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Cover of Modern Genetic Analysis

Modern Genetic Analysis

, , , and .

Author Information

,1 ,2 ,3 and 2.

1 University of British Columbia
2 Harvard University
3 University of California, Los Angeles
New York: W. H. Freeman; .
ISBN-10: 0-7167-3118-5

Excerpt

Modern Genetic Analysis was written for instructors and students who need a textbook that supports the “DNA first” approach. This departure from the traditional historical unfolding of genetics has had some significant side effects—chief among them, a more streamlined presentation in which genetic principles stand in bolder relief.

Regardless of whether the presentation is traditional or modern, it is essential that students learn to think like geneticists. Thus, as in An Introduction to Genetic Analysis, the focus is on teaching students to analyze data and draw conclusions.

Contents

  • Preface
  • Supplements
  • Acknowledgments
  • Chapter 1. Genetics and the Organism
    • Introduction
    • Genetics and Human Affairs
    • Genetics and Biology
    • Genetics begins with Variation
    • Experimental Genetics
    • Summary
    • Concept Map
    • General Questions
  • Chapter 2. The Structure of Genes and Genomes
    • Introduction
    • The Nature of DNA
    • The Nature of Genes
    • The Nature of Genomes
    • The Nature of Eukaryotic Nuclear Chromosomes
    • Summary
    • Concept Map
    • Solved Problem
    • Solved Problem
    • Problems
  • Chapter 3. Gene Function
    • Introduction
    • Genes and RNA
    • Making Functional Transcripts
    • Protein Structure
    • Translation
    • Protein Function and Malfunction in Cells
    • Defective Proteins and Dominance And Recessiveness
    • Functional Division of Labor in the Gene Set
    • Summary
    • Concept Map
    • Solved Problem
    • Solved Problem
    • Problems
  • Chapter 4. The Inheritance of Genes
    • DNA Replication
    • Cell Division
    • Inheritance Patterns of Individual Genes
    • Human Pedigree Analysis
    • Inheritance of Organelle Genes
    • Summary
    • Concept Map
    • Solved Problem
    • Solved Problem
    • Problems
  • Chapter 5. Recombination of Genes
    • Introduction
    • Independent Assortment
    • Crossing-Over
    • Linkage Maps
    • Mitotic Crossing-Over
    • The Mechanism of Crossing-Over
    • Recombination within a Gene
    • Summary
    • Concept Map
    • Solved Problem
    • Solved Problem
    • Problems
  • Chapter 6. Gene Interaction
    • From Genes to Phenotypes
    • A Diagnostic Test for Alleles
    • Interactions Between the Alleles of One Gene
    • Gene Interaction Leads to Modified Dihybrid Ratios
    • Penetrance and Expressivity
    • Summary
    • Concept Map
    • Solved Problem
    • Solved Problem
    • Problems
  • Chapter 7. Gene Mutations
    • Introduction
    • The Molecular Basis of Mutation
    • Mutational Analysis
    • Summary
    • Concept Map
    • Solved Problem
    • Solved Problem
    • Solved Problem
    • Solved Problem
    • Problems
  • Chapter 8. Chromosome Mutations
    • Introduction
    • Changes in Chromosome Number
    • Chromosomal Rearrangements
    • The Overall Incidence of Human Chromosome Mutations
    • Evolution of the Genome
    • Summary
    • Concept Map
    • Solved Problem
    • Solved Problem
    • Problems
  • Chapter 9. The Genetics of Bacteria and Phages
    • Introduction
    • Working with Microorganisms
    • Bacterial Conjugation
    • Bacterial Transformation
    • Bacteriophage Genetics
    • Transduction
    • Bacterial Gene Transfer in Review
    • Summary
    • Concept Map
    • Solved Problem
    • Solved Problem
    • Solved Problem
    • Problems
  • Chapter 10. Recombinant DNA Technology
    • Introduction
    • Making Recombinant DNA
    • Cloning a Specific Gene
    • Using Cloned DNA
    • Summary
    • Concept Map
    • Solved Problem
    • Solved Problem
    • Solved Problem
    • Problems
  • Chapter 11. Applications of Recombinant DNA Technology
    • Introduction
    • In Vitro Mutagenesis
