Table 97.6Drugs for Hepatic Arterial Infusion (HAI)

DrugHalf-Life (min)Estimated Increased Exposure by HAI
Fluorouracil (FU)105–10=fold
5-Fluoro-2-deoxyuridine (FUDR)<10100–400=fold
Bischlorethylnitrosourea (BCNU)<56–7=fold
Mitomycin C<106–8=fold
Cisplatin20–304–7=fold
Adriamycin (doxorubicin hydrochloride)602–fold

From: Chapter 97, Treatment of Liver Metastases

Cover of Holland-Frei Cancer Medicine
Holland-Frei Cancer Medicine. 5th edition.
Bast RC Jr, Kufe DW, Pollock RE, et al., editors.
Hamilton (ON): BC Decker; 2000.
© 2000, BC Decker Inc.

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