Figure 5. Speculative model for the role of the tra-2 and fem-3 3′UTR elements in controlling the pattern of cell fates in the hermaphrodite germ line.

Figure 5

Speculative model for the role of the tra-2 and fem-3 3′UTR elements in controlling the pattern of cell fates in the hermaphrodite germ line. (Top) Translational activity of tra-2 or fem-3 ; (bottom) pattern of cell fates. Pattern is generated as differentiation proceeds from proximal (left) to distal (right). First, repression of tra-2 is required for the onset of spermatogenesis. DRF is proposed to bind DREs during larval development, thereby repressing tra-2 translation and permitting spermatogenesis. fem-3 , which is translationally active at this time, directs spermatogenesis for a period of hours in the proximal region of the gonad. At later times, repression of fem-3 is required for the switch from spermatogenesis to oogenesis. PMF is proposed to bind the PME, thereby repressing fem-3 translation and permitting oogenesis. The translational activity of tra-2 during oogenesis is at present unknown. (Reprinted, with permission, from Wickens et al. 1996.)

From: Section IV, Regulation of Translation During Development

Cover of C. elegans II
C. elegans II. 2nd edition.
Riddle DL, Blumenthal T, Meyer BJ, et al., editors.
Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 1997.
Copyright © 1997, Cold Spring Harbor Laboratory Press.

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