Table 146.3Characteristic Effects of Drugs and Treatments on Bone Marrow

TreatmentHematologic Complication
Most chemotherapeutic agentsLeukopenia and thrombocytopenia at 9–10 days; nadir counts at 14–18 days; recovery of counts at 21–28 days
NitrosoureaMyelosuppression at 4–6 weeks
Vincristine, L-asparaginase, bleomycin, methotrexate with leucovorinNo myelosuppression
Gamma irradiationChronic lymphopenia
Whole-body irradiationProfound suppression of humoral and cellular immune response

From: Chapter 146, Hematologic Complications and Blood Bank Support

Cover of Holland-Frei Cancer Medicine
Holland-Frei Cancer Medicine. 5th edition.
Bast RC Jr, Kufe DW, Pollock RE, et al., editors.
Hamilton (ON): BC Decker; 2000.
© 2000, BC Decker Inc.

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