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Cover of Molecular Biology of the Cell

Molecular Biology of the Cell, 3rd edition

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Author Information

,1 ,2 ,3 ,4 ,5 and 6.

1 University of California, San Francisco, USA
2 Department of Zoology, University of Cambridge, Cambridge, England
3 Imperial Cancer Research Fund Developmental Biology Unit, University of Oxford, England
4 MRC Laboratory for Molecular Cell Biology and Biology Department, University College London, England
5 Department of Cell Biology, John Innes Institute, Norwich, England
6 Cold Spring Harbor Laboratory, USA
New York: Garland Science; .
ISBN-10: 0-8153-1619-4


Molecular Biology of the Cell is chiefly concerned with eucaryotic cells, as opposed to bacteria, and its title reflects the prime importance of the insights that have come from the molecular approach. Part I and Part II of the book analyze cells from this perspective and cover the traditional material of cell biology courses. But molecular biology by itself is not enough. The eucaryotic cells that form multicellular animals and plants are social organisms to an extreme degree: they live by cooperation and specialization. To understand how they function, one must study the ways cells in multicellular communities, as well as the internal workings of cells in isolation. These are two very different levels of investigation, but each depends on the other for focus and direction. We have therefore devoted Part III of the book to the behavior of cells in multicellular animals and plants. Thus developmental biology, histology, immunobiology, and neurobiology are discussed at much greater length than in other cell biology textbooks. While this material may be omitted from a basic cell biology course, serving as optimal or supplementary reading, it represents an essential part of our knowledge about cells and should be especially useful to those who decide to continue with biological or medical studies. The broad coverage expresses our conviction that cell biology should be at the center of a modern biological education.


