NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.

Varki A, Cummings RD, Esko JD, et al., editors. Essentials of Glycobiology. 2nd edition. Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 2009.

Cover of Essentials of Glycobiology

Essentials of Glycobiology. 2nd edition.

Show details

Glossary

Correction

In the entry for Heparan sulfate, “(GlcNAcα1–4GlcAβ1–4IdoAα1–4) n” was changed to “(GlcNAcα1–4GlcAβ1–4/IdoAα1–4) n”.

In the entry for Complex glycan, “then” was changed to “than.” The entry now reads: “A glycan containing more than one type of monosaccharide.”

ABO

Gene locus comprising three major allelic glycosyl-transferases that generate the A, B, and O blood group antigens.

Acetal

An organic compound derived from a hemiacetal by reaction with an alcohol. If the hemiacetal is a sugar, then the acetal is a glycoside.

Adhesin

A protein on the surface of bacteria, viruses, or parasites that binds to a ligand present on the surface of a host cell.

Agglutination

The clumping of cells in the presence of a protein (e.g., antibody or lectin). The related term “hemagglutination” denotes the specific case wherein the cells are red blood cells.

Aglycone

Noncarbohydrate portion of a glycoconjugate or glycoside that is glycosidally linked to the glycan through the reducing terminal sugar.

Aldose

A monosaccharide with an aldehyde group or potential aldehydic carbonyl group (by definition, this is the C-1 position).

Amino sugar

A monosaccharide in which an alcoholic hydroxyl group is replaced by an amino group.

Anomeric carbon

The carbon atom of a monosaccharide that bears the hemiacetal functionality (C-1 for most sugars; C-2 for sialic acids).

Anomers

Stereoisomers of a monosaccharide that differ only in configuration at the anomeric carbon of the ring structure.

Antenna

A branch of an oligosaccharide emanating from a “core” structure.

Asparagine-linked oligosaccharide

See N-Glycan.

Azide

A functional group comprising three nitrogen atoms bound in a linear arrangement (N3).

Azido sugar

A monosaccharide to which an azido group has been introduced synthetically.

Bactoprenol

See Undecaprenol.

β-elimination

The cleavage of a C-O or C-N bond positioned on the β-carbon with respect to a carbonyl group. The process is used to cleave O-glycans from Ser or Thr residues.

Biofilm

Community of bacteria that adheres to a moist surface (e.g., surface of ponds or teeth).

C55 isoprenoid

See Undecaprenol.

Calnexin

Membrane-bound protein chaperone that mediates quality control of protein folding in the endoplasmic reticulum.

Calreticulin

Soluble protein chaperone that mediates quality control of protein folding in the endoplasmic reticulum.

Capsule

A protective extracellular polysaccharide coat surrounding certain bacteria. Presence of a capsular polysaccharide is often associated with virulence.

Carbohydrate

A generic term used interchangeably in this book with sugar, saccharide, or glycan. This term includes monosaccharides, oligosaccharides, and polysaccharides as well as derivatives of these compounds.

Carbohydrate-recognition domain

The domain of a polypeptide that is specifically involved in binding to carbohydrate. In lectins, it is often a highly evolutionarily conserved region of the polypeptide.

Cassette

A glycosylated amino acid used in solid-phase peptide synthesis to generate glycopeptides.

CAZy database

Denoting “carbohydrate active enzymes,” this database describes the families of structurally related catalytic and carbohydrate-binding modules (or functional domains) of enzymes that degrade, modify, or create glycosidic bonds.

Cellulose

A repeating homopolymer of β1–4-linked glucose residues.

Ceramide

The common lipid component of glycosphingolipids, composed of a long-chain amino alcohol (sphingosine) and an amide-linked fatty acid.

Cerebroside

A glycolipid composed of ceramide with an attached galactose (galactosylceramide) or glucose (glucosylceramide) residue.

Chemoenzymatic synthesis

Glycan synthesis that uses both chemical and enzymatic transformations to obtain the desired product.

Chitin

A repeating homopolymer of β1–4-linked N-acetyl-glucosamine residues. It is the main component of the cell walls of fungi and the exoskeletons of arthopods, among other functions.

Chondroitin sulfate

A type of glycosaminoglycan defined by the disaccharide unit (GalNAcβ1–4GlcAβ 1–3) n , modified with ester-linked sulfate at certain positions and typically found covalently linked to a proteoglycan core protein.

Complex glycan

A glycan containing more than one type of monosaccharide.

