Figure 36.9. The effect of fluence rate and light fractionation on BPD-mediated PDT.

Figure 36.9

The effect of fluence rate and light fractionation on BPD-mediated PDT. BPD-MA was administered to rats with NBT II tumors implanted into the bladder wall. One hour later tumors were exposed to a total fluence of 30 J/cm2 of 690 nm irradiation under the following conditions: 100 mW/cm2 continuous; 100 mW/cm2 fractionated 15 s on/15 s off; 100 mW/cm2 30 s on/30 s off; 100 mW/cm2 60 s on/60 s off. Tumors were disaggregated 24 hours later and tumor cells were plated for colony formation assay. Colonies (50 cells or more) were counted 9 days later after fixing with methanol and staining with crystal violet. The Wilcoxon rank sum test was used to compare the number of clonogenic cells with data at 100 mW/cm2 and continuous wave irradiations. Source: Iinuma et al.53 Reproduced with permission.

From: Chapter 36, Photodynamic Therapy of Cancer

Cover of Holland-Frei Cancer Medicine
Holland-Frei Cancer Medicine. 5th edition.
Bast RC Jr, Kufe DW, Pollock RE, et al., editors.
Hamilton (ON): BC Decker; 2000.
© 2000, BC Decker Inc.

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