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Bookshelf ID: NBK20777

Holland-Frei Cancer Medicine, 5th edition

Edited by Robert C Bast, Jr, MD, Donald W Kufe, MD, Raphael E Pollock, MD, PhD, Ralph R Weichselbaum, MD, James F Holland, MD, ScD (hc), and Emil Frei, III, MD.

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Hamilton (ON): BC Decker; 2000.

ISBN-10: 1-55009-113-1

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Cancer Medicine is the best known and respected work in the field of oncology and was the first comprehensive textbook devoted to reporting and assessing the rapid and continuous development in the diagnosis and treatment of cancer. Cancer Medicine is widely recognized as a leading reference resource for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. Cancer Medicine e.5 continues this high standard while providing updated information in all areas of oncology - including molecular biology, pathology, imaging interventional radiology, endoscopy, surgical oncology, radiation oncology, and medical oncology.

Editors
Contributors
Preface
Section 1. Cancer Biology
- Chapter 1. Molecular Biology
  Barrett J Rollins, MD, Todd R Golub, MD, Kornelia Polyak, MD, and Charles D Stiles, PhD.
- Chapter 2. Cell Proliferation, Differentiation, and Apoptosis
  Michael Andreeff, MD, David W Goodrich, MD, and Arthur B Pardee, MD.
- Chapter 3. Growth Factor Signal Transduction in Cancer
  Paolo Fedi, MD, Alec Kimmelman, MD, and Stuart A Aaronson, MD.
- Chapter 4. Oncogenes
  Marco A Pierotti, MD, Steven A Schichman, MD, Gabriella Sozzi, and Carlo M Croce, MD.
- Chapter 5. Tumor Suppressor Gene Defects in Human Cancer
  Eric R Fearon, MD and Bert Vogelstein, MD.
- Chapter 6. Recurring Chromosome Rearrangements in Human Cancer
  Olufunmilayo I Olopade, MD, Olatoyosi M Sobulo, MD, and Janet D Rowley, MD.
- Chapter 7. Biochemistry of Cancer
  Raymond W Ruddon, MD.
- Chapter 8. Invasion and Metastases
  Lance A Liotta, MD and Elise C Kohn, MD.
- Chapter 9. Tumor Angiogenesis
  Judah Folkman, MD.
Section 2. Tumor Immunology
- Chapter 10. Tumor Immunology
  Jeffrey Schlom, PhD and Scott I Abrams, PhD.
Section 3. Cancer Etiology
- Chapter 11. Genetic Predisposition to Cancer
  Marcia S Brose, MD, Tom Smyrk, MD, Barbara Weber, MD, and Henry T Lynch, MD.
- Chapter 12. Chemical Carcinogenesis
  Ainsley Weston, PhD and Curtis C Harris, MD.
- Chapter 13. Hormones and the Etiology of Cancer
  Brian E Henderson, MD, Leslie Bernstein, PhD, and Ronald K Ross, MD.
- Chapter 14. Ionizing Radiation
  John B Little, MD.
- Chapter 15. Ultraviolet Radiation Carcinogenesis
  James E Cleaver, PhD and David L Mitchell, PhD.
- Chapter 16. Physical Carcinogens
  Cesare Maltoni, MD, Franco Minardi, MD, and James F Holland, MD.
- Chapter 17. Trauma and Inflammation
  John F Gaeta, MD.
- Chapter 18. Tumor Viruses
  Howard A Fine, MD and Joseph G Sodroski, MD.
- Chapter 19. Herpesviruses
  Jeffrey I Cohen, MD.
- Chapter 20. Papillomaviruses and Cervical Neoplasia
  Catherine M McLachlin, MD and Christopher P Crum, MD.
- Chapter 21. Hepatitis Viruses
  Max W Sung, MD, Swan N Thung, MD, and George Acs, MD.
- Chapter 22. Parasites
  Piero Mustacchi, MD.
