Figure 4. Construction and replication cycle of self-inactivating vector.

Figure 4

Construction and replication cycle of self-inactivating vector. The enhancers and/or promoter in the 3′LTR of a standard retroviral vector (top) is deleted to make the self-inactivating vector (middle), which, after reverse transcription, has partially deleted LTRs at both ends (bottom). Arrows indicate promoters.

From: Principles of Retroviral Vector Design

Cover of Retroviruses
Retroviruses.
Coffin JM, Hughes SH, Varmus HE, editors.
Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 1997.
Copyright © 1997, Cold Spring Harbor Laboratory Press.

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