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Figure 19-26. A general model for kinesin- and dynein-mediated transport in a typical cell.

Figure 19-26A general model for kinesin- and dynein-mediated transport in a typical cell

The array of microtubules, with their (+) ends pointing toward the cell periphery, radiates from an MTOC in the Golgi region. Kinesin-dependent anterograde transport conveys mitochondria (carried by KIF1B), lysosomes, and an assortment of membrane vesicles to the endoplasmic reticulum (ER) or cell periphery. Cytosolic dynein – dependent retrograde transport conveys elements of the ER, late endosomes, and lysosomes to the cell center. [Adapted from N. Hirokawa, 1998, Science 279:519.]

From: Section 19.3, Kinesin, Dynein, and Intracellular Transport

Cover of Molecular Cell Biology
Molecular Cell Biology. 4th edition.
Lodish H, Berk A, Zipursky SL, et al.
New York: W. H. Freeman; 2000.
Copyright © 2000, W. H. Freeman and Company.

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