Table 2Retroviruses Containing Oncogenes

Biochemical function of oncogene productOncogeneVirus(es)OriginTumora Mode of
expression
Helper
virus
CommentsReferences
Nonreceptor PTK src RSVchickensarcomav-src nonemultiple isolates Rous (1911); Payne (1992)
fps FuSV-ASVchickensarcoma gag-fps fusionALV fes homolog Fujinami and Inamoto (1914)
PRCII-ASVchickensarcoma gag-fps fusionALV Carr and Campbell (1958)
PRCIV-ASVchickensarcoma gag-fps fusionALV Carr and Campbell (1958)
UR1-ASVchickensarcoma gag-fps fusionALV Balduzzi et al. (1981)
16L-ASVchickensarcoma gag-fps fusionALV Neel et al. (1982a)
fes ST-FeSVcatsarcoma gag-fes fusionFeLV fps homolog Snyder and Theilen (1969)
GA-FeSVcatsarcoma gag-fes fusionFeLV Gardner et al. (1970)
HZ1-FeSVcatsarcoma gag-fes fusionFeLV Snyder et al. (1984)
yes Y-73-ASVchickensarcoma gag-yes fusionALV Itohara et al. (1978)
ESV-ASVchickensarcoma gag-yes fusionALV Wallbank et al. (1966)
fgr GR-FeSVcatsarcoma gag-actin-fgr fusionFeLV Rasheed et al. (1982)
TP1-FeSVcatsarcoma gag-fgr fusionFeLV Ziemiecki et al. (1984)
abl Ab-MLVmousepre-B lymphoma gag-abl fusionMo-MLV Abelson and Rabstein (1970)
HZ2-FeSVcatsarcoma gag-abl-pol fusionFeLV Besmer et al. (1983b)
Receptor PTK ros UR2-ASVchickensarcoma gag-ros fusionALVrelated to insulin receptor Balduzzi et al. (1981)
erbB AEV-ES4chickenerythroblastosisv-erbB ALVEGF receptor; also has v-erbA Engelbreth-Holm and Rothe-Meyer (1935)
AEV-Rchickenerythroblastosisv-erbB ALValso has v-erbA Engelbreth-Holm and Rothe-Meyer (1935)
AEV-Hchickenerythroblastosisv-erbB ALVrepresentative of many strains carrying only v-erbB Hihara et al. (1983)
fms SM-FeSVcatsarcoma gag-fms fusionFeLVCSF-1 receptor McDonough et al. (1971)
HZ5-FeSVcatsarcoma gag-fms fusionFeLV Besmer et al. (1986a)
kit HZ4-FeSVcatsarcoma gag-kit fusionFeLVSCL receptor Besmer et al. (1986b)
sea S13-AEVchickenerythroblastosis/ sarcoma env-sea fusionALVHGFR family member Beug et al. (1985)
eyk RPL30chickensarcoma env-eyk fusionALVformerly called ryk Fredrickson et al. (1964); Jia et al. (1992)
G protein ras K Ki-MSVratsarcoma/erythroleukemiav-ras Ki-MLValso has VL30 sequences Kirsten and Mayer (1967)
NY-FeSVcatsarcoma?v-ras FeLV Youngren and deNoronha (1983)
ras H Ha-MSVratsarcoma/erythroleukemiav-ras Mo-MLValso has VL30 sequences Harvey (1964)
RaSVratsarcoma/erythroleukemia gag-ras fusionRaLVisolated in vitro Rasheed et al. (1978)
Ba-MSVmousehemangiosarcomav-ras ecotropic MLV v-onc formerly called bas; virus formerly called 138-MSV Peters et al. (1974)
MHV-MSVmousehistiocytosisv-ras Fr-MLV Franz et al. (1985)
C58-MSVmousesarcoma/erythroleukemiav-ras ecotropic MLV Fredrickson et al. (1987)
Serine/ threonine kinase raf 3611-MSVmousesarcoma gag-raf fusionendogenous MLVsame as mil Rapp et al. (1983a)
mil MH2chickensarcoma/carcinoma/ myelocytoma gag-mil fusionALVsame as raf; also has v-myc Begg (1927)
R-mil IC10chicken?none gag-mil-env fusionRAV-1representative of several isolates derived in vitro; homolog of B-raf Marx et al. (1988)
akt AKT8mouseT-cell lymphoma gag-akt ecotropic MLV Staal et al. (1977)