Section 4. Cancer Epidemiology
- Chapter 23. Cancer Epidemiology
  Michael J Thun, MD and Phyllis A Wingo, PhD.
Section 5. Theory and Practice of Clinical Trials
- Chapter 24. Theory and Practice of Clinical Trials
  Marvin Zelen, PhD.
Section 6. Cancer Prevention
- Chapter 25. Prevention of Tobacco-Related Cancers
  Paul F Engstrom, MD, Margie Clapper, PhD, Robert A Schnoll, PhD, and C. Tracy Orleans, PhD.
- Chapter 26. Nutrition in the Etiology and Prevention of Cancer
  Steven K Clinton, MD, Elizabeth C Miller, MS, and Edward L Giovannucci, MD.
- Chapter 27. Chemoprevention of Cancer
  Michael B Sporn, MD and Scott M Lippman, MD.
Section 7. Cancer Screening and Early Detection
- Chapter 28. Cancer Screening and Early Detection
  Harmon J Eyre, MD, Robert A Smith, PhD, and Curtis J Mettlin, PhD.
Section 8. Principles of Cancer Pathology
- Chapter 29. Principles of Cancer Pathology
  James L Connolly, MD, Stuart J Schnitt, MD, Helen H Wang, MD, Ann M Dvorak, MD, and Harold F Dvorak, MD.
Section 9. Principles of Imaging
- Chapter 30. Principles of Imaging
  Richard J Steckel, MD.
- Chapter 30A. Imaging Cancer of Unknown Primary Site
  A. Robert Kagan, MD and Richard J Steckel, MD.
- Chapter 30B. Imaging Neoplasms of the Head and Neck and Central Nervous System
  Robert B Lufkin, MD.
- Chapter 30C. Imaging Neoplasms of the Thorax
  Poonam V Batra, MD.
- Chapter 30D. Imaging Neoplasms of the Abdomen and Pelvis
  Robert A Halvorsen Jr, MD and William M Thompson, MD.
- Chapter 30E. Cross-Sectional Imaging of Musculoskeletal Neoplasms
  Leanne L Seeger, MD.
- Chapter 30F. Imaging the Breast
  Lawrence W Bassett, MD.
- Chapter 30G. Ultrasound in Cancer Medicine
  Edward G Grant, MD.
- Chapter 30H. Radionuclide Imaging in Cancer Medicine
  Randall A Hawkins, MD.
- Chapter 30I. Perspectives in Imaging
  Richard J Steckel, MD.
- Chapter 31. Interventional Radiology for the Cancer Patient
  Marshall Hicks, MD, Chusilp Charnsangavej, MD, and Michael Wallace, MD.
Section 10. Principles of Surgical Oncology
- Chapter 32. Principles of Surgical Oncology
  Raphael E Pollock, MD and Donald L Morton, MD.
- Chapter 33. Vascular Access in Cancer Patients
  Michail Shafir, MD.
Section 11. Principles of Radiation Oncology
- Chapter 34. Physical and Biologic Basis of Radiation Oncology
  Arno J Mundt, MD, John C Roeske, PhD, and Ralph R Weichselbaum, MD.
- Chapter 35. Principles of Hyperthermia
  Daniel S Kapp, PhD, George M Hahn, PhD, and Robert W Carlson, MD.
- Chapter 36. Photodynamic Therapy of Cancer
  Tayyaba Hasan, PhD, Anne C E Moor, PhD, and Bernard Ortel, MD.
Section 12. Principles of Medical Oncology
- Chapter 37. Principles of Medical Oncology
  James F Holland, MD, Emil Frei III, MD, Donald W Kufe, MD, and Robert C Bast Jr, MD.
Section 13. Principles of Chemotherapy
- Chapter 38. Cytokinetics
  Teresa Ann Gilewski, MD, Chau Dang, MD, Antonella Surbone, MD, and Larry Norton, MD.
- Chapter 39. Drug Resistance and Its Clinical Circumvention
  Charles S Morrow, MD and Kenneth H Cowan, MD.
