Figure 3.9. Some representatives of class I (metal-independent) aldolase family in the SCOP database.

Figure 3.9Some representatives of class I (metal-independent) aldolase family in the SCOP database

This SCOP family unites enzymes with rather low sequence conservation (according to FSSP alignments, dihydrodipicolinate synthase and fructose-1,6-bisphosphate aldolase have only 10% identical residues), which have, however, a common catalytic mechanism that includes substrate binding to a conserved Lys residue resulting in a formation of Schiff-base intermediate. This serves as supplemental evidence for inferring homology of these enzymes.

From: Chapter 3, Information Sources for Genomics

Cover of Sequence - Evolution - Function
Sequence - Evolution - Function: Computational Approaches in Comparative Genomics.
Koonin EV, Galperin MY.
Boston: Kluwer Academic; 2003.
Copyright © 2003, Kluwer Academic.

NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.