• We are sorry, but NCBI web applications do not support your browser and may not function properly. More information

Table 2. Combined Immunodeficiencies in the Differential Diagnosis of ZAP70-Related SCID

Disease NameGene InvolvedMode of InheritanceLymphocyte Phenotype
Familial CD8 deficiencyCD8AAR+++CD4+/CD8
CD25 deficiency IL2RAAR+++CD4/CD8+
MHC II deficiency (BLS)See Major histocompatibility complex (below) AR+++CD4/CD8+

MHC II = major histocompatibility complex class II

BLS = bare lymphocyte syndrome

From: ZAP70-Related Severe Combined Immunodeficiency

Cover of GeneReviews®
GeneReviews® [Internet].
Pagon RA, Adam MP, Ardinger HH, et al., editors.
Seattle (WA): University of Washington, Seattle; 1993-2014.
Copyright © 1993-2014, University of Washington, Seattle. All rights reserved.

For more information, see the GeneReviews Copyright Notice and Usage Disclaimer.

For questions regarding permissions: ude.wu@tssamda.

NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.