Figure 12.4. Copper-regulated gene expression in Saccharomyces cerevisiae.

Figure 12.4Copper-regulated gene expression in Saccharomyces cerevisiae

Yeast requires low amounts of copper because a few of its enzymes (e.g. cytochrome c oxidase and tyrosinase) are copper-containing metalloproteins, but too much copper is toxic for the cell. When copper levels are low, the Mac1p protein factor is activated by copper binding and switches on expression of genes for copper uptake. When the copper levels are too high, a second factor, Ace1p, is activated, switching on expression of a different set of genes, these coding for proteins involved in copper detoxification.

From: Chapter 12, Regulation of Genome Activity

Cover of Genomes
Genomes. 2nd edition.
Brown TA.
Oxford: Wiley-Liss; 2002.
Copyright © 2002, Garland Science.

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