Figure 20.1. Histopathology of a classic human papillomavirus (HPV) infection (condyloma) of the cervix associated with low-risk HPV types (HPV types 6 or 11).

Figure 20.1

Histopathology of a classic human papillomavirus (HPV) infection (condyloma) of the cervix associated with low-risk HPV types (HPV types 6 or 11). A. Morphologic features of HPV infection include nuclear atypia in the superficial epithelial cells with prominent cytoplasmic halos (arrowheads). The lower cell layers contain minimal cytologic atypia. B. Appearance following in situ hybridization with a biotin-labeled mixed DNA probe containing HPV types 6 and 11 (VIRATYPE, Life Technologies, Gaithersburg, MD) The dark staining in the superficial cell nuclei and cytoplasm represent viral DNA and RNA produced during viral replication. C. An immunoperoxidase stain for HPV capsid proteins, highlighting several darkly staining nuclei in the superficial epithelium (arrowheads).

From: Chapter 20, Papillomaviruses and Cervical Neoplasia

Cover of Holland-Frei Cancer Medicine
Holland-Frei Cancer Medicine. 5th edition.
Bast RC Jr, Kufe DW, Pollock RE, et al., editors.
Hamilton (ON): BC Decker; 2000.
© 2000, BC Decker Inc.

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