CRD

See Carbohydrate-recognition domain

C-type lectins

A class of Ca++-dependent lectins recognizable by a characteristic sequence that constitutes their carbohydrate-recognition domain.

Deoxy sugar

A monosaccharide in which a hydroxyl group is replaced by a hydrogen atom.

Dermatan sulfate

A modified form of chondroitin sulfate in which a portion of the D-glucuronate residues are epimerized to L-iduronates.

Dolichol

A polyisoprenoid lipid carrier utilized during the assembly of N-glycans and GPI anchors.

EGF-like repeats

See Epidermal growth factor-like repeats.

Electron transfer dissociation mass spectrometry

A technique used to determine sites of glycosylation on peptides and proteins.

Endoglycosidase

An enzyme that catalyzes the cleavage of an internal glycosidic linkage in an oligosaccharide or polysaccharide.

Endotoxin

See Lipid A.

Epidermal growth factor-like repeats

Small protein motifs (~40 amino acids) with six conserved cysteine residues that form three disulfide bonds. These often serve as sites for glycan modification.

Epimerase

An enzyme that catalyzes racemization of a chiral center in a sugar.

Epimers

Two isomeric monosaccharides differing only in the configuration of a single chiral carbon. For example, mannose is the C-2 epimer of glucose.

Epitope

The part of a molecule that is recognized by a specific antibody or receptor.

EPL

See Expressed protein ligation.

ETD mass spectrometry

See Electron transfer dissociation mass spectrometry.

Exoglycosidase

An enzyme that cleaves a monosaccharide from the outer (nonreducing) end of an oligosaccharide, polysaccharide, or glycoconjugate.

Exotoxins

Heat-labile, proteinaceous toxins secreted by bacteria that cause illness.

Expressed protein ligation

A method for generating semisynthetic proteins by the condensation of a synthetic peptide and a recombinant protein. Glycoproteins can be generated by condensation of a synthetic glycopeptide and a recombinant protein.

Extracellular matrix

A complex array of secreted molecules including glycoproteins, proteoglycans, and/or polysaccharides and structural proteins. In plants, the extracellular matrix is also referred to as the cell wall.

Extrinsic glycan-binding proteins

Receptors that recognize glycans from a different organism and consist mostly of pathogenic microbial adhesins, agglutinins, or toxins.

Fimbriae

Proteinaceous fiber-like appendages found in many Gram-negative bacteria.

Fischer projection

A two-dimensional representation of a three-dimensional organic molecule devised by Hermann Emil Fischer.

Fringe

Family of proteins that modify Notch activity by catalyzing the transfer of N-acetylglucosamine from UDP-GlcNAc to fucose on an EGF-like repeat.

Furanose

Five-membered (four carbons and one oxygen, i.e., an oxygen heterocycle) ring form of a monosaccharide named after the structural similarity to the compound furan.

Galectins

S-type (sulfhydryl-dependent) β-galactoside-binding lectins, usually occurring in a soluble form, expressed by a wide variety of animal cell types and distinguishable by the amino acid sequence of their carbohydrate-recognition domains.

Ganglioside

Anionic glycosphingolipid containing one or more residues of sialic acid.

Gene chip

A DNA microarray used to quantify transcript levels in high-throughput format.

Genome

The complete genetic sequence of one set of chromosomes.

Glycan

A generic term for any sugar or assembly of sugars, in free form or attached to another molecule, used interchangeably in this book with saccharide or carbohydrate.

Glycan array

A collection of glycans attached to a surface in a spatially addressed manner.

Glycan-binding proteins

Proteins that recognize and bind to specific glycans and mediate their biological function. See Lectin and Glycosaminoglycan-binding protein.

Glycation

The nonenzymatic, chemical modification of proteins by addition of carbohydrate, usually through a Schiff-base reaction with the amino group of the side chain of lysine and subsequent Amadori rearrangement to give a stable conjugate. Not to be confused with (enzymatic) glycosylation.

Glycobiology

Study of the structure, chemistry, biosynthesis, and biological functions of glycans and their derivatives.

Glycocalyx

The cell coat consisting of glycans and glycoconjugates surrounding animal cells that is seen as an electron-dense layer by electron microscopy.

Glycoconjugate

A molecule in which one or more glycan units are covalently linked to a noncarbohydrate entity.

Glycoforms

Different molecular forms of a glycoprotein, resulting from variable glycan structure and/or glycan attachment site occupancy.