- Chapter 40. Principles of Dose, Schedule, and Combination Chemotherapy
  Emil Frei III, MD and Karen H Antman, MD.
- Chapter 41. Regional Chemotherapy
  Maurie Markman, MD.
- Chapter 42. Animal Models in Developmental Therapeutics
  Samir N Khleif, MD and Gregory A Curt, MD.
- Chapter 43. In Vitro and In Vivo Predictive Tests
  A. R Hanauske, MD.
- Chapter 44. Pharmacology
  Mark J Ratain, MD and William Plunkett, MD.
- Chapter 45. Toxicology by Organ System
  Michael R Grever, MD and Charles K Grieshaber, PhD.
Section 14. Chemotherapeutic Agents
- Chapter 46. Folate Antagonists
  Barton A Kamen, MD, Peter D Cole, MD, and Joseph R Bertino, MD.
- Chapter 47. Pyrimidine and Purine Antimetabolites
  Giuseppe Pizzorno, MD, Robert E Handschumacher, MD, and Yung-Chi Cheng, MD.
- Chapter 48. Alkylating Agents and Platinum Antitumor Compounds
  D. Michael Colvin, MD.
  - Alkylating Agents
  - References
- Chapter 49. Anthracyclines and DNA Intercalators/Epipodophyllotoxins/DNA Topoisomerases
  Eric H Rubin, MD and William N Hait, MD.
- Chapter 50. Microtubule-Targeting Anticancer Drugs Derived from Plants and Microbes: Vinca Alkaloids, Taxanes, and Epothilones
  William T Beck, PhD, Carol E Cass, PhD, and Peter J Houghton, PhD.
- Chapter 51. Asparaginase
  JoAnne Kurtzberg, MD.
Section 15. Principles of Endocrine Therapy
- Chapter 52. Steroid Hormone Binding and Hormone Receptors
  Eugene R DeSombre, PhD and Elwood V Jensen, PhD.
- Chapter 53. Hypothalamic and Other Peptide Hormones
  Andrew V Schally, PhD and Ana Maria Comaru-Schally, MD.
- Chapter 54. Corticosteroids
  Lorraine I McKay, PhD and John A Cidlowski, PhD.
- Chapter 55. Estrogens and Antiestrogens
  V. Craig Jordan, PhD.
- Chapter 56. Clinical Use of Aromatase Inhibitors in Breast Carcinoma
  Harold A Harvey, MD.
- Chapter 57. Progestins
  Kenneth S McCarty Jr, MD and Kenneth S McCarty Sr, PhD.
- Chapter 58. Androgen Deprivation Strategies in the Treatment of Advanced Prostate Cancer
  Samuel R Denmeade, MD and John T Isaacs, PhD.
- Chapter 59. Paraneoplastic Syndromes
  William D Odell, MD.
Section 16. Principles of Biotherapeutics
- Chapter 60. Immunostimulants
  Robert C Bast Jr, MD and Donald L Morton, MD.
- Chapter 61. Active Specific Immunotherapy with Vaccines
  Mepur H Ravindranath, PhD and Donald L Morton, MD.
- Chapter 62. Interferons
  Ernest C Borden, MD and Bryan R G Williams, PhD.
- Chapter 63. Cytokines: Biology and Applications in Cancer Medicine
  Elizabeth A Grimm, PhD.
- Chapter 64. Hematopoietic Growth Factors
  Razelle Kurzrock, MD.
- Chapter 65. Monoclonal Serotherapy
  Robert C Bast Jr, MD, Michael R Zalutsky, PhD, Robert J Kreitman, MD, Edward A Sausville, MD, and Arthur E Frankel, MD.
Section 17. Principles of Gene Therapy
- Chapter 66. Cancer Gene Therapy
  Donald W Kufe, MD, Sunil Advani, MD, and Ralph Weichselbaum, MD.
Section 18. Principles of Bone Marrow Transplantation
- Chapter 67. Autologous Bone Marrow and Stem Cell Transplantation
  William P Peters, MD, Caroline Hamm, MD, and Roy D Baynes, MD.
