Figure 9-44. Human mitochondrial DNA (mtDNA), which has been sequenced in its entirety.

Figure 9-44Human mitochondrial DNA (mtDNA), which has been sequenced in its entirety

Proteins and RNAs encoded by each of the two strands are shown separately. Transcription of the outer (H) strand occurs in the clockwise direction and of the inner (L) strand in the counterclockwise direction. The abbreviations for amino acids denote the corresponding tRNA genes. ND1, ND2, etc., denote genes encoding subunits of the NADH-CoQ reductase complex. The 207-bp gene encoding F0 ATPase subunit 8 overlaps, out of frame, with the N-terminal portion of the segment encoding F0 ATPase subunit 6. No mammalian mtDNA genes contain introns, although intervening DNA lies between some genes. [See D. A. Clayton, 1991, Ann. Rev. Cell Biol. 7:453.]

From: Section 9.7, Organelle DNAs

Cover of Molecular Cell Biology
Molecular Cell Biology. 4th edition.
Lodish H, Berk A, Zipursky SL, et al.
New York: W. H. Freeman; 2000.
Copyright © 2000, W. H. Freeman and Company.

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