Glycogen

A polysaccharide comprising α1–4 and α1–6-linked glucose residues that functions in short-term energy storage in animals; sometimes referred to as animal starch.

Glycogenin

A protein that acts as a primer for glycogen synthesis.

Glycolipid

General term denoting a molecule containing a glycan linked to a lipid aglycone. In higher organisms, most glycolipids are glycosphingolipids, but glycoglycerolipids and other types exist.

Glycome

The total collection of glycans synthesized by a cell, tissue, or organism under specified conditions of time, space, and environment.

Glycomics

Systematic analysis of the glycome.

Glycomimetics

Noncarbohydrate compounds that mimic the properties of glycans.

Glycone

Carbohydrate component of a glycoconjugate.

Glycopeptide

A peptide having one or more covalently attached glycans.

Glycoprotein

A protein with one or more covalently bound glycans.

Glycoproteomics

The systems-level analysis of glycoproteins, including their protein identities, sites of glycosylation, and glycan structures.

Glycosaminoglycans

Polysaccharide side chains of proteoglycans or free complex polysaccharides composed of linear disaccharide repeating units, each composed of a hexosamine and a hexose or a hexuronic acid. See Heparin, Heparan sulfate, Chondroitin sulfate, Dermatan sulfate, and Hyaluronan.

Glycosaminoglycan-binding proteins

Proteins that recognize and bind to specific glycosaminoglycans.

Glycosidase

An enzyme that catalyzes the hydrolysis of glycosidic bonds in a glycan. See Exoglycosidase and Endoglycosidase.

Glycoside

A glycan containing at least one glycosidic linkage to another glycan or an aglycone.

Glycosidic linkage

Linkage of a monosaccharide to another residue via the anomeric hydroxyl group. The linkage generally results from the reaction of a hemiacetal with an alcohol (e.g., a hydroxyl group on another monosaccharide or amino acid) to form an acetal. Glycosidic linkages between two monosaccharides have defined regiochemistry and stereochemistry.

Glycosphingolipid

Glycolipid comprising a glycan glycosidically attached to the primary hydroxyl group of ceramide.

Glycosyl acceptor

The nucleophile in a glycosylation reaction, usually containing a free hydroxyl group.

Glycosylation

The enzyme-catalyzed covalent attachment of a carbohydrate to a polypeptide, lipid, polynucleotide, carbohydrate, or other organic compound, generally catalyzed by glycosyltransferases, utilizing specific sugar nucleotide donor substrates.

Glycosyl donor

The electrophile in a glycosylation reaction; the nucleotide sugar in an enzymatic glycosylation reaction.

Glycosylphosphatidylinositol anchor

A membrane anchor that consists of a glycan bridge between phosphatidylinositol and ethanolamine in an amide linkage to the carboxyl terminus of a protein.

Glycosyltransferase

Enzyme that catalyzes transfer of a sugar from a sugar nucleotide donor to a substrate.

GPI anchor

See Glycosylphosphatidylinositol anchor.

Hapten

A small glycan that competes with a more complex ligand for binding to a lectin. More generally, any small molecule that interacts with a receptor or antibody.

Haworth projection

A representation of monosaccharides wherein the cyclic structures are depicted as planar rings with the hydroxyl groups orientated above or below the plane of the ring.

Hemagglutination

The clumping of red blood cells in the presence of a protein (e.g., antibody or lectin).

Hemagglutinin

A lectin that recognizes carbohydrates on the surface of red blood cells and causes hemagglutination.

Hemiacetal

A compound formed by reaction of an aldehyde with an alcohol group, as in ring closure of an aldose.

Hemiketal

A compound formed by reaction of a ketone with an alcohol group, as in ring closure of a ketose.

Heparan sulfate

A glycosaminoglycan defined by the disaccharide unit (GlcNAcα1–4GlcAβ1–4/IdoAα1–4) n , containing N- and O-sulfate esters at various positions, and typically found covalently linked to a proteoglycan core protein.

Heparin

A type of heparan sulfate made by mast cells that has the highest amount of iduronic acid and of N- and O-sulfate residues. Pharmaceutical heparin binds and activates antithrombin.

Heteropolysaccharide

A polysaccharide containing more than one type of monosaccharide.

Hexosamine

Hexose with an amino group in place of the hydroxyl group at the C-2 position. Common examples found in vertebrate glycans are the N-acetylated sugars, N-acetylglucosamine and N-acetylgalactosamine.

