Figure 23-43. Experimental demonstration that agrin, which is associated with the basal lamina, promotes aggregation of acetylcholine receptors (AChRs).

Figure 23-43Experimental demonstration that agrin, which is associated with the basal lamina, promotes aggregation of acetylcholine receptors (AChRs)

Co-cultures of nerve and muscle cells were incubated in the presence or absence of agrin-specific antibody. Clustering of AChRs in the muscle-cell plasma membrane was determined by staining with fluorescent-labeled bungarotoxin, which binds specifically to acetylcholine receptors. Addition of anti-agrin antibodies prevented formation of AChR aggregates. [Adapted from N. E. Reist et al., 1992, Neuron 8:865.]

From: Section 23.7, Formation of Topographic Maps and Synapses

Cover of Molecular Cell Biology
Molecular Cell Biology. 4th edition.
Lodish H, Berk A, Zipursky SL, et al.
New York: W. H. Freeman; 2000.
Copyright © 2000, W. H. Freeman and Company.

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