  • Part I. Introduction to the Cell
    • Chapter 1. The Evolution of the Cell
      • Introduction
      • From Molecules to the First Cell
      • From Procaryotes to Eucaryotes
      • From Single Cells to Multicellular Organisms
      • References
    • Chapter 2. Small Molecules, Energy, and Biosynthesis
      • Introduction
      • The Chemical Components of a Cell
      • Biological Order and Energy
      • Food and the Derivation of Cellular Energy
      • Biosynthesis and the Creation of Order
      • The Coordination of Catabolism and Biosynthesis
      • References
    • Chapter 3. Macromolecules: Structure, Shape, and Information
      • Introduction
      • Molecular Recognition Processes
      • Nucleic Acids
      • Protein Structure
      • Proteins as Catalysts
      • References
    • Chapter 4. How Cells Are Studied
      • Introduction
      • Looking at the Structure of Cells in the Microscope
      • Isolating Cells and Growing Them in Culture
      • Fractionation of Cells and Analysis of Their Molecules
      • Tracing and Assaying Molecules Inside Cells
      • References
  • Part II. Molecular Genetics
    • Chapter 5. Protein Function
      • Introduction
      • Making Machines Out of Proteins
      • The Birth, Assembly, and Death of Proteins
      • References
    • Chapter 6. Basic Genetic Mechanisms
      • Introduction
      • RNA and Protein Synthesis
      • DNA Repair
      • DNA Replication
      • Genetic Recombination
      • Viruses, Plasmids, and Transposable Genetic Elements
      • References
    • Chapter 7. Recombinant DNA Technology
      • Introduction
      • The Fragmentation, Separation, and Sequencing of DNA Molecules
      • Nucleic Acid Hybridization
      • DNA Cloning
      • DNA Engineering
      • References
    • Chapter 8. The Cell Nucleus
      • Introduction
      • Chromosomal DNA and Its Packaging
      • The Global Structure of Chromosomes
      • Chromosome Replication
      • RNA Synthesis and RNA Processing
      • The Organization and Evolution of the Nuclear Genome
      • References
    • Chapter 9. Control of Gene Expression
      • Introduction
      • An Overview of Gene Control
      • DNA-binding Motifs in Gene Regulatory Proteins
      • How Genetic Switches Work
      • Chromatin Structure and the Control of Gene Expression
      • The Molecular Genetic Mechanisms That Create Specialized Cell Types
      • Posttranscriptional Controls
      • References
  • Part III. Internal Organization of the Cell
    • Chapter 10. Membrane Structure
      • Introduction
      • The Lipid Bilayer
      • Membrane Proteins
      • References
    • Chapter 11. Membrane Transport of Small Molecules and the Ionic Basis of Membrane Excitability
      • Introduction
      • Principles of Membrane Transport
      • Carrier Proteins and Active Membrane Transport ,
      • Ion Channels and Electrical Properties of Membranes
      • References
    • Chapter 12. Intracellular Compartments and Protein Sorting
      • Introduction
      • The Compartmentalization of Higher Cells
      • The Transport of Molecules into and out of the Nucleus
      • The Transport of Proteins into Mitochondria and Chloroplasts
      • Peroxisomes
      • The Endoplasmic Reticulum
      • References
    • Chapter 13. Vesicular Traffic in the Secretory and Endocytic Pathways
      • Introduction
      • Transport from the ER Through the Golgi Apparatus
      • Transport from the Trans Golgi Network to Lysosomes
      • Transport from the Plasma Membrane via Endosomes: Endocytosis
      • Transport from the Trans Golgi Network to the Cell Surface: Exocytosis
      • The Molecular Mechanisms of Vesicular Transport and the Maintenance of Compartmental Diversity
      • References
    • Chapter 14. Energy Conversion: Mitochondria and Chloroplasts
      • Introduction
      • The Mitochondrion
      • The Respiratory Chain and ATP Synthase
      • Chloroplasts and Photosynthesis
      • The Evolution of Electron-Transport Chains
      • The Genomes of Mitochondria and Chloroplasts
      • References
    • Chapter 15. Cell Signaling
      • Introduction
      • General Principles of Cell Signaling
      • Signaling via G-Protein-linked Cell-Surface Receptors
      • Signaling via Enzyme-linked Cell-Surface Receptors
      • Target-Cell Adaptation
      • The Logic of Intracellular Signaling: Lessons from Computer-based "Neural Networks"
      • References
    • Chapter 16. The Cytoskeleton
      • Introduction
      • The Nature of the Cytoskeleton
      • Intermediate Filaments
      • Microtubules
      • Cilia and Centrioles
      • Actin Filaments
      • Actin-binding Proteins
      • Muscle
      • References
    • Chapter 17. The Cell-Division Cycle
      • Introduction
      • The General Strategy of the Cell Cycle
      • The Early Embryonic Cell Cycle and the Role of MPF
      • Yeasts and the Molecular Genetics of Cell-Cycle Control
      • Cell-Division Controls in Multicellular Animals
      • References
    • Chapter 18. The Mechanics of Cell Division
      • Introduction
      • An Overview of M Phase
      • Mitosis
      • Cytokinesis
      • References
  • Part IV. Cells in Their Social Context
    • Chapter 19. Cell Junctions, Cell Adhesion, and the Extracellular Matrix
      • Introduction
      • Cell Junctions
      • Cell-Cell Adhesion
      • The Extracellular Matrix of Animals
      • Extracellular Matrix Receptors on Animal Cells: The Integrins
      • The Plant Cell Wall
      • References
    • Chapter 20. Germ Cells and Fertilization
      • Introduction
      • The Benefits of Sex
      • Meiosis
      • Eggs
      • Sperm
      • Fertilization
      • References
    • Chapter 21. Cellular Mechanisms of Development
      • Introduction
      • Morphogenetic Movements and the Shaping of the Body Plan
      • Cell Diversification in the Early Animal Embryo ,
      • Cell Memory, Cell Determination, and the Concept of Positional Values
      • The Nematode Worm: Developmental Control Genes and the Rules of Cell Behavior
      • Drosophila and the Molecular Genetics of Pattern Formation. I. Genesis of the Body Plan
      • Drosophila and the Molecular Genetics of Pattern Formation. II. Homeotic Selector Genes and the Patterning of Body Parts ,
      • Plant Development
      • Neural Development
      • References
    • Chapter 22. Differentiated Cells and the Maintenance of Tissues
      • Introduction
      • Maintenance of the Differentiated State
      • Tissues with Permanent Cells
      • Renewal by Simple Duplication
      • Renewal by Stem Cells: Epidermis ,
      • Renewal by Pluripotent Stem Cells: Blood Cell Formation ,
      • Genesis, Modulation, and Regeneration of Skeletal Muscle
      • Fibroblasts and Their Transformations: The Connective-Tissue Cell Family
      • Appendix
      • References
    • Chapter 23. The Immune System
      • Introduction
      • The Cellular Basis of Immunity
      • The Functional Properties of Antibodies
      • The Fine Structure of Antibodies
      • The Generation of Antibody Diversity
      • T Cell Receptors and Subclasses
      • MHC Molecules and Antigen Presentation to T Cells
      • Cytotoxic T Cells
      • Helper T Cells and T Cell Activation
      • Selection of the T Cell Repertoire
      • References
    • Chapter 24. Cancer
      • Introduction
      • Cancer as a Microevolutionary Process
      • The Molecular Genetics of Cancer
      • References

Bruce Alberts received his PhD from Harvard University and is currently President of the National Academy of Sciences and Professor of Biochemistry and Biophysics at the University of California, San Francisco. Dennis Bray received his PhD from the Massachusetts Institute of Technology and is currently a Medical Research Council Fellow in the Department of Zoology, University of Cambridge. Julian Lewis received his DPhil from the University of Oxford and is currently a Senior Scientist in the Imperial Cancer Research Fund Development Biology Unit, University of Oxford. Martin Raff received his MD from McGill University and is currently a Professor in the MRC Laboratory for Molecular Cell Biology and the Biology Department, University College London. Keith Roberts received his PhD from the University of Cambridge and is currently Head of the Department of Cell Biology, the John Innes Institute, Norwich. James D Watson received his PhD from Indiana University and is currently Director of Cold Spring Harbor Laboratory. He is the author of Molecular Biology of the Gene and, with Francis Crick and Maurice Wilkins, won the Nobel Peace Prize in Medicine and Physiology in 1962.

By agreement with the publisher, this book is accessible by the search feature, but cannot be browsed.

Copyright © 1994, Bruce Alberts, Dennis Bray, Julian Lewis, Martin Raff, Keith Roberts, and James D Watson.
Bookshelf ID: NBK20684


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