Figure 15.4. Heuristic scheme for excision repair of damaged sites on DNA in mammalian chromatin.

Figure 15.4

Heuristic scheme for excision repair of damaged sites on DNA in mammalian chromatin. The first step involves mechanisms that recognize damage and dissociate nucleoproteins to make the DNA accessible to repair enzymes. This is followed by sequential incision by a DNA polymerase, sealing of the patch by a polynucleotide ligase, and final reassembly and repackaging of nucleoprotein. (Reproduced with permission from Cleaver and Kraemer.116)

From: Chapter 15, Ultraviolet Radiation Carcinogenesis

Cover of Holland-Frei Cancer Medicine
Holland-Frei Cancer Medicine. 5th edition.
Bast RC Jr, Kufe DW, Pollock RE, et al., editors.
Hamilton (ON): BC Decker; 2000.
© 2000, BC Decker Inc.

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