Figure 22-23. Three-dimensional structure of the type III repeat of fibronectin that contains the RGD integrin-binding sequence.

Figure 22-23Three-dimensional structure of the type III repeat of fibronectin that contains the RGD integrin-binding sequence

The core of seven β strands in this domain has a structure similar to that of the “immunoglobulin fold,” a structural motif found in the light and heavy chains of antibody molecules. The side chains of the Arg78-Gly79-Asp80 sequence of the integrin- binding site are shown in yellow. [From A. L. Main et al., 1993, Cell 71:671; courtesy of A. Main and I. D. Campbell.]

From: Section 22.4, Noncollagen Components of the Extracellular Matrix

Cover of Molecular Cell Biology
Molecular Cell Biology. 4th edition.
Lodish H, Berk A, Zipursky SL, et al.
New York: W. H. Freeman; 2000.
Copyright © 2000, W. H. Freeman and Company.

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