- Chapter 68. Transplantation of Allogeneic Hematopoietic Cells for the Treatment of Malignancies
  Richard J O’Reilly, MD, Esperanza B Papadopoulos, MD, and Trudy N Small, MD.
Section 19. Principles of Psycho-Oncology
- Chapter 69. Principles of Psycho-Oncology
  Jimmie C Holland, MD and Jane Gooen-Piels, PhD.
Section 20. Principles of Oncology Nursing
- Chapter 70. Principles of Oncology Nursing
  Mary Johnson, RN and Connie Henke Yarbro, RN.
Section 21. Principles of Cancer Rehabilitation Medicine
- Chapter 71. Principles of Cancer Rehabilitation Medicine
  Kristjan T Ragnarsson, MD and David C Thomas, MD.
Section 22. Principles of Multidisciplinary Management
- Chapter 72. Principles of Multidisciplinary Management
  James F Holland, MD, Emil Frei III, MD, Donald W Kufe, MD, Robert C Bast Jr, MD, Raphael E Pollock, MD, and Ralph R Weichselbaum, MD.
- Chapter 73. Palliative Care
  Alan C Carver, MD and Kathleen M Foley, MD.
Section 23. Principles of Societal Oncology
- Chapter 74. Ethical Aspects of Caring for Patients with Cancer
  Ezekiel J Emanuel, MD and Steven Joffe, MD.
- Chapter 75. Legal Aspects of Cancer
  Joseph M Taraska, PA.
- Chapter 76. The Government and Cancer Medicine
  John E Ultmann, MD, Marguerite Donoghue Baxter, RN, and Terry Lierman.
- Chapter 77. Clinical Oncology in a Changing Healthcare Environment
  Martin N Raber, MD and Joseph S Bailes, MD.
- Chapter 78. Outcomes Assessment
  Jane C Weeks, MD.
- Chapter 79. Questionable Cancer Therapies
  Barrie R Cassileth, PhD.
Section 24. Neoplasms of the Central Nervous System
- Chapter 80. Neoplasms of the Central Nervous System
  Michael D Prados, MD.
Section 25. Neoplasms of the Eye
- Chapter 81. Neoplasms of the Eye
  David H Abramson, MD, Ira J Dunkel, MD, and Beryl McCormick, MD.
Section 26. Neoplasms of the Endocrine Glands
- Chapter 82. Pituitary Neoplasms
  Aviva Abosch, MD and Charles B Wilson, MD.
- Chapter 83. Neoplasms of the Thyroid
  Steven I Sherman, MD and Ann M Gillenwater, MD.
- Chapter 84. Neoplasms of the Adrenal Cortex
  David E Schteingart, MD.
- Chapter 85. Neoplasms of the Neuroendocrine System and Neoplasms of the Gastroenteropancreatic Endocrine System
  Larry K Kvols, MD, Roger R Perry, MD, Aaron I Vinik, MD, Li-teh Wu, MD, Phillippe Chaninian, MD, Stephen B Baylin, MD, and Norman W Thompson, MD.
Section 27. Neoplasms of the Head and Neck
- Chapter 86. Head and Neck Cancer
  Gary L Clayman, MD, Scott M Lippman, MD, George E Laramore, MD, and Waun Ki Hong, MD.
- Chapter 87. Odontogenic Tumors
  George Thomas Gallagher, DMD and Gerald Shklar, DDS.
  - Clinical, Radiographic, and Histologic Features
  - References
Section 28. Neoplasms of the Thorax
- Chapter 88. Cancer of the Lung
  Ara A Vaporciyan, MD, Jonathan C Nesbitt, MD, Jin Soo Lee, MD, Craig Stevens, MD, Ritsuko Komaki, MD, and Jack A Roth, MD.
