Table 46.4Sensitivity of Neoplastic Diseases to MTX

Sensitive*Moderately SensitiveNot Sensitive
Acute lymphocytic leukemiaHead and neck cancerRenal cell carcinoma
Acute myelocytic leukemiaBreast cancerPancreatic cancer
Burkitt’s lymphomaBladder cancerColon cancer
Diffuse large cell lymphoma

Cures disease or is part of curative regimen.

Produces greater than 15% response rate.

From: Chapter 46, Folate Antagonists

Cover of Holland-Frei Cancer Medicine
Holland-Frei Cancer Medicine. 5th edition.
Bast RC Jr, Kufe DW, Pollock RE, et al., editors.
Hamilton (ON): BC Decker; 2000.
© 2000, BC Decker Inc.

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