FIGURE 18.2. (A) O-GlcNAcylated proteins occur in many different cellular compartments.

FIGURE 18.2

(A) O-GlcNAcylated proteins occur in many different cellular compartments. Found mostly within the nucleus, they are also in the cytoplasm and within viruses that infect eukaryotic cells. The subcellular distribution of O-GlcNAc is similar to that of Ser(Thr)-O-phosphorylation. (Redrawn, with permission, from Comer F.I. and Hart G.W. 2000. J. Biol. Chem. 275: 29179–29182.) (B) O-GlcNAcylated proteins belong to many different functional classes. Pie chart illustrates the functional distribution of O-GlcNAcylated proteins identified thus far. (Redrawn, with permission, from Love D.C. and Hanover J.A. 2005. Science STKE 312: re13.)

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From: Chapter 18, The O-GlcNAc Modification

Cover of Essentials of Glycobiology
Essentials of Glycobiology. 2nd edition.
Varki A, Cummings RD, Esko JD, et al., editors.
Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 2009.
Copyright © 2009, The Consortium of Glycobiology Editors, La Jolla, California.

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