- Chapter 89. Malignant Mesothelioma
  A. Philippe Chahinian, MD and Harvey I Pass, MD.
- Chapter 90. Thymomas and Thymic
  A. Philippe Chahinian, MD.
- Chapter 91. Tumors of the Heart and Great Vessels
  A. Philippe Chahinian, MD, David E Gutstein, MD, and Valentin Fuster, MD.
- Chapter 92. Primary Germ Cell Tumors of the Thorax
  John D Hainsworth, MD and F. Anthony Greco, MD.
- Chapter 93. Metastatic Tumors in the Thorax
  Donald L Morton, MD and Perry Shen, MD.
Section 29. Neoplasms of the Alimentary Canal
- Chapter 94. Neoplasms of the Esophagus
  Mark K Ferguson, MD.
- Chapter 95. Neoplasms of the Stomach
  Howard W Bruckner, MD, John C Morris, MD, and Paul Mansfield, MD.
- Chapter 96. Primary Neoplasms of the Liver
  Paul F Engstrom, MD, Elin Sigurdson, MD, and Alison A Evans, PhD.
- Chapter 97. Treatment of Liver Metastases
  Nancy E Kemeny, MD and Yuman Fong, MD.
- Chapter 98. The Gallbladder
  Steven A Curley, MD.
  - Gallbladder Carcinoma
  - References
- Chapter 99. Diagnosis and Management of Biliary Tract Cancer
  Steven A Curley, MD.
- Chapter 100. Neoplasms of the Ampulla of Vater
  Douglas B Evans, MD and Robert A Wolff, MD.
- Chapter 101. Neoplasms of the Exocrine Pancreas
  Robert A Wolff, MD, James L Abbruzzese, MD, and Douglas B Evans, MD.
- Chapter 102. Neoplasms of the Small Intestine, Vermiform Appendix, and Peritoneum
  Erik Barquist, MD and Michael Zinner, MD.
- Chapter 103. Adenocarcinoma of the Colon and Rectum
  Howard W Bruckner, MD, John Pitrelli, MD, and Marnin Merrick, MD.
- Chapter 104. Neoplasms of the Anus
  Brenda Shank, MD, Warren E Enker, MD, and Marshall S Flam, MD.
Section 30. Neoplasms of the Genitourinary Tract
- Chapter 105. Renal Cell Carcinoma
  Jerome P Richie, MD, Philip W Kantoff, MD, and Charles L Shapiro, MD.
- Chapter 106. Neoplasms of the Renal Pelvis and Ureter
  Jerome P Richie, MD and Philip W Kantoff, MD.
- Chapter 107. Bladder Cancer
  Philip W Kantoff, MD, Anthony L Zietman, MD, and Kenneth Wishnow, MD.
- Chapter 108. Neoplasms of the Prostate
  William K OH, MD, Mark Hurwitz, MD, Anthony V D’Amico, MD, Jerome P Richie, MD, and Philip W Kantoff, MD.
- Chapter 109. Neoplasms of the Penis
  Victor A Marcial, MD, A. Puras, MD, and V. A Marcial-Vega, MD.
- Chapter 110. Neoplasms of the Testis
  Craig R Nichols, MD, Robert Timmerman, MD, Richard S Foster, MD, Bruce J Roth, MD, and Lawrence H Einhorn, MD.
Section 31. Neoplasms of the Female Reproductive Organs
- Chapter 111. Neoplasms of the Vulva and Vagina
  Jacob Rotmensch, MD and Arthur L Herbst, MD.
- Chapter 112. Neoplasms of the Cervix
  J. Taylor Wharton, MD and Guillermo Tortolero-Luna, MD.
- Chapter 113. Endometrial Cancer
  Carmel J Cohen, MD, Gillian M Thomas, MD, and George S Hagopian, MD.
- Chapter 114. Neoplasms of the Fallopian Tube
  Carmel J Cohen, MD, Gillian M Thomas, MD, and George S Hagopian, MD.
- Chapter 115. Ovarian Cancer
  Jonathan S Berek, MD, Gillian M Thomas, MD, and Robert F Ozols, MD.