Hexose

A six-carbon monosaccharide typically with an aldehyde (or potential aldehyde) at the C-1 position (aldo-hexose) and hydroxyl groups at all other positions. Common examples in vertebrate glycans are mannose, glucose, and galactose.

Homopolysaccharide

A polysaccharide composed of only one type of monosaccharide.

Hyaluronan

A glycosaminoglycan defined by the disaccharide unit (GlcNAcβ1–4GlcAβ 1–3) n that is neither sulfated nor covalently linked to protein. It is referred to in older literature as hyaluronic acid.

Hydrazinolysis

A chemical method that uses hydrazine to cleave amide bonds (e.g., the glycosylamine linkage between a sugar residue and asparagine or the acetamide bond in N-acetylhexosamines).

Intrinsic glycan-binding proteins

Receptors that recognize glycans from the same organism. Typically they mediate cell–cell interactions or recognize extracellular molecules, but they can also recognize glycans on the same cell.

I-type lectins

A class of lectins belonging to the immunoglobulin superfamily.

Jelly-roll fold

Description of tertiary structure common to L-type lectins.

Keratan sulfate

A poly-N-acetyllactosamine [Galβ1–4GlcNAcβ 1–3] n with sulfate esters at C-6 of N-acetylglucosamine and galactose residues, found as a side chain of a keratan sulfate proteoglycan.

Ketal

An organic compound derived from a hemiketal by reaction with an alcohol. If the hemiketal is a sugar, then the ketal is a glycoside.

Ketose

A monosaccharide with a ketone group or a potential ketonic carbonyl group (typically at the C-2 position in natural monosaccharides).

Lactose

The disaccharide Galβ1–4Glc, an abundant milk sugar.

Lea

See Lewis blood group antigen

Lex

See Lewis blood group antigen

Ley

See Lewis blood group antigen

Lectin

A protein (other than a glycan-specific antibody) that specifically recognizes and binds to glycans without catalyzing a modification of the glycan.

Lewis blood group antigen

A related set of glycans that carry α1–3/α1–4 fucose residues covalently linked to galactose or N-acetylglucosamine.

Ligand

A molecule that is recognized by a specific receptor. In the case of lectins, the ligands are partly or completely glycan-based and are sometimes called counterreceptors.

Link module

A protein fold that interacts specifically with hyaluronan.

Lipid A

Also known as endotoxin. Lipid that contains fatty acids linked to glucosamine with a variable number of phosphate groups and 1–4 units of ketodeoxyoctulosonic acid (Kdo). See Lipopolysaccharide.

Lipid-linked oligosaccharide

An oligosaccharide linked to dolichol.

Lipid rafts

Small lateral microdomains of self-associating lipids in a membrane.

Lipooligosaccharide

Similar to lipopolysaccharide but lacking the O-antigen polysaccharide side chain repeats.

Lipopolysaccharide

A bacterial polysaccharide linked to a lipid moiety containing glucosamine rather than glycerol (lipid A) that makes up the major portion of the outer leaflet of the outer membrane of Gram-negative bacteria. A major determinant of antigenic specificity, also known as heat-stable toxin or endotoxin.

LLO

See Lipid-linked oligosaccharide.

LOS

See Lipooligosaccharide.

LPS

See Lipopolysaccharide.

L-type lectins

Superfamily of glycan-binding proteins with a common feature of tertiary structure called a “jelly-roll fold.”

Lysosomal storage disorders

Human genetic disorders in which defects in lysosomal enzymes result in the accumulation of various glycans in the lysosomes (e.g., Tay–Sachs disease).

Lysozyme

An endo-β-N-acetylhexosaminidase that cleaves the polysaccharide backbone of bacterial peptidoglycan.

Mannan

Mannose-rich polysaccharide found in certain bacteria, fungi, and plants.

Mannose-6-phosphate receptors

See P-type lectins.

MDOs

See Membrane-derived oligosaccharides.

Membrane-derived oligosaccharides

Highly charged β-glucans that create an osmotic buffer in the periplasmic space of Gram-negative bacteria.

Methylation analysis

A method for carbohydrate structure analysis based on the acid stability of methyl ethers and the acid lability of glycosidic linkages; used to determine the linkage positions of monosaccharide residues in an oligosaccharide chain.

Michael addition

The chemical reaction in which a nucleophile attacks the β-carbon of an α,β-unsaturated carbonyl compound. The reaction is used after O-glycan β-elimination in order to attach probes to those sites.

Microarray

A collection of molecules (e.g., DNA, proteins, or glycans) spatially addressed on a surface within features that have micrometer dimensions.

