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Lodish H, Berk A, Zipursky SL, et al. Molecular Cell Biology. 4th edition. New York: W. H. Freeman; 2000.

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Cover of Molecular Cell Biology

Molecular Cell Biology. 4th edition.

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Figure 24-20. TGFβ signaling.

Figure 24-20TGFβ signaling

TGFβ signals through heteromeric complexes of types I and II serine/threonine kinase receptors, leading to phosphorylation of either Smad2 or Smad3. A complex of one of these phosphorylated Smad proteins and Smad4 then translocates to the nucleus, where it binds to other transcription factors to activate transcription of a variety of genes. Expression of p15 causes cells to arrest in G1. See text for discussion. [See X. Hua et al., 1998, Genes & Develop. 12:3084; and C. H. Heldin et al., 1997, Nature 390:465.]

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