    • RFLP Mapping
    • Reverse Genetics
    • Expressing Eukaryotic Genes in Bacteria
    • Recombinant DNA Technology in Eukaryotes
    • Gene Therapy
    • Using Recombinant DNA to Detect Disease Alleles Directly
    • Summary
    • Concept Map
    • Solved Problem
    • Solved Problem
    • Problems
  • Chapter 12. Genomics
    • Introduction
    • Structural Genomics
    • Functional Genomics
    • Summary
    • Concept Map
    • Solved Problem
    • Solved Problem
    • Problems
  • Chapter 13. Transposable Genetic Elements
    • Introduction
    • Insertion Sequences
    • Transposons
    • Mechanism of Transposition
    • Rearrangements Mediated by Transposable Elements
    • Review of Transposable Elements in Prokaryotes
    • Ty Elements in Yeast
    • Transposable Elements in Drosophila
    • Retroviruses
    • Transposition through an RNA Intermediate
    • Controlling Elements in Maize
    • Review of Transposable Elements in Eukaryotes
    • Summary
    • Concept Map
    • Solved Problem
    • Problems
  • Chapter 14. Regulation of Gene Transcription
    • Introduction
    • The Logic of Prokaryotic Gene Regulation
    • The Basics of Prokaryotic Transcriptional Regulation
    • Regulation of the Lactose System
    • Dual Positive And Negative Control: the Arabinose Operon
    • Metabolic Pathways
    • Transcription: Gene Regulation in Eukaryotes— an Overview
    • Regulation of Transcription Factors
    • Epigenetic Inheritance
    • Summary
    • Concept Map
    • Solved Problems
    • Problems
  • Chapter 15. Regulation of Cell Number: Normal and Cancer Cells
    • Introduction
    • Cancer and the Control of Cell Number: an Overview
    • The Cell Proliferation Machinery
    • The Machinery or Programmed Cell Death
    • Controlling the Cell Proliferation and Death Machinery
    • Cancer: the Genetics of Aberrant Cell Control
    • Summary
    • Concept Map
    • Solved Problem
    • Problems
  • Chapter 16. The Genetic Basis of Development
    • Introduction
    • Central Themes of Developmental Genetics
    • Binary Fate Decisions: Pathways of Sex Determination
    • Drosophila Sex Determination: Every Cell for Itself
    • Sex Determination in Mammals: Coordinated Control by the Endocrine System
    • Binary Fate Decisions: the Germ Line Versus the Soma
    • Forming Complex Pattern: Establishing Positional Information
    • Forming Complex Pattern: Utilizing Positional Information to Establish Cell Fates
    • Additional Aspects of Pattern Formation
    • The Many Parallels in Vertebrate and Insect Pattern Formation
    • Summary
    • Concept Map
    • Solved Problem
    • Solved Problem
    • Solved Problem
    • Problems
  • Chapter 17. Population and Evolutionary Genetics
    • Darwin’s Revolution
    • Variation and its Modulation
    • The Effect of Sexual Reproduction on Variation
    • The Sources of Variation
    • Selection
    • Balanced Polymorphism
    • Multiple Adaptive Peaks
    • Artificial Selection
    • Random Events
    • A Synthesis of Forces
    • Summary
    • Concept Map
    • Solved Problem
    • Solved Problem
    • Solved Problem
    • Solved Problem
    • Problems
  • Chapter 18. Quantitative Genetics
    • Introduction
    • Some Basic Statistical Notions
    • Genotypes and Phenotypic Distribution
    • Norm of Reaction and Phenotypic Distribution
    • Determining Norms of Reaction
    • The Heritability of a Trait
    • Quantifying Heritability
    • Locating the Genes
    • More on Analyzing Variance
    • Summary
    • Concept Map
    • Statistical Appendix to Chapter 18
    • Measures of Central Tendency
    • Measures of Dispersion: The Variance
    • Measures of Relationship
    • Covariance and correlation
    • Solved Problem
    • Solved Problem
    • Solved Problem
    • Problems
  • Glossary
  • Further Readings

By agreement with the publisher, this book is accessible by the search feature, but cannot be browsed.

Copyright © 1999, W. H. Freeman and Company.
Bookshelf ID: NBK21248

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