mos Mo-MSVmousesarcoma env-mos fusionMo-MLV Moloney (1966)
Gz-MSVmousesarcomav-mos ecotropic MLV Gazdar et al. (1972)
MPV-MSVmousesarcoma/erythroleukemia, myeloid proliferationv-mos Fr-MLV Chirigos et al. (1968)
Growth factor sis SSVmonkeysarcoma env-sis fusionSSAVPDGF β-chain Wolff et al. (1971)
PI-FeSVcatsarcoma gag-sis fusionFeLV Irgens et al. (1973)
Adapter protein crk CT-10-ASVchickensarcoma gag-crk fusionALV Mayer et al. (1988)
ASV-1chickensarcoma gag-crk fusionALV Tsuchie et al. (1989)
Transcription factor ski SKV-ASVchickennone gag-ski-pol gag-pol-ski tdB77isolated in vitro Stavnezer et al. (1981)
erbA AEV-ES4chickenerythroblastosis gag-erbA fusionALVthyroid hormone receptor; also has v-erbB Engelbreth-Holm and Rothe-Meyer (1935)
AEV-Rchickenerythroblastosis gag-erbA fusionALValso has v-erbB Engelbreth-Holm and Rothe-Meyer (1935)
jun ASV-17chickensarcoma gag-jun fusionALVAP-1 component Cavalieri et al. (1985)
fos FBJ-MSVmouseosteosarcomav-fos ecotropic MLVAP-1 component Finkel et al. (1966)
FBR-MSVmouseosteosarcoma gag-fos-fox fusionecotropic MLV Finkel et al. 1973, 1975
NK-24chickenfibrosarcoma nephroblastoma gag-fos fusionALV Nishizawa et al. (1987)
myc MC29chickenmyelocytoma/ carcinoma gag-myc fusionALVcomplexes with Max Ivanov et al. (1964)
MH2chickencarcinoma/ myelocytomav-myc ALValso has v-mil Begg (1927)
CMIIchickenmyelocytoma/ carcinoma gag-myc fusionALV Loliger (1964)
OK10chickencarcinoma/ myelocytoma gag-pol-myc fusion, v-myc ALV Oker-Blom et al. (1975, 1978)
FH3chickencranial myelocytoma gag-myc fusionALV Chen et al. (1989)
GT3catT-cell lymphomav-myc FeLVrepresentative of several isolates Neil et al. (1984); Levy et al. (1984); Mullins et al. (1984); Onions et al. (1987)
myb BAI-AMVchickenmyeloblastosisv-myb ALV Hall et al. (1941)
E-26-AMVchickenmyeloblastosis erythroleukemia gag-myb-ets fusionALV Ivanov et al. (1962)
rel REV-Tturkeyreticuloendotheliosis env-rel-env fusionREAVNF-κB family member Robinson and Twiehaus (1974)
ets E26-AMVchickenerythroblastosis/ myeloblastosis gag-myb-ets fusionALV Ivanov et al. (1962)
maf AS42chickensarcoma gag-maf fusionALVbZip protein; can interact with Jun and Fos Kawai et al. (1992)
qin ASV-31chickensarcoma gag-qin fusionALVwinged helix family member Li and Vogt (1993)
Unclassified cbl Cas NS-1mousepre-B lymphoma/ myeloid leukemia gag-cbl fusionCas-MCFnuclear and cytoplasmic, binds DNA Langdon et al. (1989)
mpl MPLVmousemyeloproliferative disease env-mpl fusionFr-MLVcytokine receptor family member Wendling et al. (1986)

An explanation of the abbreviations used for the viruses in this table can be found in Appendix 1.

a

The type(s) of tumor that is most commonly found is listed. In many cases, a broader spectrum of tumors can be obtained depending on the age and genetic background of the host and the route of inoculation.

From: Oncogenesis

Cover of Retroviruses
Retroviruses.
Coffin JM, Hughes SH, Varmus HE, editors.
Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 1997.
Copyright © 1997, Cold Spring Harbor Laboratory Press.

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