Figure 15-16. Schematic structural model for mammalian MDR1 protein. In this member of the ABC superfamily, the two transmembrane domains and two cytosolic ATP-binding domains are part of a single polypeptide.

Figure 15-16Schematic structural model for mammalian MDR1 protein. In this member of the ABC superfamily, the two transmembrane domains and two cytosolic ATP-binding domains are part of a single polypeptide

Each transmembrane domain contains six α helices. The two halves of this 1280-aa protein have similar amino acid sequences. A variety of lipid-soluble molecules that diffuse across the plasma membrane into the cell are transported outward by MDR1.

From: Section 15.5, Active Transport by ATP-Powered Pumps

Cover of Molecular Cell Biology
Molecular Cell Biology. 4th edition.
Lodish H, Berk A, Zipursky SL, et al.
New York: W. H. Freeman; 2000.
Copyright © 2000, W. H. Freeman and Company.

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