- Chapter 116. Gestational Trophoblastic Disease
  Ross S Berkowitz, MD and Donald P Goldstein, MD.
- Chapter 117. Gynecologic Sarcomas
  Carmel J Cohen, MD, Gillian M Thomas, MD, and George S Hagopian, MD.
Section 32. Neoplasms of the Breast
- Chapter 118. Neoplasms of the Breast
  Richard G Margolese, MD, Bernard Fisher, MD, Gabriel N Hortobagyi, MD, and William D Bloomer, MD.
Section 33. Neoplasms of the Skin
- Chapter 119. Neoplasms of the Skin
  Thomas B Fitzpatrick, MD.
Section 34. Malignant Melanoma
- Chapter 120. Malignant Melanoma
  Donald L Morton, MD, Richard Essner, MD, John M Kirkwood, MD, and Robert C Wollman, MD.
Section 35. Neoplasms of the Bone and Soft Tissue
- Chapter 121. Bone Tumors
  Gerald Rosen, MD, Charles A Forscher, MD, Henry J Mankin, MD, and Michael T Selch, MD.
- Chapter 122. Sarcomas of Nonosseous Tissues
  Peter W T Pisters, MD, Brian O’Sullivan, MD, and George D Demetri, MD.
Section 36. Neoplasms of the Hematopoitic System
- Chapter 123. Myelodysplastic Syndrome
  Lewis R Silverman, MD.
- Chapter 124. Acute Myeloid Leukemia in Adults
  Charles A Schiffer, MD and Richard M Stone, MD.
- Chapter 125. Chronic Myeloid Leukemia
  Richard T Silver, MD.
- Chapter 126. Acute Lymphocytic Leukemia in Adults
  Charles A Schiffer, MD and Richard A Larson, MD.
- Chapter 127. Chronic Lymphocytic Leukemia
  Kanti R Rai, MD and Michael J Keating, MD.
- Chapter 128. Hairy-Cell Leukemia
  Harvey M Golomb, MD and James Vardiman, MD.
- Chapter 129. Hodgkin’s Disease
  Peter Mauch, MD and James O Armitage, MD.
- Chapter 130. Non–Hodgkin’s Lymphomas
  Arnold S Freedman, MD and Lee M Nadler, MD.
- Chapter 131. Mycosis Fungoides and the Sézary Syndrome
  Youn H Kim, MD and Richard T Hoppe, MD.
- Chapter 132. Plasma Cell Tumors
  Kenneth C Anderson, MD.
- Chapter 133. Mast Cell Leukemia and Other Mast Cell Neoplasms
  Richard M Stone, MD and Steven H Bernstein, MD.
- Chapter 134. Polycythemia Vera and Essential Thrombocythemia
  Scott Murphy, MD.
Section 37. Neoplasms in AIDS
- Chapter 135. Neoplasms in Acquired Immunodeficiency Syndrome
  David T Scadden, MD.
Section 38. Neoplasms of Unknown Primary Site
- Chapter 136. Neoplasms of Unknown Primary Site
  John D Hainsworth, MD and F. Anthony Greco, MD.
Section 39. Neoplasms in Children
- Chapter 137A. Principles and Practice of Pediatric Oncology
  Michael A Weiner, MD.
- Chapter 137B. Incidence, Origins, Epidemiology
  Leslie L Robison, PhD.
- Chapter 137C. Principles of Pediatric Radiation Oncology
  John C Breneman, MD and Ashwatha Narayana, MD.
- Chapter 137D. Late Effects of Treatment of Cancer in Children and Adolescents
  Daniel M Green, MD.
- Chapter 138A. Childhood Acute Lymphoblastic Leukemia
  Paul S Gaynon, MD, Michael E Trigg, MD, and Fatih M Uckun, MD.
- Chapter 138B. Pediatric Acute Myeloid Leukemia
  Richard Aplenc, MD and Beverly Lange, MD.
- Chapter 138C. Hodgkin’s Disease in Children and Adolescents
  Allen Chauvenet, MD, Cindy L Schwartz, MD, and Michael A Weiner, MD.
