Table 26.2The Effects of 13-cis Retinoic Acid on the Incidence of Primary-Treatment Failure and the Incidence of Second Primary Tumors in Squamous Cell Carcinoma of the Head and Neck

13-cisRetinoic AcidPlaceho
Type of Failure(N = 49)(N = 51)p value
Disease progression31%33%.772
Local8%14%.373
Regional16%14%.719
Distant14%10%.490
Second primary tumor4%24%.005

Retinoid treatment had no effect on the progression of the primary tumor but significantly reduced the incidence of second primary cancers. (see XXVII–1)

From Hong et al. Prevention of secondary primary tumors with isotretinoin in squamous-cell caranom of the head and neck. N Eng J Med 1990;323:1278.

From: Chapter 26, Nutrition in the Etiology and Prevention of Cancer

Cover of Holland-Frei Cancer Medicine
Holland-Frei Cancer Medicine. 5th edition.
Bast RC Jr, Kufe DW, Pollock RE, et al., editors.
Hamilton (ON): BC Decker; 2000.
© 2000, BC Decker Inc.

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