Table 46.4Sensitivity of Neoplastic Diseases to MTX

Sensitive*Moderately SensitiveNot Sensitive
Acute lymphocytic leukemiaHead and neck cancerRenal cell carcinoma
Acute myelocytic leukemiaBreast cancerPancreatic cancer
Burkitt’s lymphomaBladder cancerColon cancer
Choriocarcinoma
Diffuse large cell lymphoma
*

Cures disease or is part of curative regimen.

Produces greater than 15% response rate.

From: Chapter 46, Folate Antagonists

Cover of Holland-Frei Cancer Medicine
Holland-Frei Cancer Medicine. 5th edition.
Bast RC Jr, Kufe DW, Pollock RE, et al., editors.
Hamilton (ON): BC Decker; 2000.
© 2000, BC Decker Inc.

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