TABLE 26.2

A general classification of lectins and lectin-like proteins

Category I—Defined lectin families with structural and/or evolutionary sequence similaritiesa
 β-prism lectins—Jacalin-related (B-type?)
 C-type lectins (e.g., calcium-dependent lectins such as selectins, collectins, etc.)
 eel fucolectins (E-type?)
 ficolins—fibrinogen/collagen-domain-containing lectins (F-type?)
 garlic and snowdrop lectins and related proteins (G-type?)
 galectins (formerly S-type lectins)
 hyaluronan-binding proteins or hyaladherins (H-type?)
 I-type lectins—immunoglobulin superfamily members, including the Siglec family
 amoeba lectins—Jacob and related chitin-binding proteins (J-type?)
 L-type lectins, plant legume seed lectins, ERGIC-53 in ER-Golgi pathway, calnexin family
 M-type lectins—α-mannosidase-related lectins (e.g., EDEM)
 N-type lectin nucleotide phosphohydrolases (LNPs) with glycan-binding and apyrase domains
 P-type (i.e., mannose-6-phosphate receptors)
 R-type (e.g., ricin, other plant lectins, GalNAc-SO4 receptors)
 tachylectins from horseshoe crab Tachypleus tridentatus (T-type?)
 haevin-domain lectins (e.g., wheat germ agglutinin, haevin, etc.) (W-type?)
 Xenopus egg lectins/eglectins (X-type?)
Category II—Lectin-like proteins without established evolutionary classification
 some annexins
 pentraxins with pentavalent domain structure
 some laminin G domains, recognizing glycans on α-dystroglycan
 CD11b/CD18 (β3-integrin, CR3) recognizes fungal glucans and exposed GlcNAc residues on glycoproteins
 complement factor H, recognizes cell-surface sialic acids as “self”
 tumor necrosis factor-α, binds to oligomannose N-glycans
 interleukins IL-1α, IL-1β, IL-4, IL-6, and IL-7 bind various glycans
 amphoterin binds carboxylated N-glycans
a

Category I includes all lectin families with generally agreed-upon names (e.g., C-type and R-type). In addition, the question marks (e.g., F-type? and X-type?) indicate suggested names for other families. Final acceptance of the latter terms will require a consensus among those scientists who study each respective family.

Category I includes all lectin families with generally agreed-upon names (e.g., C-type and R-type). In addition, the question marks (e.g., F-type? and X-type?) indicate suggested names for other families. Final acceptance of the latter terms will require a consensus among those scientists who study each respective family.

From: Chapter 26, Discovery and Classification of Glycan-Binding Proteins

Cover of Essentials of Glycobiology
Essentials of Glycobiology. 2nd edition.
Varki A, Cummings RD, Esko JD, et al., editors.
Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 2009.
Copyright © 2009, The Consortium of Glycobiology Editors, La Jolla, California.

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