Cover of Asbestos

Asbestos

Selected Cancers

.

Washington (DC): National Academies Press (US); .
ISBN-10: 0-309-10169-7
Copyright © 2006, National Academy of Sciences.
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Excerpt

The committee was charged with reviewing evidence on a widely used material that is known to cause respiratory malignancy. Asbestos has been extensively investigated, epidemiologically and experimentally, as a cause of mesothelioma and lung cancer. However, its potential to cause malignancy at other sites that may also receive a substantial dose of asbestos fibers has not been as extensively investigated.

The committee considered the existing evidence from in vitro and animal experimentation to gain an understanding of mechanisms of carcinogenesis that might plausibly apply to the tissues in question and to determine the extent of toxicologic support for the development of cancers at the specified sites following asbestos exposure. Much of the information reviewed by the committee came from cohort studies of workers that focused on investigating respiratory effects and that reported information on risks of other diseases, including the cancers covered by this committee's charge, only incidentally. Other evidence came from case-control studies that were directed at the causes of the cancers of interest but that were not specifically designed to address asbestos exposure, and their exposure assessments were of varied quality.

This study was supported by Contract N01-OD-4-2139 between the National Academy of Sciences and the National Institutes of Health. Any opinions, findings, conclusions, or recommendations expressed in this publication are those of the author(s) and do not necessarily reflect the view of the organizations or agencies that provided support for this project.

NOTICE: The project that is the subject of this report was approved by the Governing Board of the National Research Council, whose members are drawn from the councils of the National Academy of Sciences, the National Academy of Engineering, and the Institute of Medicine. The members of the committee responsible for the report were chosen for their special competences and with regard for appropriate balance.

Copyright © 2006, National Academy of Sciences.
Bookshelf ID: NBK20332PMID: 20669440DOI: 10.17226/11665