Microheterogeneity

Structural variations in the glycan at any given glycosylation site on a protein (one source of glycoforms).

Molecular mimicry

Strategy some microbial pathogens use to evade immune recognition by decorating themselves with glycans similar to those of their hosts.

Monosaccharide

Carbohydrate that cannot be hydrolyzed into a simpler carbohydrate. It is the building block of oligosaccharides and polysaccharides. Simple monosaccharides are polyhydroxyaldehydes or polyhydroxyketones with three or more carbon atoms.

Mucin

Large glycoprotein with a high content of serine, threonine, and proline residues and numerous O-GalNAc-linked saccharides, often occurring in clusters on the polypeptide.

Mucopolysaccharide

An out-of-date term replaced by the term “glycosaminoglycan.” It is still used as a group name for human disorders (“mucopolysaccharidoses”) involving glycosaminoglycan accumulation due to genetic deficiency of certain lysosomal enzymes.

Mutarotation

The interconversion of stereoisomers at the anomeric center of a monosaccharide.

N-acetyllactosamine

A disaccharide with the sequence Galβ1-4GlcNAc.

Native chemical ligation

A technique used to generate large polypeptides by condensation of smaller peptide fragments.

NCL

See Native chemical ligation.

Neuraminidase

See Sialidase.

N-Glycan

Glycan covalently linked to an asparagine residue of a polypeptide chain in the consensus sequence: -Asn-X-Ser/Thr. Unless otherwise stated, the term N-glycan is used generically in this book to denote the most common linkage region, Manβ1–4GlcNAcβ1–4GlcNAcβ1-N-Asn.

N-linked glycan

See N-Glycan.

N-linked oligosaccharide

See N-Glycan.

Nod factor

Lipooligosaccharide produced by Rhizobium bacteria that stimulates nodule formation and initiates nitrogen fixation in leguminous plants.

Nonreducing end

See Nonreducing terminus.

Nonreducing terminus

Outermost end of an oligosaccharide or polysaccharide chain, which is opposite to that of the reducing end.

Notch

Family of cell-surface receptors that are glycosylated on EGF-like repeats. Ligands include Delta and Serrate/Jagged.

Nucleotide sugars

Activated forms of monosaccharides, such as UDP-Gal, GDP-Fuc, and CMP-Sia, typically used as donor substrates by glycosyltransferases.

Nucleotide sugar transporters

Membrane-bound proteins that specifically transport nucleotide sugars from the cytosol into the lumen of intracellular organelles (e.g., the Golgi).

O-GalNAc glycan

See O-Glycan.

O-GlcNAcylation

Dynamic modification of proteins by β-linked N-acetylglucosamine (a posttranslational modification similar to protein phosphorylation).

O-Glycan

A glycan glycosidically linked to the hydroxyl group of the amino acids serine, threonine, tyrosine, or hydroxylysine. Unless otherwise stated, the term O-glycan is used in this book to denote the common linkage GalNAcα1-O-Ser/Thr.

Oligosaccharide

Linear or branched chain of monosaccharides attached to one another via glycosidic linkages. The number of monosaccharide units can vary; the term polysaccharide is usually reserved for large glycans with repeating units.

O-linked glycan

See O-Glycan

O-linked oligosaccharide

See O-Glycan

Optimer

A computer program used to determine the appropriate glycan building blocks in one-pot automated glycan synthesis.

PCR

See Polymerase chain reaction.

Peptidoglycan

A bacterial polysaccharide consisting of MurNAcβ1–4GlcNAcβ1–4 repeat units, covalently cross-linked to short peptides. Also known as murein, peptidoglycan represents the major structural component of the periplasm.

Periodate oxidation

A reagent that cleaves C-C bonds with vicinal hydroxyl groups (e.g., within carbohydrates) to form the two corresponding aldehydes.

Pili

Hair-like appendages on the surface of some bacteria that often contain adhesins. See also fimbriae

Polyisoprenoid

A lipid polymer composed of repeating units of the unsaturated five-carbon isoprene unit. See Dolichol and Undecaprenol.

Polymerase chain reaction

The process used to amplify DNA starting from a template DNA strand and complementary oligonucleotide primers.

Poly-N-acetyllactosamine

Repeating units of N-acetyllactosamines [Galβ1–4GlcNAcβ1–3] n of variable length (sometimes called PolyLacNAc).

Polysaccharide

Glycan composed of repeating monosaccharides, generally greater than ten monosaccharide units in length.