- Chapter 138D. Non-Hodgkin’s Lymphoma in Children
  Mitchell S Cairo, MD and Sherrie Perkins, MD.
- Chapter 138E. Langerhans’ Cell Histiocytosis
  Kara M Kelly, MD.
  - The Histiocytic Disorders
  - References
- Chapter 139A. Hepatic Tumors
  Marcio Henrique Malogolowkin, MD.
- Chapter 139B. Renal Tumors of Childhood
  Paul E Grundy, MD, Daniel M Green, MD, Norman E Breslow, PhD, Michael L Ritchey, MD, and Patrick R M Thomas, MB.
- Chapter 139C. Germ Cell Tumors
  Barbara Cushing, MD and Neyssa Marina, MD.
- Chapter 139D. Neuroblastoma
  Katherine K Matthay, MD and Darrell J Yamashiro, MD.
- Chapter 139E. Soft Tissue Sarcomas of Childhood
  Leonard H Wexler, MD and Lee J Helman, MD.
Section 40. Complications of Cancer and its treatment
- Chapter 140. Management of Cancer Pain
  Alan C Carver, MD and Kathleen M Foley, MD.
- Chapter 141. Anorexia and Cachexia
  Takao Ohnuma, MD.
- Chapter 142. Antiemetic Therapy
  Richard J Gralla, MD.
- Chapter 143. Neurologic Complications
  Lisa M DeAngelis, MD and Jerome B Posner, MD.
- Chapter 144. Dermatologic Complications of Cancer Chemotherapy
  Narin Apisarnthanarax, MD and Madeleine Duvic, MD.
- Chapter 145. Skeletal Complications
  Samuel Kenan, MD and Gabriel N Hortobagyi, MD.
- Chapter 146. Hematologic Complications and Blood Bank Support
  Kenneth C Anderson, MD.
- Chapter 147. Coagulopathic Complications of Cancer
  Sabine Eichinger, MD and Kenneth A Bauer, MD.
- Chapter 148. Urologic Complications
  Christopher J Logothetis, MD and Jose E Sarriera, MD.
- Chapter 149. Cardiac Complications
  Michael S Ewer, MD and Robert S Benjamin, MD.
- Chapter 150. Respiratory Complications
  Roy B Jones, PhD.
- Chapter 151. Liver Function and Hepatotoxicity in Cancer
  Laurie D DeLeve, MD.
- Chapter 152. Gastrointestinal Complications
  Frank A Sinicrope, MD and Bernard Levin, MD.
- Chapter 153. Oral Complications
  Stephen T Sonis, DMD.
- Chapter 154. Gonadal Complications
  Catherine E Klein, MD.
- Chapter 155. Endocrine Complications
  S. Jim Yeung, MD and Robert F Gagel, MD.
- Chapter 156. Secondary Cancers: Incidence, Risk Factors, and Management
  Susan R Rheingold, MD, Alfred I Neugut, MD, and Anna T Meadows, MD.
Section 41. Infections in Patients with Cancer
- Chapter 157. Infections in Patients with Cancer
  Kenneth V I Rolston, MD and Gerald P Bodey, MD.
Section 42. Oncologic Emergencies
- Chapter 158. Oncologic Emergencies
  John C Morris, MD and James F Holland, MD.
Section 43. Oncology and the Information Revolution
- Chapter 159. Oncology and the Information Revolution
  Edward P Ambinder, MD.

An approved publication of the American Cancer Society

Associate Editor: Ted S Gansler, MD, MBA, American Cancer Society, Atlanta, Georgia

Notice: The authors and publisher have made every effort to ensure that the patient care recommended herein, including choice of drugs and drug dosages, is in accord with the accepted standard and practice at the time of publication. However, since research and regulation constantly change clinical standards, the reader is urged to check the product information sheet included in the package of each drug, which includes recommended doses, warnings, and contraindications. This is particular important with new or infrequently used drugs.

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