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Table 2. Combined Immunodeficiencies in the Differential Diagnosis of ZAP70-Related SCID

Disease NameGene InvolvedMode of InheritanceLymphocyte Phenotype
TBNKOther
Familial CD8 deficiencyCD8AAR+++CD4+/CD8
CD25 deficiency IL2RAAR+++CD4/CD8+
MHC II deficiency (BLS)See Major histocompatibility complex (below) AR+++CD4/CD8+

MHC II = major histocompatibility complex class II

BLS = bare lymphocyte syndrome

From: ZAP70-Related Severe Combined Immunodeficiency

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