis era
    • Summary
    • Concept Map
    • Chapter Integration Problem
    • Solved Problems
    • Problems
  • Chapter 23. Developmental Genetics
    • Introduction
    • Central themes of developmental genetics
    • Gene regulation at levels other than transcription initiation: examples
    • Binary fate decisions: pathways of sex determination
    • Drosophila sex determination: every cell for itself
    • Sex determination in mammals: coordinated control by the endocrine system
    • Binary fate decisions: the germ line versus the soma
    • Forming complex pattern: establishing positional information
    • Forming complex pattern: utilizing positional information to establish cell fates
    • Additional aspects of pattern formation
    • The many parallels in vertebrate and insect pattern formation
    • Do the lessons of animal development apply to plants?
    • Summary
    • Concept Map
    • Chapter Integration Problem
    • Solved Problems
    • Problems
  • Chapter 24. Population Genetics
    • Introduction
    • Variation and its modulation
    • Effect of sexual reproduction on variation
    • Sources of variation
    • Selection
    • Balanced polymorphism
    • Artificial selection
    • Random events
    • Summary
    • Concept Map
    • Chapter Integration Problem
    • Solved Problems
    • Problems
  • Chapter 25. Quantitative Genetics
    • Introduction
    • Some basic statistical notions
    • Genotypes and phenotypic distribution
    • Norm of reaction and phenotypic distribution
    • Determining norms of reaction
    • Heritability of a trait
    • Quantifying heritability
    • Locating the genes
    • More on analyzing variance
    • Summary
    • Concept Map
    • Statistical Appendix
    • Chapter Integration Problem
    • Solved Problems
    • Problems
  • Chapter 26. Evolutionary Genetics
    • Introduction
    • A synthesis of forces: variation and divergence of populations
    • Multiple adaptive peaks
    • Heritability of variation
    • Observed variation within and between populations
    • Process of speciation
    • Origin of new genes
    • Rate of molecular evolution
    • Summary
    • Concept Map
    • Chapter Integration Problem
    • Solved Problems
    • Problems
  • Appendices
    • Genetic nomenclature
    • Further Readings
  • Glossary

By agreement with the publisher, this book is accessible by the search feature, but cannot be browsed.

Copyright © 2000, W. H. Freeman and Company.
Bookshelf ID: NBK21766

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