Polysialic acid

A homopolymer of sialic acids abundant in the brain and fish eggs and found on certain pathogenic bacteria.

Protecting group

A chemical moiety commonly used in glycan synthesis that masks hydroxyl groups in order to prevent them from reacting with other chemical reagents.

Proteoglycan

Any protein with one or more covalently attached glycosaminoglycan chains.

Proteome

The total collection of proteins in a cell, tissue, or organism, under specific conditions of time, space, and environment.

P-type lectins

Class of lectins that recognize mannose-6-phosphate (also called M6P receptors).

Pyranose

Six-membered (five carbons and one oxygen, i.e., an oxygen heterocycle) ring form of a monosaccharide; the most common form found for hexoses and pentoses. The name is based on the structural similarity to the compound “pyran.”

Receptor

A protein that binds to a ligand and initiates signal transmission or other cellular activity. In this book, most receptors are lectins (i.e., they recognize glycans). In microbiology, the terminology is reversed: Adhesins or agglutinins on the microbes bind to receptors, which are glycans on the host cell.

Reducing end

See Reducing terminus.

Reducing terminus

End of a glycan that has reducing power because it is unattached to an aglycone and is thus a hemiacetal or a hemiketal. In a glycoconjugate, reducing terminus is also used as a synonym for a potential reducing terminus, referring to the end of a glycan covalently attached to the aglycone by a glycosidic bond (i.e., it would have reducing power if it were released).

Regiochemistry

The region among many possible regions of a molecule that is involved in a chemical reaction. For glycosidic linkages, regiochemistry denotes the hydroxyl group of one monsaccharide that is bound to the anomeric position of the other (i.e., 1–3 vs. 1–4 linkage).

R-type lectins

Superfamily of glycan-binding proteins that contain a carbohydrate-recognition domain similar to that in ricin.

Saccharide

A generic term for any carbohydrate or assembly of carbohydrates, in free form or attached to another molecule, used interchangeably in this book with carbohydrate and glycan.

Saccharolipid

A glycoconjugate comprising fatty acyl chains covalently attached directly to a sugar backbone (e.g., lipid A).

Selectin

A C-type (Ca++-dependent) lectin expressed by cells in the vasculature and bloodstream. The three known selectins are L-selectin/CD62L (expressed by most leukocytes), E-selectin/CD62E (expressed by cytokine-activated endothelial cells), and P-selectin/CD62P (expressed by activated endothelial cells and platelets).

Ser/Thr-linked oligosaccharide

See O-glycan.

Sialic acids

Family of acidic sugars with a nine-carbon backbone, of which the most common is N-acetylneuraminic acid, in vertebrates.

Sialidase

Enzyme that releases sialic acid residues from a glycoconjugate. Its older name was neuraminidase, which is now used only to refer to the influenza sialidase.

Sialome

Total array of sialic acid types and linkages expressed by a particular cell tissue or organism, under specified conditions of time, space, and environment.

Siglecs

Sialic acid–binding proteins that are members of the I-type lectin family and have an amino-terminal V-set domain with typical conserved residues.

S layer

See See Surface layer.

Sphingolipids

Lipids with ceramide as their core structure.

Sphingosine

Long-chain amino alcohol (forms ceramide when in amide linkage with a fatty acid).

Sugar

A generic term often used to refer to any carbohydrate, but most frequently to low molecular weight carbohydrates that are sweet in taste. Table sugar, sucrose, is a nonreducing disaccharide (Fruβ2-1αGlc). Oligosaccharides are sometimes called “sugar chains” and individual monosaccharides in a sugar chain are sometimes referred to as “sugar residues.”

Surface layer

A protein monolayer coating often containing covalently linked glycans and found in the cell envelope of many bacteria and Archaea.

Teichoic acid

A complex polymer consisting of either phosphoglycerol- or phosphoribitol-modified carbohydrates or amino acids, found on the surface of Gram-positive bacteria.

Thrombospondin repeats

Small protein motifs (50–60 amino acids) with six conserved cysteine residues that form three disulfide bonds. They serve as sites for glycan modification.

Transcriptome

The total collection of RNA transcripts in a cell, tissue, or organism, under specific conditions of time, space, and environment.

TSRs

See Thrombospondin repeats.

Undecaprenol

A polyisoprenoid lipid carrier for glycan synthesis in bacteria.

Copyright © 2009, The Consortium of Glycobiology Editors, La Jolla, California.
Bookshelf ID: NBK1932
PubReader format: click here to try

Views

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...