FIGURE 8.6. Comparison of FA and ISI signals over active cortex.

FIGURE 8.6

Comparison of FA and ISI signals over active cortex. (A) Image of cat primary visual cortex under green (530–550 nm) illumination to highlight vascular pattern. (B) Standard deviation of the FA signal over an orientation mapping session—the brighter the pixel, the more sharply it is tuned for stimulus orientation. (C) Standard deviation of the ISI signal over the same imaging session. The modulation of the ISI signal occurs primarily over blood vessels, whereas the FA modulation is strongest over active neural tissue (as revealed by the distinct orientation domain pattern). (D) Autocorrelation of FA iso-orientation map from the same region of cortex shows distinct peaks that represent orientation domains. (E) The autocorrelation function of an ISI iso-orientation map shows long range correlations on the order of orientation domain size. (Modified from Husson, T.R. et al. [2007]. J. Neurosci 27[32], 8665–8675. With permission.)

From: Chapter 8, Functional Imaging with Mitochondrial Flavoprotein Autofluorescence: Theory, Practice, and Applications

Cover of In Vivo Optical Imaging of Brain Function
In Vivo Optical Imaging of Brain Function. 2nd edition.
Frostig RD, editor.
Boca Raton (FL): CRC Press; 2009.
Copyright © 2009, Taylor & Francis Group, LLC.

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