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Table 43.3Cumulative Results from 2,300 Clinical Correlations Using Clonogenic Assays to Predict Clinical Treatment Outcome

ResultsNo. of Correlations%
True positive51269
True negative1,42791
False positive22631
False negative1359
Total2,300
Sensitivitya79
Specificityb86
Positive predictive valuec69
Negative predictive valued91
a

Sensitivity = true positives/true positives + false negatives

b

Specificity = true negatives/true negatives + false positives

c

Positive predictive value = true positives/true positives + false positives

d

Negative predictive value = true negatives/true negatives + false negatives

Source: Von Hoff.4

From: Chapter 43, In Vitro and In Vivo Predictive Tests

Cover of Holland-Frei Cancer Medicine
Holland-Frei Cancer Medicine. 5th edition.
Bast RC Jr, Kufe DW, Pollock RE, et al., editors.
Hamilton (ON): BC Decker; 2000.
© 2000, BC Decker Inc.

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